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Joint association of glycemic load and alcohol intake with type 2 diabetes incidence in women.

BACKGROUNDLittle is known about the joint association between glycemic index (GI), glycemic load (GL), and alcohol intake with type 2 diabetes (T2D). OBJECTIVEThe objective of this study was to examine whether alcohol intake alters the associations between carbohydrate quality (GI) or quality and qu... Full description

Journal Title: The American journal of clinical nutrition December 2011, Vol.94(6), pp.1525-1532
Main Author: Mekary, Rania A
Other Authors: Rimm, Eric B , Giovannucci, Edward , Stampfer, Meir J , Willett, Walter C , Ludwig, David S , Hu, Frank B
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1938-3207 ; DOI: 1938-3207 ; DOI: 10.3945/ajcn.111.023754
Link: http://search.proquest.com/docview/905871393/?pq-origsite=primo
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title: Joint association of glycemic load and alcohol intake with type 2 diabetes incidence in women.
format: Article
creator:
  • Mekary, Rania A
  • Rimm, Eric B
  • Giovannucci, Edward
  • Stampfer, Meir J
  • Willett, Walter C
  • Ludwig, David S
  • Hu, Frank B
subjects:
  • Adult–Metabolism
  • Alcohol Drinking–Metabolism
  • Blood Glucose–Blood
  • Diabetes Mellitus, Type 2–Metabolism
  • Diet Surveys–Metabolism
  • Dietary Carbohydrates–Pharmacology
  • Ethanol–Drug Effects
  • Female–Drug Effects
  • Follow-Up Studies–Drug Effects
  • Glycemic Index–Drug Effects
  • Humans–Drug Effects
  • Incidence–Drug Effects
  • Longitudinal Studies–Drug Effects
  • Middle Aged–Drug Effects
  • Proportional Hazards Models–Drug Effects
  • Surveys and Questionnaires–Drug Effects
  • Abridged
  • Blood Glucose
  • Dietary Carbohydrates
  • Ethanol
ispartof: The American journal of clinical nutrition, December 2011, Vol.94(6), pp.1525-1532
description: BACKGROUNDLittle is known about the joint association between glycemic index (GI), glycemic load (GL), and alcohol intake with type 2 diabetes (T2D). OBJECTIVEThe objective of this study was to examine whether alcohol intake alters the associations between carbohydrate quality (GI) or quality and quantity (GL) and T2D incidence in women. DESIGNParticipants from the Nurses' Health Study who were free of T2D, cardiovascular disease, or cancer (n = 81,827) at baseline in 1980 were followed for 26 y. Cumulative averages of GI, GL, total carbohydrates, and alcohol intake were calculated every 2-4 y from validated food-frequency questionnaires. Cox proportional hazard models were used to adjust for covariates. RESULTSWe documented 6950 cases of T2D during follow-up. After adjustment for lifestyle and dietary factors, the positive association between GL and T2D risk was attenuated in subjects with higher alcohol intakes. RRs that compared the top and bottom quintiles of GL were 1.29 (95% CI: 1.11, 1.49; P-trend < 0.001) in women with alcohol intakes of 0 to
language: eng
source:
identifier: E-ISSN: 1938-3207 ; DOI: 1938-3207 ; DOI: 10.3945/ajcn.111.023754
fulltext: fulltext
issn:
  • 19383207
  • 1938-3207
url: Link


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titleJoint association of glycemic load and alcohol intake with type 2 diabetes incidence in women.
creatorMekary, Rania A ; Rimm, Eric B ; Giovannucci, Edward ; Stampfer, Meir J ; Willett, Walter C ; Ludwig, David S ; Hu, Frank B
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ispartofThe American journal of clinical nutrition, December 2011, Vol.94(6), pp.1525-1532
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subjectAdult–Metabolism ; Alcohol Drinking–Metabolism ; Blood Glucose–Blood ; Diabetes Mellitus, Type 2–Metabolism ; Diet Surveys–Metabolism ; Dietary Carbohydrates–Pharmacology ; Ethanol–Drug Effects ; Female–Drug Effects ; Follow-Up Studies–Drug Effects ; Glycemic Index–Drug Effects ; Humans–Drug Effects ; Incidence–Drug Effects ; Longitudinal Studies–Drug Effects ; Middle Aged–Drug Effects ; Proportional Hazards Models–Drug Effects ; Surveys and Questionnaires–Drug Effects ; Abridged ; Blood Glucose ; Dietary Carbohydrates ; Ethanol
descriptionBACKGROUNDLittle is known about the joint association between glycemic index (GI), glycemic load (GL), and alcohol intake with type 2 diabetes (T2D). OBJECTIVEThe objective of this study was to examine whether alcohol intake alters the associations between carbohydrate quality (GI) or quality and quantity (GL) and T2D incidence in women. DESIGNParticipants from the Nurses' Health Study who were free of T2D, cardiovascular disease, or cancer (n = 81,827) at baseline in 1980 were followed for 26 y. Cumulative averages of GI, GL, total carbohydrates, and alcohol intake were calculated every 2-4 y from validated food-frequency questionnaires. Cox proportional hazard models were used to adjust for covariates. RESULTSWe documented 6950 cases of T2D during follow-up. After adjustment for lifestyle and dietary factors, the positive association between GL and T2D risk was attenuated in subjects with higher alcohol intakes. RRs that compared the top and bottom quintiles of GL were 1.29 (95% CI: 1.11, 1.49; P-trend < 0.001) in women with alcohol intakes of 0 to <5 g/d, 1.34 (95% CI: 0.93, 1.92; P-trend = 0.05) in women with alcohol intakes of 5 to <15 g/d, and 0.99 (95% CI: 0.60, 1.65; P-trend = 0.82) in women with alcohol intakes ≥15 g/d (P-interaction = 0.02). However, a higher intake of alcohol did not modify the positive association between GI and T2D (P-interaction = 0.76). CONCLUSIONOur findings suggest that a higher alcohol intake (≥15 g/d) attenuates the positive association between GL and T2D incidence.
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titleJoint association of glycemic load and alcohol intake with type 2 diabetes incidence in women.
descriptionBACKGROUNDLittle is known about the joint association between glycemic index (GI), glycemic load (GL), and alcohol intake with type 2 diabetes (T2D). OBJECTIVEThe objective of this study was to examine whether alcohol intake alters the associations between carbohydrate quality (GI) or quality and quantity (GL) and T2D incidence in women. DESIGNParticipants from the Nurses' Health Study who were free of T2D, cardiovascular disease, or cancer (n = 81,827) at baseline in 1980 were followed for 26 y. Cumulative averages of GI, GL, total carbohydrates, and alcohol intake were calculated every 2-4 y from validated food-frequency questionnaires. Cox proportional hazard models were used to adjust for covariates. RESULTSWe documented 6950 cases of T2D during follow-up. After adjustment for lifestyle and dietary factors, the positive association between GL and T2D risk was attenuated in subjects with higher alcohol intakes. RRs that compared the top and bottom quintiles of GL were 1.29 (95% CI: 1.11, 1.49; P-trend < 0.001) in women with alcohol intakes of 0 to <5 g/d, 1.34 (95% CI: 0.93, 1.92; P-trend = 0.05) in women with alcohol intakes of 5 to <15 g/d, and 0.99 (95% CI: 0.60, 1.65; P-trend = 0.82) in women with alcohol intakes ≥15 g/d (P-interaction = 0.02). However, a higher intake of alcohol did not modify the positive association between GI and T2D (P-interaction = 0.76). CONCLUSIONOur findings suggest that a higher alcohol intake (≥15 g/d) attenuates the positive association between GL and T2D incidence.
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titleJoint association of glycemic load and alcohol intake with type 2 diabetes incidence in women.
authorMekary, Rania A ; Rimm, Eric B ; Giovannucci, Edward ; Stampfer, Meir J ; Willett, Walter C ; Ludwig, David S ; Hu, Frank B
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abstractBACKGROUNDLittle is known about the joint association between glycemic index (GI), glycemic load (GL), and alcohol intake with type 2 diabetes (T2D). OBJECTIVEThe objective of this study was to examine whether alcohol intake alters the associations between carbohydrate quality (GI) or quality and quantity (GL) and T2D incidence in women. DESIGNParticipants from the Nurses' Health Study who were free of T2D, cardiovascular disease, or cancer (n = 81,827) at baseline in 1980 were followed for 26 y. Cumulative averages of GI, GL, total carbohydrates, and alcohol intake were calculated every 2-4 y from validated food-frequency questionnaires. Cox proportional hazard models were used to adjust for covariates. RESULTSWe documented 6950 cases of T2D during follow-up. After adjustment for lifestyle and dietary factors, the positive association between GL and T2D risk was attenuated in subjects with higher alcohol intakes. RRs that compared the top and bottom quintiles of GL were 1.29 (95% CI: 1.11, 1.49; P-trend < 0.001) in women with alcohol intakes of 0 to <5 g/d, 1.34 (95% CI: 0.93, 1.92; P-trend = 0.05) in women with alcohol intakes of 5 to <15 g/d, and 0.99 (95% CI: 0.60, 1.65; P-trend = 0.82) in women with alcohol intakes ≥15 g/d (P-interaction = 0.02). However, a higher intake of alcohol did not modify the positive association between GI and T2D (P-interaction = 0.76). CONCLUSIONOur findings suggest that a higher alcohol intake (≥15 g/d) attenuates the positive association between GL and T2D incidence.
doi10.3945/ajcn.111.023754
urlhttp://search.proquest.com/docview/905871393/
issn00029165
date2011-12-01