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Triggered cargo release by encapsulated enzymatic catalysis in capsosomes.

We report the coencapsulation of glutathione reductase and disulfide-linked polymer-oligopeptide conjugates into capsosomes, polymer carrier capsules containing liposomal subcompartments. The architecture of the capsosomes enables a temperature-triggered conversion of oxidized glutathione to its red... Full description

Journal Title: Nano letters November 9, 2011, Vol.11(11), pp.4958-4963
Main Author: Chandrawati, Rona
Other Authors: Odermatt, Pascal D , Chong, Siow-Feng , Price, Andrew D , Städler, Brigitte , Caruso, Frank
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1530-6992 ; DOI: 1530-6992 ; DOI: 10.1021/nl202906j
Link: http://search.proquest.com/docview/903144187/?pq-origsite=primo
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recordid: proquest903144187
title: Triggered cargo release by encapsulated enzymatic catalysis in capsosomes.
format: Article
creator:
  • Chandrawati, Rona
  • Odermatt, Pascal D
  • Chong, Siow-Feng
  • Price, Andrew D
  • Städler, Brigitte
  • Caruso, Frank
subjects:
  • Catalysis–Chemistry
  • Delayed-Action Preparations–Chemistry
  • Diffusion–Chemistry
  • Glutathione Reductase–Chemistry
  • Liposomes–Chemistry
  • Nanocapsules–Chemistry
  • Temperature–Chemistry
  • Delayed-Action Preparations
  • Liposomes
  • Nanocapsules
  • Glutathione Reductase
ispartof: Nano letters, November 9, 2011, Vol.11(11), pp.4958-4963
description: We report the coencapsulation of glutathione reductase and disulfide-linked polymer-oligopeptide conjugates into capsosomes, polymer carrier capsules containing liposomal subcompartments. The architecture of the capsosomes enables a temperature-triggered conversion of oxidized glutathione to its reduced sulfhydryl form by the encapsulated glutathione reductase. The reduced glutathione subsequently induces the release of the encapsulated oligopeptides from the capsosomes by reducing the disulfide linkages of the conjugates. This study highlights the potential of capsosomes to continuously generate a potent antioxidant while simultaneously releasing small molecule therapeutics.
language: eng
source:
identifier: E-ISSN: 1530-6992 ; DOI: 1530-6992 ; DOI: 10.1021/nl202906j
fulltext: no_fulltext
issn:
  • 15306992
  • 1530-6992
url: Link


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titleTriggered cargo release by encapsulated enzymatic catalysis in capsosomes.
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subjectCatalysis–Chemistry ; Delayed-Action Preparations–Chemistry ; Diffusion–Chemistry ; Glutathione Reductase–Chemistry ; Liposomes–Chemistry ; Nanocapsules–Chemistry ; Temperature–Chemistry ; Delayed-Action Preparations ; Liposomes ; Nanocapsules ; Glutathione Reductase
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descriptionWe report the coencapsulation of glutathione reductase and disulfide-linked polymer-oligopeptide conjugates into capsosomes, polymer carrier capsules containing liposomal subcompartments. The architecture of the capsosomes enables a temperature-triggered conversion of oxidized glutathione to its reduced sulfhydryl form by the encapsulated glutathione reductase. The reduced glutathione subsequently induces the release of the encapsulated oligopeptides from the capsosomes by reducing the disulfide linkages of the conjugates. This study highlights the potential of capsosomes to continuously generate a potent antioxidant while simultaneously releasing small molecule therapeutics.
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