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A semi-invariant V[alpha]10+ T cell antigen receptor defines a population of natural killer T cells with distinct glycolipid antigen-recognition properties

Type I natural killer T cells (NKT cells) are characterized by an invariant variable region 14-joining region 18 (V(α)14-J(α)18) T cell antigen receptor (TCR) α-chain and recognition of the glycolipid α-galactosylceramide (α-GalCer) restricted to the antigen-presenting molecule CD1d. Here we describ... Full description

Journal Title: Nature Immunology Jul 2011, Vol.12(7), pp.616-23
Main Author: Uldrich, Adam
Other Authors: Patel, Onisha , Cameron, Garth , Pellicci, Daniel , Day, E , Sullivan, Lucy , Kyparissoudis, Konstantinos , Kjer-Nielsen, Lars , Vivian, Julian , Cao, Benjamin , Brooks, Andrew , Williams, Spencer , Illarionov, Petr , Besra, Gurdyal , Turner, Stephen , Porcelli, Steven , Mccluskey, James , Smyth, Mark , Rossjohn, Jamie , Godfrey
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 15292908 ; E-ISSN: 15292916 ; DOI: 10.1038/ni.2051
Link: http://search.proquest.com/docview/896067611/?pq-origsite=primo
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title: A semi-invariant V[alpha]10+ T cell antigen receptor defines a population of natural killer T cells with distinct glycolipid antigen-recognition properties
format: Article
creator:
  • Uldrich, Adam
  • Patel, Onisha
  • Cameron, Garth
  • Pellicci, Daniel
  • Day, E
  • Sullivan, Lucy
  • Kyparissoudis, Konstantinos
  • Kjer-Nielsen, Lars
  • Vivian, Julian
  • Cao, Benjamin
  • Brooks, Andrew
  • Williams, Spencer
  • Illarionov, Petr
  • Besra, Gurdyal
  • Turner, Stephen
  • Porcelli, Steven
  • Mccluskey, James
  • Smyth, Mark
  • Rossjohn, Jamie
  • Godfrey
subjects:
  • Adjuvants, Immunologic–Pharmacology
  • Amino Acid Sequence–Immunology
  • Animals–Immunology
  • Antigens, Bacterial–Immunology
  • Antigens, Cd1d–Pharmacology
  • Cell Line–Immunology
  • Galactosylceramides–Immunology
  • Galactosylceramides–Genetics
  • Glucuronates–Immunology
  • Humans–Immunology
  • Mice–Immunology
  • Mice, Mutant Strains–Immunology
  • Molecular Sequence Data–Immunology
  • Natural Killer T-Cells–Immunology
  • Receptors, Antigen, T-Cell, Alpha-Beta–Immunology
  • Receptors, Antigen, T-Cell, Alpha-Beta–Immunology
  • Adjuvants, Immunologic
  • Antigens, Bacterial
  • Antigens, Cd1d
  • Galactosylceramides
ispartof: Nature Immunology, Jul 2011, Vol.12(7), pp.616-23
description: Type I natural killer T cells (NKT cells) are characterized by an invariant variable region 14-joining region 18 (V(α)14-J(α)18) T cell antigen receptor (TCR) α-chain and recognition of the glycolipid α-galactosylceramide (α-GalCer) restricted to the antigen-presenting molecule CD1d. Here we describe a population of α-GalCer-reactive NKT cells that expressed a canonical V(α)10-J(α)50 TCR α-chain, which showed a preference for α-glucosylceramide (α-GlcCer) and bacterial α-glucuronic acid-containing glycolipid antigens. Structurally, despite very limited TCRα sequence identity, the V(α)10 TCR-CD1d-α-GlcCer complex had a docking mode similar to that of type I TCR-CD1d-α-GalCer complexes, although differences at the antigen-binding interface accounted for the altered antigen specificity. Our findings provide new insight into the structural basis and evolution of glycolipid antigen recognition and have notable implications for the scope and immunological role of glycolipid-specific T cell responses.
language: eng
source:
identifier: ISSN: 15292908 ; E-ISSN: 15292916 ; DOI: 10.1038/ni.2051
fulltext: fulltext
issn:
  • 15292908
  • 1529-2908
  • 15292916
  • 1529-2916
url: Link


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titleA semi-invariant V[alpha]10+ T cell antigen receptor defines a population of natural killer T cells with distinct glycolipid antigen-recognition properties
creatorUldrich, Adam ; Patel, Onisha ; Cameron, Garth ; Pellicci, Daniel ; Day, E ; Sullivan, Lucy ; Kyparissoudis, Konstantinos ; Kjer-Nielsen, Lars ; Vivian, Julian ; Cao, Benjamin ; Brooks, Andrew ; Williams, Spencer ; Illarionov, Petr ; Besra, Gurdyal ; Turner, Stephen ; Porcelli, Steven ; Mccluskey, James ; Smyth, Mark ; Rossjohn, Jamie ; Godfrey
ispartofNature Immunology, Jul 2011, Vol.12(7), pp.616-23
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subjectAdjuvants, Immunologic–Pharmacology ; Amino Acid Sequence–Immunology ; Animals–Immunology ; Antigens, Bacterial–Immunology ; Antigens, Cd1d–Pharmacology ; Cell Line–Immunology ; Galactosylceramides–Immunology ; Galactosylceramides–Genetics ; Glucuronates–Immunology ; Humans–Immunology ; Mice–Immunology ; Mice, Mutant Strains–Immunology ; Molecular Sequence Data–Immunology ; Natural Killer T-Cells–Immunology ; Receptors, Antigen, T-Cell, Alpha-Beta–Immunology ; Receptors, Antigen, T-Cell, Alpha-Beta–Immunology ; Adjuvants, Immunologic ; Antigens, Bacterial ; Antigens, Cd1d ; Galactosylceramides
descriptionType I natural killer T cells (NKT cells) are characterized by an invariant variable region 14-joining region 18 (V(α)14-J(α)18) T cell antigen receptor (TCR) α-chain and recognition of the glycolipid α-galactosylceramide (α-GalCer) restricted to the antigen-presenting molecule CD1d. Here we describe a population of α-GalCer-reactive NKT cells that expressed a canonical V(α)10-J(α)50 TCR α-chain, which showed a preference for α-glucosylceramide (α-GlcCer) and bacterial α-glucuronic acid-containing glycolipid antigens. Structurally, despite very limited TCRα sequence identity, the V(α)10 TCR-CD1d-α-GlcCer complex had a docking mode similar to that of type I TCR-CD1d-α-GalCer complexes, although differences at the antigen-binding interface accounted for the altered antigen specificity. Our findings provide new insight into the structural basis and evolution of glycolipid antigen recognition and have notable implications for the scope and immunological role of glycolipid-specific T cell responses.
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titleA semi-invariant V[alpha]10+ T cell antigen receptor defines a population of natural killer T cells with distinct glycolipid antigen-recognition properties
descriptionType I natural killer T cells (NKT cells) are characterized by an invariant variable region 14-joining region 18 (V(α)14-J(α)18) T cell antigen receptor (TCR) α-chain and recognition of the glycolipid α-galactosylceramide (α-GalCer) restricted to the antigen-presenting molecule CD1d. Here we describe a population of α-GalCer-reactive NKT cells that expressed a canonical V(α)10-J(α)50 TCR α-chain, which showed a preference for α-glucosylceramide (α-GlcCer) and bacterial α-glucuronic acid-containing glycolipid antigens. Structurally, despite very limited TCRα sequence identity, the V(α)10 TCR-CD1d-α-GlcCer complex had a docking mode similar to that of type I TCR-CD1d-α-GalCer complexes, although differences at the antigen-binding interface accounted for the altered antigen specificity. Our findings provide new insight into the structural basis and evolution of glycolipid antigen recognition and have notable implications for the scope and immunological role of glycolipid-specific T cell responses.
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titleA semi-invariant V[alpha]10+ T cell antigen receptor defines a population of natural killer T cells with distinct glycolipid antigen-recognition properties
authorUldrich, Adam ; Patel, Onisha ; Cameron, Garth ; Pellicci, Daniel ; Day, E ; Sullivan, Lucy ; Kyparissoudis, Konstantinos ; Kjer-Nielsen, Lars ; Vivian, Julian ; Cao, Benjamin ; Brooks, Andrew ; Williams, Spencer ; Illarionov, Petr ; Besra, Gurdyal ; Turner, Stephen ; Porcelli, Steven ; Mccluskey, James ; Smyth, Mark ; Rossjohn, Jamie ; Godfrey
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1Amino Acid Sequence–Immunology
2Animals–Immunology
3Antigens, Bacterial–Immunology
4Antigens, Cd1d–Pharmacology
5Cell Line–Immunology
6Galactosylceramides–Immunology
7Galactosylceramides–Genetics
8Glucuronates–Immunology
9Humans–Immunology
10Mice–Immunology
11Mice, Mutant Strains–Immunology
12Molecular Sequence Data–Immunology
13Natural Killer T-Cells–Immunology
14Receptors, Antigen, T-Cell, Alpha-Beta–Immunology
15Adjuvants, Immunologic
16Antigens, Bacterial
17Antigens, Cd1d
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atitleA semi-invariant V[alpha]10+ T cell antigen receptor defines a population of natural killer T cells with distinct glycolipid antigen-recognition properties
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abstractType I natural killer T cells (NKT cells) are characterized by an invariant variable region 14-joining region 18 (V(α)14-J(α)18) T cell antigen receptor (TCR) α-chain and recognition of the glycolipid α-galactosylceramide (α-GalCer) restricted to the antigen-presenting molecule CD1d. Here we describe a population of α-GalCer-reactive NKT cells that expressed a canonical V(α)10-J(α)50 TCR α-chain, which showed a preference for α-glucosylceramide (α-GlcCer) and bacterial α-glucuronic acid-containing glycolipid antigens. Structurally, despite very limited TCRα sequence identity, the V(α)10 TCR-CD1d-α-GlcCer complex had a docking mode similar to that of type I TCR-CD1d-α-GalCer complexes, although differences at the antigen-binding interface accounted for the altered antigen specificity. Our findings provide new insight into the structural basis and evolution of glycolipid antigen recognition and have notable implications for the scope and immunological role of glycolipid-specific T cell responses.
copNew York
pubNature Publishing Group
doi10.1038/ni.2051
urlhttp://search.proquest.com/docview/896067611/
date2011-07-01