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Nanocarriers for vascular delivery of antioxidants

Antioxidant enzymes (AOEs) catalase and superoxide dismutase (SOD) detoxify harmful reactive oxygen species, but the therapeutic utility of AOEs is hindered by inadequate delivery. AOE modification by poly-ethylene glycol (PEG) and encapsulation in PEG-coated liposomes increases the AOE bioavailabil... Full description

Journal Title: Nanomedicine Sep 2011, pp.1257-72
Main Author: Hood, Elizabeth
Other Authors: Simone, Eric , Wattamwar, Paritosh , Dziubla, Thomas , Muzykantov, Vladimir
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1743-5889 ; E-ISSN: 1748-6963 ; DOI: 10.2217/nnm.11.92
Link: http://search.proquest.com/docview/893248967/?pq-origsite=primo
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recordid: proquest893248967
title: Nanocarriers for vascular delivery of antioxidants
format: Article
creator:
  • Hood, Elizabeth
  • Simone, Eric
  • Wattamwar, Paritosh
  • Dziubla, Thomas
  • Muzykantov, Vladimir
subjects:
  • Animals–Administration & Dosage
  • Antioxidants–Administration & Dosage
  • Catalase–Methods
  • Drug Delivery Systems–Metabolism
  • Endothelium, Vascular–Chemistry
  • Humans–Administration & Dosage
  • Nanostructures–Administration & Dosage
  • Superoxide Dismutase–Administration & Dosage
  • Antioxidants
  • Catalase
  • Superoxide Dismutase
ispartof: Nanomedicine, Sep 2011, pp.1257-72
description: Antioxidant enzymes (AOEs) catalase and superoxide dismutase (SOD) detoxify harmful reactive oxygen species, but the therapeutic utility of AOEs is hindered by inadequate delivery. AOE modification by poly-ethylene glycol (PEG) and encapsulation in PEG-coated liposomes increases the AOE bioavailability...
language: eng
source:
identifier: ISSN: 1743-5889 ; E-ISSN: 1748-6963 ; DOI: 10.2217/nnm.11.92
fulltext: fulltext
issn:
  • 17435889
  • 1743-5889
  • 17486963
  • 1748-6963
url: Link


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abstractAntioxidant enzymes (AOEs) catalase and superoxide dismutase (SOD) detoxify harmful reactive oxygen species, but the therapeutic utility of AOEs is hindered by inadequate delivery. AOE modification by poly-ethylene glycol (PEG) and encapsulation in PEG-coated liposomes increases the AOE bioavailability...
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pubFuture Medicine Ltd
doi10.2217/nnm.11.92
urlhttp://search.proquest.com/docview/893248967/
issue7
volume6
date2011-09-01