schliessen

Filtern

 

Bibliotheken

Association of mitochondrial DNA content in peripheral blood leukocyte with hepatitis B virus-related hepatocellular carcinoma in a Chinese Han population

Increasing epidemiological evidence has indicated that inherited variations of mtDNA content could affect the genetic susceptibility of many malignancies in a tumor-specific manner. However, the association between mtDNA content and hepatocellular carcinoma (HCC) remains undetermined. In this study,... Full description

Journal Title: Cancer Science Aug 2011, Vol.102(8), pp.1553-1558
Main Author: Zhao, Siyuan
Other Authors: Yang, Yefa , Liu, Juan , Liu, Hanqiang , Ge, Naijian , Yang, Hushan , Zhang, Hongxin , Xing, Jinliang
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: © ProQuest LLC All rights reserved
ID: ISSN: 1347-9032 ; E-ISSN: 1349-7006 ; DOI: 10.1111/j.1349-7006.2011.01968.x
Link: http://search.proquest.com/docview/904477427/
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: proquest904477427
title: Association of mitochondrial DNA content in peripheral blood leukocyte with hepatitis B virus-related hepatocellular carcinoma in a Chinese Han population
format: Article
creator:
  • Zhao, Siyuan
  • Yang, Yefa
  • Liu, Juan
  • Liu, Hanqiang
  • Ge, Naijian
  • Yang, Hushan
  • Zhang, Hongxin
  • Xing, Jinliang
subjects:
  • Malignancy
  • Mitochondrial DNA
  • Liver Diseases
  • Leukocytes
  • Hepatitis B
  • Polymerase Chain Reaction
  • Peripheral Blood
  • Hepatocellular Carcinoma
  • Hepatitis B
  • Hepatocellular Carcinoma
  • Leukocytes
  • Liver Diseases
  • Malignancy
  • Mitochondrial DNA
  • Peripheral Blood
  • Polymerase Chain Reaction
  • Oncology
  • Miscellaneous
ispartof: Cancer Science, Aug 2011, Vol.102(8), pp.1553-1558
description: Increasing epidemiological evidence has indicated that inherited variations of mtDNA content could affect the genetic susceptibility of many malignancies in a tumor-specific manner. However, the association between mtDNA content and hepatocellular carcinoma (HCC) remains undetermined. In this study, mtDNA content of peripheral blood leukocytes was determined using quantitative real-time PCR in a case-control study consisting of 274 HCC cases, 126 non-cancer patient controls with chronic liver diseases (CLD), and 258 healthy controls. We found that HCC cases had a significant lower mtDNA content than CLD controls (median [range]: 0.77 [0.17-2.30] vs 0.84 [0.32-3.37]; P=0.012) and healthy controls (0.77 [0.17-2.30] vs 0.84 [0.35-3.44]; P=0.035). There was no difference in mtDNA content between CLD and healthy controls (0.84 [0.32-3.37] vs 0.84 [0.35-3.44]; P=0.261). We further assessed the association between mtDNA content and HCC and found that, compared to individuals with high mtDNA content, those with low mtDNA content had a significantly increased risk of HCC when health controls (adjusted odds ratio [aOR]=1.64, 95% confidence interval [CI]=1.06-2.55), CLD controls (aOR=1.57, 95% CI=1.10-2.25) or combined controls (aOR=1.55, 95% CI=1.12-2.14) were used as reference. In addition, stratified analyses showed that the significant association was only evident in younger individuals, male individuals, ever-smokers, and never-drinkers. Collectively, our findings provided the first epidemiological evidence that mtDNA content in peripheral blood leukocytes is significantly associated with HCC, which warrants further validation in prospective studies. (Cancer Sci 2011; 102: 1553-1558)
language: eng
source: © ProQuest LLC All rights reserved
identifier: ISSN: 1347-9032 ; E-ISSN: 1349-7006 ; DOI: 10.1111/j.1349-7006.2011.01968.x
fulltext: fulltext
issn:
  • 13479032
  • 1347-9032
  • 13497006
  • 1349-7006
url: Link


@attributes
ID656147525
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid904477427
sourceidproquest
recordidTN_proquest904477427
sourcesystemOther
pqid904477427
display
typearticle
titleAssociation of mitochondrial DNA content in peripheral blood leukocyte with hepatitis B virus-related hepatocellular carcinoma in a Chinese Han population
creatorZhao, Siyuan ; Yang, Yefa ; Liu, Juan ; Liu, Hanqiang ; Ge, Naijian ; Yang, Hushan ; Zhang, Hongxin ; Xing, Jinliang
contributorZhao, Siyuan (correspondence author)
ispartofCancer Science, Aug 2011, Vol.102(8), pp.1553-1558
identifier
subjectMalignancy ; Mitochondrial DNA ; Liver Diseases ; Leukocytes ; Hepatitis B ; Polymerase Chain Reaction ; Peripheral Blood ; Hepatocellular Carcinoma ; Hepatitis B ; Hepatocellular Carcinoma ; Leukocytes ; Liver Diseases ; Malignancy ; Mitochondrial DNA ; Peripheral Blood ; Polymerase Chain Reaction ; Oncology ; Miscellaneous
descriptionIncreasing epidemiological evidence has indicated that inherited variations of mtDNA content could affect the genetic susceptibility of many malignancies in a tumor-specific manner. However, the association between mtDNA content and hepatocellular carcinoma (HCC) remains undetermined. In this study, mtDNA content of peripheral blood leukocytes was determined using quantitative real-time PCR in a case-control study consisting of 274 HCC cases, 126 non-cancer patient controls with chronic liver diseases (CLD), and 258 healthy controls. We found that HCC cases had a significant lower mtDNA content than CLD controls (median [range]: 0.77 [0.17-2.30] vs 0.84 [0.32-3.37]; P=0.012) and healthy controls (0.77 [0.17-2.30] vs 0.84 [0.35-3.44]; P=0.035). There was no difference in mtDNA content between CLD and healthy controls (0.84 [0.32-3.37] vs 0.84 [0.35-3.44]; P=0.261). We further assessed the association between mtDNA content and HCC and found that, compared to individuals with high mtDNA content, those with low mtDNA content had a significantly increased risk of HCC when health controls (adjusted odds ratio [aOR]=1.64, 95% confidence interval [CI]=1.06-2.55), CLD controls (aOR=1.57, 95% CI=1.10-2.25) or combined controls (aOR=1.55, 95% CI=1.12-2.14) were used as reference. In addition, stratified analyses showed that the significant association was only evident in younger individuals, male individuals, ever-smokers, and never-drinkers. Collectively, our findings provided the first epidemiological evidence that mtDNA content in peripheral blood leukocytes is significantly associated with HCC, which warrants further validation in prospective studies. (Cancer Sci 2011; 102: 1553-1558)
languageeng
source
0© ProQuest LLC All rights reserved
1ProQuest Biological Science Collection
2ProQuest Natural Science Collection
3ProQuest SciTech Collection
4Biological Science Database
5Natural Science Collection
6SciTech Premium Collection
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
backlink$$Uhttp://search.proquest.com/docview/904477427/$$EView_record_in_ProQuest_(subscribers_only)
search
creatorcontrib
0Zhao, Siyuan
1Yang, Yefa
2Liu, Juan
3Liu, Hanqiang
4Ge, Naijian
5Yang, Hushan
6Zhang, Hongxin
7Xing, Jinliang
titleAssociation of mitochondrial DNA content in peripheral blood leukocyte with hepatitis B virus-related hepatocellular carcinoma in a Chinese Han population
descriptionIncreasing epidemiological evidence has indicated that inherited variations of mtDNA content could affect the genetic susceptibility of many malignancies in a tumor-specific manner. However, the association between mtDNA content and hepatocellular carcinoma (HCC) remains undetermined. In this study, mtDNA content of peripheral blood leukocytes was determined using quantitative real-time PCR in a case-control study consisting of 274 HCC cases, 126 non-cancer patient controls with chronic liver diseases (CLD), and 258 healthy controls. We found that HCC cases had a significant lower mtDNA content than CLD controls (median [range]: 0.77 [0.17-2.30] vs 0.84 [0.32-3.37]; P=0.012) and healthy controls (0.77 [0.17-2.30] vs 0.84 [0.35-3.44]; P=0.035). There was no difference in mtDNA content between CLD and healthy controls (0.84 [0.32-3.37] vs 0.84 [0.35-3.44]; P=0.261). We further assessed the association between mtDNA content and HCC and found that, compared to individuals with high mtDNA content, those with low mtDNA content had a significantly increased risk of HCC when health controls (adjusted odds ratio [aOR]=1.64, 95% confidence interval [CI]=1.06-2.55), CLD controls (aOR=1.57, 95% CI=1.10-2.25) or combined controls (aOR=1.55, 95% CI=1.12-2.14) were used as reference. In addition, stratified analyses showed that the significant association was only evident in younger individuals, male individuals, ever-smokers, and never-drinkers. Collectively, our findings provided the first epidemiological evidence that mtDNA content in peripheral blood leukocytes is significantly associated with HCC, which warrants further validation in prospective studies. (Cancer Sci 2011; 102: 1553-1558)
subject
0Malignancy
1Mitochondrial DNA
2Liver Diseases
3Leukocytes
4Hepatitis B
5Polymerase Chain Reaction
6Peripheral Blood
7Hepatocellular Carcinoma
8Oncology
9Miscellaneous
10V 22370
11N 14845
general
0English
110.1111/j.1349-7006.2011.01968.x
2ProQuest Biological Science Collection
3ProQuest Natural Science Collection
4ProQuest SciTech Collection
5Biological Science Database
6Natural Science Collection
7SciTech Premium Collection
sourceidproquest
recordidproquest904477427
issn
013479032
11347-9032
213497006
31349-7006
rsrctypearticle
creationdate2011
addtitleCancer Science
searchscope
01007490
11007538
21007944
310000002
410000004
510000038
610000050
710000120
810000198
910000209
1010000217
1110000238
1210000253
1310000260
14proquest
scope
01007490
11007538
21007944
310000002
410000004
510000038
610000050
710000120
810000198
910000209
1010000217
1110000238
1210000253
1310000260
14proquest
lsr43
01007490false
11007538false
21007944false
310000002false
410000004false
510000038false
610000050false
710000120false
810000198false
910000209false
1010000217false
1110000238false
1210000253false
1310000260false
contributorZhao, Siyuan
startdate20110801
enddate20110801
citationpf 1553 pt 1558 vol 102 issue 8
sort
titleAssociation of mitochondrial DNA content in peripheral blood leukocyte with hepatitis B virus-related hepatocellular carcinoma in a Chinese Han population
authorZhao, Siyuan ; Yang, Yefa ; Liu, Juan ; Liu, Hanqiang ; Ge, Naijian ; Yang, Hushan ; Zhang, Hongxin ; Xing, Jinliang
creationdate20110801
lso0120110801
facets
frbrgroupid7819521828529508981
frbrtype5
languageeng
creationdate2011
topic
0Malignancy
1Mitochondrial DNA
2Liver Diseases
3Leukocytes
4Hepatitis B
5Polymerase Chain Reaction
6Peripheral Blood
7Hepatocellular Carcinoma
8Oncology
9Miscellaneous
collection
0ProQuest Biological Science Collection
1ProQuest Natural Science Collection
2ProQuest SciTech Collection
3Biological Science Database
4Natural Science Collection
5SciTech Premium Collection
prefilterarticles
rsrctypearticles
creatorcontrib
0Zhao, Siyuan
1Yang, Yefa
2Liu, Juan
3Liu, Hanqiang
4Ge, Naijian
5Yang, Hushan
6Zhang, Hongxin
7Xing, Jinliang
jtitleCancer Science
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Zhao
1Yang
2Liu
3Ge
4Zhang
5Xing
aufirst
0Siyuan
1Yefa
2Juan
3Hanqiang
4Naijian
5Hushan
6Hongxin
7Jinliang
au
0Zhao, Siyuan
1Yang, Yefa
2Liu, Juan
3Liu, Hanqiang
4Ge, Naijian
5Yang, Hushan
6Zhang, Hongxin
7Xing, Jinliang
addauZhao, Siyuan
atitleAssociation of mitochondrial DNA content in peripheral blood leukocyte with hepatitis B virus-related hepatocellular carcinoma in a Chinese Han population
jtitleCancer Science
risdate20110801
volume102
issue8
spage1553
epage1558
pages1553-1558
issn1347-9032
eissn1349-7006
formatjournal
genrearticle
ristypeJOUR
abstractIncreasing epidemiological evidence has indicated that inherited variations of mtDNA content could affect the genetic susceptibility of many malignancies in a tumor-specific manner. However, the association between mtDNA content and hepatocellular carcinoma (HCC) remains undetermined. In this study, mtDNA content of peripheral blood leukocytes was determined using quantitative real-time PCR in a case-control study consisting of 274 HCC cases, 126 non-cancer patient controls with chronic liver diseases (CLD), and 258 healthy controls. We found that HCC cases had a significant lower mtDNA content than CLD controls (median [range]: 0.77 [0.17-2.30] vs 0.84 [0.32-3.37]; P=0.012) and healthy controls (0.77 [0.17-2.30] vs 0.84 [0.35-3.44]; P=0.035). There was no difference in mtDNA content between CLD and healthy controls (0.84 [0.32-3.37] vs 0.84 [0.35-3.44]; P=0.261). We further assessed the association between mtDNA content and HCC and found that, compared to individuals with high mtDNA content, those with low mtDNA content had a significantly increased risk of HCC when health controls (adjusted odds ratio [aOR]=1.64, 95% confidence interval [CI]=1.06-2.55), CLD controls (aOR=1.57, 95% CI=1.10-2.25) or combined controls (aOR=1.55, 95% CI=1.12-2.14) were used as reference. In addition, stratified analyses showed that the significant association was only evident in younger individuals, male individuals, ever-smokers, and never-drinkers. Collectively, our findings provided the first epidemiological evidence that mtDNA content in peripheral blood leukocytes is significantly associated with HCC, which warrants further validation in prospective studies. (Cancer Sci 2011; 102: 1553-1558)
doi10.1111/j.1349-7006.2011.01968.x
urlhttp://search.proquest.com/docview/904477427/
date2011-08-01