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A marked synergistic effect in antitumor activity of salan titanium(IV) complexes bearing two differently substituted aromatic rings.

Salan titanium(IV) complexes of differently substituted aromatic rings, where one ring is para-nitrated and another is ortho,para-halogenated, demonstrate exceptionally high anticancer activity, with IC(50) values of

Journal Title: Journal of the American Chemical Society October 26, 2011, Vol.133(42), pp.16812-16814
Main Author: Glasner, Hagai
Other Authors: Tshuva, Edit Y
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1520-5126 ; DOI: 1520-5126 ; DOI: 10.1021/ja208219f
Link: http://search.proquest.com/docview/900625077/?pq-origsite=primo
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recordid: proquest900625077
title: A marked synergistic effect in antitumor activity of salan titanium(IV) complexes bearing two differently substituted aromatic rings.
format: Article
creator:
  • Glasner, Hagai
  • Tshuva, Edit Y
subjects:
  • Antineoplastic Agents–Chemical Synthesis
  • Cell Survival–Chemistry
  • Ht29 Cells–Pharmacology
  • Humans–Drug Effects
  • Inhibitory Concentration 50–Chemical Synthesis
  • Molecular Structure–Chemistry
  • Organometallic Compounds–Pharmacology
  • Titanium–Chemistry
  • Antineoplastic Agents
  • Organometallic Compounds
  • Titanium
ispartof: Journal of the American Chemical Society, October 26, 2011, Vol.133(42), pp.16812-16814
description: Salan titanium(IV) complexes of differently substituted aromatic rings, where one ring is para-nitrated and another is ortho,para-halogenated, demonstrate exceptionally high anticancer activity, with IC(50) values of
language: eng
source:
identifier: E-ISSN: 1520-5126 ; DOI: 1520-5126 ; DOI: 10.1021/ja208219f
fulltext: no_fulltext
issn:
  • 15205126
  • 1520-5126
url: Link


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titleA marked synergistic effect in antitumor activity of salan titanium(IV) complexes bearing two differently substituted aromatic rings.
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descriptionSalan titanium(IV) complexes of differently substituted aromatic rings, where one ring is para-nitrated and another is ortho,para-halogenated, demonstrate exceptionally high anticancer activity, with IC(50) values of <1 μM, exceeding that of cisplatin by ~30-fold. Whereas an additive effect in hydrolytic stability was detected for these highly stable complexes, an unexpected synergistic effect in anticancer activity makes these hybrid complexes substantially more active than both their symmetrical analogues alone and their equimolar mixture.
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