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A Burkholderia pseudomallei toxin inhibits helicase activity of translation factor eIF4A.

Journal Title: Science (New York N.Y.), November 11, 2011, Vol.334(6057), pp.821-824
Main Author: Cruz-Migoni, Abimael
Other Authors: Hautbergue, Guillaume M , Artymiuk, Peter J , Baker, Patrick J , Bokori-Brown, Monika , Chang, Chung-Te , Dickman, Mark J , Essex-Lopresti, Angela , Harding, Sarah V , Mahadi, Nor Muhammad , Marshall, Laura E , Mobbs, George W , Mohamed, Rahmah , Nathan, Sheila , Ngugi, Sarah A , Ong, Catherine , Ooi, Wen Fong , Partridge, Lynda J , Phillips, Helen L , Raih, M Firdaus , Ruzheinikov, Sergei , Sarkar-Tyson, Mitali , Sedelnikova, Svetlana E , Smither, Sophie J , Tan, Patrick , Titball, Richard W , Wilson, Stuart A , Rice, David W
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: © ProQuest LLC All rights reserved
ID: E-ISSN: 1095-9203 ; DOI: 10.1126/science.1211915
Link: http://search.proquest.com/docview/904010758/?pq-origsite=primo
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recordid: proquest904010758
title: A Burkholderia pseudomallei toxin inhibits helicase activity of translation factor eIF4A.
format: Article
creator:
  • Cruz-Migoni, Abimael
  • Hautbergue, Guillaume M
  • Artymiuk, Peter J
  • Baker, Patrick J
  • Bokori-Brown, Monika
  • Chang, Chung-Te
  • Dickman, Mark J
  • Essex-Lopresti, Angela
  • Harding, Sarah V
  • Mahadi, Nor Muhammad
  • Marshall, Laura E
  • Mobbs, George W
  • Mohamed, Rahmah
  • Nathan, Sheila
  • Ngugi, Sarah A
  • Ong, Catherine
  • Ooi, Wen Fong
  • Partridge, Lynda J
  • Phillips, Helen L
  • Raih, M Firdaus
  • Ruzheinikov, Sergei
  • Sarkar-Tyson, Mitali
  • Sedelnikova, Svetlana E
  • Smither, Sophie J
  • Tan, Patrick
  • Titball, Richard W
  • Wilson, Stuart A
  • Rice, David W
subjects:
  • Amino Acid Motifs–Chemistry
  • Animals–Genetics
  • Bacterial Proteins–Metabolism
  • Bacterial Toxins–Toxicity
  • Burkholderia Pseudomallei–Chemistry
  • Catalytic Domain–Genetics
  • Cell Line–Metabolism
  • Crystallography, X-Ray–Toxicity
  • Cytotoxins–Chemistry
  • Escherichia Coli Proteins–Pathogenicity
  • Eukaryotic Initiation Factor-4a–Chemistry
  • Glutamine–Genetics
  • Humans–Metabolism
  • Mice–Toxicity
  • Mice, Inbred Balb C–Chemistry
  • Models, Molecular–Antagonists & Inhibitors
  • Mutant Proteins–Metabolism
  • Peptide Chain Initiation, Translational–Metabolism
  • Protein Binding–Toxicity
  • Protein Conformation–Drug Effects
  • Protein Structure, Secondary–Drug Effects
  • Protein Structure, Tertiary–Drug Effects
  • Bpsl1549 Protein, Burkholderia Pseudomallei
  • Bacterial Proteins
  • Bacterial Toxins
  • Cytotoxins
  • Escherichia Coli Proteins
  • Mutant Proteins
  • Glutamine
  • Cytotoxic Necrotizing Factor Type 1
  • Eukaryotic Initiation Factor-4a
ispartof: Science (New York, N.Y.), November 11, 2011, Vol.334(6057), pp.821-824
description:
language: eng
source: © ProQuest LLC All rights reserved
identifier: E-ISSN: 1095-9203 ; DOI: 10.1126/science.1211915
fulltext: no_fulltext
issn:
  • 10959203
  • 1095-9203
url: Link


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titleA Burkholderia pseudomallei toxin inhibits helicase activity of translation factor eIF4A.
creatorCruz-Migoni, Abimael ; Hautbergue, Guillaume M ; Artymiuk, Peter J ; Baker, Patrick J ; Bokori-Brown, Monika ; Chang, Chung-Te ; Dickman, Mark J ; Essex-Lopresti, Angela ; Harding, Sarah V ; Mahadi, Nor Muhammad ; Marshall, Laura E ; Mobbs, George W ; Mohamed, Rahmah ; Nathan, Sheila ; Ngugi, Sarah A ; Ong, Catherine ; Ooi, Wen Fong ; Partridge, Lynda J ; Phillips, Helen L ; Raih, M Firdaus ; Ruzheinikov, Sergei ; Sarkar-Tyson, Mitali ; Sedelnikova, Svetlana E ; Smither, Sophie J ; Tan, Patrick ; Titball, Richard W ; Wilson, Stuart A ; Rice, David W
contributorCruz-Migoni, Abimael (correspondence author) ; Cruz-Migoni, Abimael (record owner)
ispartofScience (New York, N.Y.), November 11, 2011, Vol.334(6057), pp.821-824
identifierE-ISSN: 1095-9203 ; DOI: 10.1126/science.1211915
subjectAmino Acid Motifs–Chemistry ; Animals–Genetics ; Bacterial Proteins–Metabolism ; Bacterial Toxins–Toxicity ; Burkholderia Pseudomallei–Chemistry ; Catalytic Domain–Genetics ; Cell Line–Metabolism ; Crystallography, X-Ray–Toxicity ; Cytotoxins–Chemistry ; Escherichia Coli Proteins–Pathogenicity ; Eukaryotic Initiation Factor-4a–Chemistry ; Glutamine–Genetics ; Humans–Metabolism ; Mice–Toxicity ; Mice, Inbred Balb C–Chemistry ; Models, Molecular–Antagonists & Inhibitors ; Mutant Proteins–Metabolism ; Peptide Chain Initiation, Translational–Metabolism ; Protein Binding–Toxicity ; Protein Conformation–Drug Effects ; Protein Structure, Secondary–Drug Effects ; Protein Structure, Tertiary–Drug Effects ; Bpsl1549 Protein, Burkholderia Pseudomallei ; Bacterial Proteins ; Bacterial Toxins ; Cytotoxins ; Escherichia Coli Proteins ; Mutant Proteins ; Glutamine ; Cytotoxic Necrotizing Factor Type 1 ; Eukaryotic Initiation Factor-4a
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23Smither, Sophie J
24Tan, Patrick
25Titball, Richard W
26Wilson, Stuart A
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titleA Burkholderia pseudomallei toxin inhibits helicase activity of translation factor eIF4A.
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1Animals–Genetics
2Bacterial Proteins–Metabolism
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9Escherichia Coli Proteins–Pathogenicity
10Eukaryotic Initiation Factor-4a–Chemistry
11Glutamine–Genetics
12Humans–Metabolism
13Mice–Toxicity
14Mice, Inbred Balb C–Chemistry
15Models, Molecular–Antagonists & Inhibitors
16Mutant Proteins–Metabolism
17Peptide Chain Initiation, Translational–Metabolism
18Protein Binding–Toxicity
19Protein Conformation–Drug Effects
20Protein Structure, Secondary–Drug Effects
21Protein Structure, Tertiary–Drug Effects
22Bpsl1549 Protein, Burkholderia Pseudomallei
23Bacterial Proteins
24Bacterial Toxins
25Cytotoxins
26Escherichia Coli Proteins
27Mutant Proteins
28Glutamine
29Cytotoxic Necrotizing Factor Type 1
30Eukaryotic Initiation Factor-4a
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titleA Burkholderia pseudomallei toxin inhibits helicase activity of translation factor eIF4A.
authorCruz-Migoni, Abimael ; Hautbergue, Guillaume M ; Artymiuk, Peter J ; Baker, Patrick J ; Bokori-Brown, Monika ; Chang, Chung-Te ; Dickman, Mark J ; Essex-Lopresti, Angela ; Harding, Sarah V ; Mahadi, Nor Muhammad ; Marshall, Laura E ; Mobbs, George W ; Mohamed, Rahmah ; Nathan, Sheila ; Ngugi, Sarah A ; Ong, Catherine ; Ooi, Wen Fong ; Partridge, Lynda J ; Phillips, Helen L ; Raih, M Firdaus ; Ruzheinikov, Sergei ; Sarkar-Tyson, Mitali ; Sedelnikova, Svetlana E ; Smither, Sophie J ; Tan, Patrick ; Titball, Richard W ; Wilson, Stuart A ; Rice, David W
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4Burkholderia Pseudomallei–Chemistry
5Catalytic Domain–Genetics
6Cell Line–Metabolism
7Crystallography, X-Ray–Toxicity
8Cytotoxins–Chemistry
9Escherichia Coli Proteins–Pathogenicity
10Eukaryotic Initiation Factor-4a–Chemistry
11Glutamine–Genetics
12Humans–Metabolism
13Mice–Toxicity
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15Models, Molecular–Antagonists & Inhibitors
16Mutant Proteins–Metabolism
17Peptide Chain Initiation, Translational–Metabolism
18Protein Binding–Toxicity
19Protein Conformation–Drug Effects
20Protein Structure, Secondary–Drug Effects
21Protein Structure, Tertiary–Drug Effects
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24Bacterial Toxins
25Cytotoxins
26Escherichia Coli Proteins
27Mutant Proteins
28Glutamine
29Cytotoxic Necrotizing Factor Type 1
30Eukaryotic Initiation Factor-4a
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16Ooi, Wen Fong
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