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Linking long-term dietary patterns with gut microbial enterotypes.

Different members of the human gut microbiota have distinct and characteristic influences on health and disease. Wu et al. (p. 105, published online 1 September; see the Perspective by Gophna) attempted to characterize the dietary and environmental variables that affect the microbiota in a pair of s... Full description

Journal Title: Science (New York N.Y.), October 7, 2011, Vol.334(6052), pp.105-108
Main Author: Wu, Gary D
Other Authors: Chen, Jun , Hoffmann, Christian , Bittinger, Kyle , Chen, Ying-Yu , Keilbaugh, Sue A , Bewtra, Meenakshi , Knights, Dan , Walters, William A , Knight, Rob , Sinha, Rohini , Gilroy, Erin , Gupta, Kernika , Baldassano, Robert , Nessel, Lisa , Li, Hongzhe , Bushman, Frederic D , Lewis, James D
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1095-9203 ; DOI: 1095-9203 ; DOI: 10.1126/science.1208344
Link: http://search.proquest.com/docview/896833882/?pq-origsite=primo
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title: Linking long-term dietary patterns with gut microbial enterotypes.
format: Article
creator:
  • Wu, Gary D
  • Chen, Jun
  • Hoffmann, Christian
  • Bittinger, Kyle
  • Chen, Ying-Yu
  • Keilbaugh, Sue A
  • Bewtra, Meenakshi
  • Knights, Dan
  • Walters, William A
  • Knight, Rob
  • Sinha, Rohini
  • Gilroy, Erin
  • Gupta, Kernika
  • Baldassano, Robert
  • Nessel, Lisa
  • Li, Hongzhe
  • Bushman, Frederic D
  • Lewis, James D
subjects:
  • Adolescent–Classification
  • Adult–Isolation & Purification
  • Bacteria–Classification
  • Bacteroides–Isolation & Purification
  • Child–Administration & Dosage
  • Child, Preschool–Administration & Dosage
  • Cross-Sectional Studies–Administration & Dosage
  • Diet–Microbiology
  • Dietary Carbohydrates–Microbiology
  • Dietary Fats–Classification
  • Dietary Fiber–Isolation & Purification
  • Feces–Classification
  • Gastrointestinal Tract–Isolation & Purification
  • Humans–Isolation & Purification
  • Metagenome–Isolation & Purification
  • Middle Aged–Isolation & Purification
  • Prevotella–Isolation & Purification
  • Ruminococcus–Isolation & Purification
  • Time Factors–Isolation & Purification
  • Young Adult–Isolation & Purification
  • Dietary Carbohydrates
  • Dietary Fats
  • Dietary Fiber
ispartof: Science (New York, N.Y.), October 7, 2011, Vol.334(6052), pp.105-108
description: Different members of the human gut microbiota have distinct and characteristic influences on health and disease. Wu et al. (p. 105, published online 1 September; see the Perspective by Gophna) attempted to characterize the dietary and environmental variables that affect the microbiota in a pair of studies on humans. In one study, stool samples were taken for microbial sequencing from 99 volunteers whose long-term dietary preferences were known and defined. In another study, 10 people were segregated and put on controlled diets, and their stools were sampled at 1 and 10 days after recruitment. In the long-term study, three distinct microbiomes were apparent, which had characteristic signature organisms: A Bacteroides-dominated community was associated with people who ate animal protein and saturated fats, Ruminococcus tended to be linked with alcohol intake and polyunsaturated fat consumption, and--finally--Prevotella was found in people who enjoyed a carbohydrate-based diet. Although dietary perturbation in the short-term study caused a transient change in the respective enterotype, there were no marked shifts from one enterotype to another. Diet strongly affects human health, partly by modulating gut microbiome composition. We used diet inventories and 16S rDNA sequencing to characterize fecal samples from 98 individuals. Fecal communities clustered into enterotypes distinguished primarily by levels of Bacteroides and Prevotella. Enterotypes were strongly associated with long-term diets, particularly protein and animal fat (Bacteroides) versus carbohydrates (Prevotella). A controlled-feeding study of 10 subjects showed that microbiome composition changed detectably within 24 hours of initiating a high-fat/low-fiber or low-fat/high-fiber diet, but that enterotype identity remained stable during the 10-day study. Thus, alternative enterotype states are associated with long-term diet. [PUBLICATION ]
language: eng
source:
identifier: E-ISSN: 1095-9203 ; DOI: 1095-9203 ; DOI: 10.1126/science.1208344
fulltext: fulltext
issn:
  • 10959203
  • 1095-9203
url: Link


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descriptionDifferent members of the human gut microbiota have distinct and characteristic influences on health and disease. Wu et al. (p. 105, published online 1 September; see the Perspective by Gophna) attempted to characterize the dietary and environmental variables that affect the microbiota in a pair of studies on humans. In one study, stool samples were taken for microbial sequencing from 99 volunteers whose long-term dietary preferences were known and defined. In another study, 10 people were segregated and put on controlled diets, and their stools were sampled at 1 and 10 days after recruitment. In the long-term study, three distinct microbiomes were apparent, which had characteristic signature organisms: A Bacteroides-dominated community was associated with people who ate animal protein and saturated fats, Ruminococcus tended to be linked with alcohol intake and polyunsaturated fat consumption, and--finally--Prevotella was found in people who enjoyed a carbohydrate-based diet. Although dietary perturbation in the short-term study caused a transient change in the respective enterotype, there were no marked shifts from one enterotype to another. Diet strongly affects human health, partly by modulating gut microbiome composition. We used diet inventories and 16S rDNA sequencing to characterize fecal samples from 98 individuals. Fecal communities clustered into enterotypes distinguished primarily by levels of Bacteroides and Prevotella. Enterotypes were strongly associated with long-term diets, particularly protein and animal fat (Bacteroides) versus carbohydrates (Prevotella). A controlled-feeding study of 10 subjects showed that microbiome composition changed detectably within 24 hours of initiating a high-fat/low-fiber or low-fat/high-fiber diet, but that enterotype identity remained stable during the 10-day study. Thus, alternative enterotype states are associated with long-term diet. [PUBLICATION ]
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titleLinking long-term dietary patterns with gut microbial enterotypes.
authorWu, Gary D ; Chen, Jun ; Hoffmann, Christian ; Bittinger, Kyle ; Chen, Ying-Yu ; Keilbaugh, Sue A ; Bewtra, Meenakshi ; Knights, Dan ; Walters, William A ; Knight, Rob ; Sinha, Rohini ; Gilroy, Erin ; Gupta, Kernika ; Baldassano, Robert ; Nessel, Lisa ; Li, Hongzhe ; Bushman, Frederic D ; Lewis, James D
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