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Reduced thymic output is a major mechanism of immune reconstitution failure in HIV-infected patients after long-term antiretroviral therapy.

BACKGROUNDApproximately 20% of human immunodeficiency virus type 1 (HIV-1)--infected adults do not normalize their CD4(+) T lymphocytes after long-term effective highly active antiretroviral therapy (HAART). The mechanistic basis for this failure is unclear. METHODSSeventy-four patients were followe... Full description

Journal Title: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America November 2011, Vol.53(9), pp.944-951
Main Author: Li, Taisheng
Other Authors: Wu, Ning , Dai, Yi , Qiu, Zhifeng , Han, Yang , Xie, Jing , Zhu, Ting , Li, Yanling
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1537-6591 ; DOI: 10.1093/cid/cir552
Link: http://search.proquest.com/docview/903661122/?pq-origsite=primo
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title: Reduced thymic output is a major mechanism of immune reconstitution failure in HIV-infected patients after long-term antiretroviral therapy.
format: Article
creator:
  • Li, Taisheng
  • Wu, Ning
  • Dai, Yi
  • Qiu, Zhifeng
  • Han, Yang
  • Xie, Jing
  • Zhu, Ting
  • Li, Yanling
subjects:
  • Adult–Administration & Dosage
  • Anti-HIV Agents–Immunology
  • Antiretroviral Therapy, Highly Active–Drug Therapy
  • Cd4 Lymphocyte Count–Immunology
  • Cd4-Positive T-Lymphocytes–Virology
  • Female–Isolation & Purification
  • Follow-Up Studies–Immunology
  • HIV Infections–Pathology
  • HIV-1–Pathology
  • Humans–Pathology
  • Male–Pathology
  • Middle Aged–Pathology
  • Thymus Gland–Pathology
  • Treatment Failure–Pathology
  • Anti-HIV Agents
ispartof: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, November 2011, Vol.53(9), pp.944-951
description: BACKGROUNDApproximately 20% of human immunodeficiency virus type 1 (HIV-1)--infected adults do not normalize their CD4(+) T lymphocytes after long-term effective highly active antiretroviral therapy (HAART). The mechanistic basis for this failure is unclear. METHODSSeventy-four patients were followed up regularly for 3-7 years. Patients with undetectable plasma viral load ( 300/μL or >30% compared with baseline. RESULTSCompared with 17 immunological responders, 13 immunological nonresponders had a lower magnitude of naive CD4(+) T-cell increase, a lower percentage of recent thymic immigrants (CD31(+)%), and a higher percentage of activated CD8(+) T cells. Furthermore, unlike CD4(+) T cells, which increased along with the decrease of viral load, the...
language: eng
source:
identifier: E-ISSN: 1537-6591 ; DOI: 10.1093/cid/cir552
fulltext: fulltext
issn:
  • 15376591
  • 1537-6591
url: Link


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titleReduced thymic output is a major mechanism of immune reconstitution failure in HIV-infected patients after long-term antiretroviral therapy.
creatorLi, Taisheng ; Wu, Ning ; Dai, Yi ; Qiu, Zhifeng ; Han, Yang ; Xie, Jing ; Zhu, Ting ; Li, Yanling
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identifierE-ISSN: 1537-6591 ; DOI: 10.1093/cid/cir552
subjectAdult–Administration & Dosage ; Anti-HIV Agents–Immunology ; Antiretroviral Therapy, Highly Active–Drug Therapy ; Cd4 Lymphocyte Count–Immunology ; Cd4-Positive T-Lymphocytes–Virology ; Female–Isolation & Purification ; Follow-Up Studies–Immunology ; HIV Infections–Pathology ; HIV-1–Pathology ; Humans–Pathology ; Male–Pathology ; Middle Aged–Pathology ; Thymus Gland–Pathology ; Treatment Failure–Pathology ; Anti-HIV Agents
descriptionBACKGROUNDApproximately 20% of human immunodeficiency virus type 1 (HIV-1)--infected adults do not normalize their CD4(+) T lymphocytes after long-term effective highly active antiretroviral therapy (HAART). The mechanistic basis for this failure is unclear. METHODSSeventy-four patients were followed up regularly for 3-7 years. Patients with undetectable plasma viral load ( 300/μL or >30% compared with baseline. RESULTSCompared with 17 immunological responders, 13 immunological nonresponders had a lower magnitude of naive CD4(+) T-cell increase, a lower percentage of recent thymic immigrants (CD31(+)%), and a higher percentage of activated CD8(+) T cells. Furthermore, unlike CD4(+) T cells, which increased along with the decrease of viral load, the...
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titleReduced thymic output is a major mechanism of immune reconstitution failure in HIV-infected patients after long-term antiretroviral therapy.
descriptionBACKGROUNDApproximately 20% of human immunodeficiency virus type 1 (HIV-1)--infected adults do not normalize their CD4(+) T lymphocytes after long-term effective highly active antiretroviral therapy (HAART). The mechanistic basis for this failure is unclear. METHODSSeventy-four patients were followed up regularly for 3-7 years. Patients with undetectable plasma viral load ( 300/μL or >30% compared with baseline. RESULTSCompared with 17 immunological responders, 13 immunological nonresponders had a lower magnitude of naive CD4(+) T-cell increase, a lower percentage of recent thymic immigrants (CD31(+)%), and a higher percentage of activated CD8(+) T cells. Furthermore, unlike CD4(+) T cells, which increased along with the decrease of viral load, the...
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abstractBACKGROUNDApproximately 20% of human immunodeficiency virus type 1 (HIV-1)--infected adults do not normalize their CD4(+) T lymphocytes after long-term effective highly active antiretroviral therapy (HAART). The mechanistic basis for this failure is unclear. METHODSSeventy-four patients were followed up regularly for 3-7 years. Patients with undetectable plasma viral load ( 300/μL or >30% compared with baseline. RESULTSCompared with 17 immunological responders, 13 immunological nonresponders had a lower magnitude of naive CD4(+) T-cell increase, a lower percentage of recent thymic immigrants (CD31(+)%), and a higher percentage of activated CD8(+) T cells. Furthermore, unlike CD4(+) T cells, which increased along with the decrease of viral load, the...
doi10.1093/cid/cir552
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issn10584838
date2011-11-01