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Origin, phenotype and function of human natural killer cells in pregnancy.

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.it.2011.06.013 Byline: Paola Vacca (1), Lorenzo Moretta (2), Alessandro Moretta (3), Maria Cristina Mingari (1)(3) Abstract: During the early phases of pregnancy, natural killer (NK) cells are the predominant... Full description

Journal Title: Trends in immunology November 2011, Vol.32(11), pp.517-523
Main Author: Vacca, Paola
Other Authors: Moretta, Lorenzo , Moretta, Alessandro , Mingari, Maria Cristina
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1471-4981 ; DOI: 10.1016/j.it.2011.06.013
Link: http://search.proquest.com/docview/900640732/?pq-origsite=primo
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title: Origin, phenotype and function of human natural killer cells in pregnancy.
format: Article
creator:
  • Vacca, Paola
  • Moretta, Lorenzo
  • Moretta, Alessandro
  • Mingari, Maria Cristina
subjects:
  • Antigens, Cd34–Immunology
  • Female–Immunology
  • Humans–Immunology
  • Killer Cells, Natural–Immunology
  • Lipopolysaccharide Receptors–Immunology
  • Phenotype–Immunology
  • Pregnancy–Immunology
  • T-Lymphocytes, Regulatory–Immunology
  • Antigens, Cd34
  • Lipopolysaccharide Receptors
ispartof: Trends in immunology, November 2011, Vol.32(11), pp.517-523
description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.it.2011.06.013 Byline: Paola Vacca (1), Lorenzo Moretta (2), Alessandro Moretta (3), Maria Cristina Mingari (1)(3) Abstract: During the early phases of pregnancy, natural killer (NK) cells are the predominant lymphoid cells in the human decidua. Here, rather than act as killers and/or drivers of inflammation, NK cells contribute to tissue building and remodeling and formation of new vessels due to the release of interleukin-8, vascular endothelial growth factor, stromal cell-derived factor-1 and interferon gamma-inducible protein-10. Here, we propose that the interaction of NK cells with CD14.sup.+ myelomonocytic cells to promote induction of T regulatory cells plays a pivotal role in immunosuppression and tolerance towards the fetus allograft. Importantly, CD34.sup.+ hematopoietic precursors are present in human decidua and may give rise to decidual NK cells. Defects in decidual NK cell generation, or in appropriate functional interactions with other cell types, could have major consequences for successful pregnancy. Author Affiliation: (1) National Institute for Cancer Research, Largo R. Benzi, 16132 Genova, Italy (2) Giannina Gaslini Institute, Largo G. Gaslini, 16147 Genova, Italy (3) Department of Experimental Medicine and Center of Excellence for Biomedical Research, University of Genova, Genova, Italy
language: eng
source:
identifier: E-ISSN: 1471-4981 ; DOI: 10.1016/j.it.2011.06.013
fulltext: fulltext
issn:
  • 14714981
  • 1471-4981
url: Link


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titleOrigin, phenotype and function of human natural killer cells in pregnancy.
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subjectAntigens, Cd34–Immunology ; Female–Immunology ; Humans–Immunology ; Killer Cells, Natural–Immunology ; Lipopolysaccharide Receptors–Immunology ; Phenotype–Immunology ; Pregnancy–Immunology ; T-Lymphocytes, Regulatory–Immunology ; Antigens, Cd34 ; Lipopolysaccharide Receptors
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