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Intermolecular masking of the HIV-1 Rev NLS by the cellular protein HIC: Novel insights into the regulation of Rev nuclear import

Abstract Background: The HIV-1 regulatory protein Rev, which is essential for viral replication, mediates the nuclear export of unspliced viral transcripts. Rev nuclear function requires active nucleocytoplasmic shuttling, and Rev nuclear import is mediated by the recognition of its Nuclear Localisa... Full description

Journal Title: Retrovirology 2011, Vol.8, p.17
Main Author: Gu, Lili
Other Authors: Tsuji, Takahiro , Jarboui, Mohamed , Yeo, Geok , Sheehy, Noreen , Hall, William , Gautier, Virginie
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 17424690 ; DOI: 10.1186/1742-4690-8-17
Zum Text:
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recordid: proquest902290120
title: Intermolecular masking of the HIV-1 Rev NLS by the cellular protein HIC: Novel insights into the regulation of Rev nuclear import
format: Article
creator:
  • Gu, Lili
  • Tsuji, Takahiro
  • Jarboui, Mohamed
  • Yeo, Geok
  • Sheehy, Noreen
  • Hall, William
  • Gautier, Virginie
subjects:
  • Active Transport, Cell Nucleus–Metabolism
  • Animals–Genetics
  • Cos Cells–Metabolism
  • Cell Line–Metabolism
  • Cell Nucleus–Genetics
  • Cercopithecus Aethiops–Metabolism
  • Gene Expression Regulation, Viral–Genetics
  • HIV-1–Metabolism
  • HIV-1–Genetics
  • Hela Cells–Metabolism
  • Humans–Genetics
  • Jurkat Cells–Metabolism
  • Karyopherins–Metabolism
  • Myogenic Regulatory Factors–Metabolism
  • Myogenic Regulatory Factors–Metabolism
  • Nuclear Localization Signals–Metabolism
  • Nuclear Localization Signals–Metabolism
  • Protein Binding–Metabolism
  • U937 Cells–Metabolism
  • Beta Karyopherins
ispartof: Retrovirology, 2011, Vol.8, p.17
description: Abstract Background: The HIV-1 regulatory protein Rev, which is essential for viral replication, mediates the nuclear export of unspliced viral transcripts. Rev nuclear function requires active nucleocytoplasmic shuttling, and Rev nuclear import is mediated by the recognition of its Nuclear Localisation...
language: eng
source:
identifier: E-ISSN: 17424690 ; DOI: 10.1186/1742-4690-8-17
fulltext: fulltext_linktorsrc
issn:
  • 17424690
  • 1742-4690
url: Link


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titleIntermolecular masking of the HIV-1 Rev NLS by the cellular protein HIC: Novel insights into the regulation of Rev nuclear import
creatorGu, Lili ; Tsuji, Takahiro ; Jarboui, Mohamed ; Yeo, Geok ; Sheehy, Noreen ; Hall, William ; Gautier, Virginie
ispartofRetrovirology, 2011, Vol.8, p.17
identifierE-ISSN: 17424690 ; DOI: 10.1186/1742-4690-8-17
subjectActive Transport, Cell Nucleus–Metabolism ; Animals–Genetics ; Cos Cells–Metabolism ; Cell Line–Metabolism ; Cell Nucleus–Genetics ; Cercopithecus Aethiops–Metabolism ; Gene Expression Regulation, Viral–Genetics ; HIV-1–Metabolism ; HIV-1–Genetics ; Hela Cells–Metabolism ; Humans–Genetics ; Jurkat Cells–Metabolism ; Karyopherins–Metabolism ; Myogenic Regulatory Factors–Metabolism ; Myogenic Regulatory Factors–Metabolism ; Nuclear Localization Signals–Metabolism ; Nuclear Localization Signals–Metabolism ; Protein Binding–Metabolism ; U937 Cells–Metabolism ; Beta Karyopherins
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titleIntermolecular masking of the HIV-1 Rev NLS by the cellular protein HIC: Novel insights into the regulation of Rev nuclear import
authorGu, Lili ; Tsuji, Takahiro ; Jarboui, Mohamed ; Yeo, Geok ; Sheehy, Noreen ; Hall, William ; Gautier, Virginie
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abstractAbstract Background: The HIV-1 regulatory protein Rev, which is essential for viral replication, mediates the nuclear export of unspliced viral transcripts. Rev nuclear function requires active nucleocytoplasmic shuttling, and Rev nuclear import is mediated by the recognition of its Nuclear Localisation...
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