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A meta-analysis shows that docosahexaenoic acid from algal oil reduces serum triglycerides and increases HDL-cholesterol and LDL-cholesterol in persons without coronary heart disease.

Certain algae contain the (n-3) fatty acid DHA, yet the relation between algal oil supplementation and cardiovascular disease risk factors has not been systematically examined. Our objective was to examine the relation between algal oil supplementation and cardiovascular disease risk factors. We con... Full description

Journal Title: The Journal of nutrition January 2012, Vol.142(1), pp.99-104
Main Author: Bernstein, Adam M
Other Authors: Ding, Eric L , Willett, Walter C , Rimm, Eric B
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1541-6100 ; DOI: 10.3945/jn.111.148973
Link: http://search.proquest.com/docview/912429455/?pq-origsite=primo
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title: A meta-analysis shows that docosahexaenoic acid from algal oil reduces serum triglycerides and increases HDL-cholesterol and LDL-cholesterol in persons without coronary heart disease.
format: Article
creator:
  • Bernstein, Adam M
  • Ding, Eric L
  • Willett, Walter C
  • Rimm, Eric B
subjects:
  • Cholesterol, HDL–Blood
  • Cholesterol, LDL–Blood
  • Coronary Disease–Blood
  • Docosahexaenoic Acids–Isolation & Purification
  • Humans–Pharmacology
  • Plant Oils–Chemistry
  • Triglycerides–Blood
  • Cholesterol, HDL
  • Cholesterol, LDL
  • Plant Oils
  • Triglycerides
  • Docosahexaenoic Acids
ispartof: The Journal of nutrition, January 2012, Vol.142(1), pp.99-104
description: Certain algae contain the (n-3) fatty acid DHA, yet the relation between algal oil supplementation and cardiovascular disease risk factors has not been systematically examined. Our objective was to examine the relation between algal oil supplementation and cardiovascular disease risk factors. We conducted a systematic review of randomized controlled trials published between 1996 and 2011 examining the relation between algal oil supplementation and cardiovascular disease risk factors and performed a meta-analysis of the association between algal oil DHA supplementation and changes in the concentrations of TG, LDL-cholesterol (LDL-C), and HDL-cholesterol (HDL-C). We identified 11 randomized controlled trials with 485 healthy participants that evaluated the relation between algal oil DHA supplementation and TG, LDL-C, and HDL-C. The median dose of algal DHA was 1.68 g/d. The pooled estimate for the change in TG concentration was -0.20 mmol/L (95% CI: -0.27 to -0.14), 0.23 mmol/L (95% CI: 0.16-0.30) for LDL-C, and 0.07 mmol/L (95% CI: 0.05-0.10) for H DL-C. DHA supplementation from algal oil, a marine source of (no3) fatty acids not extracted from fish, may reduce serum TG and increase HDL-C and LDL-C in persons without coronary heart disease. doi: 10.3945/jn.111.148973.
language: eng
source:
identifier: E-ISSN: 1541-6100 ; DOI: 10.3945/jn.111.148973
fulltext: fulltext
issn:
  • 15416100
  • 1541-6100
url: Link


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titleA meta-analysis shows that docosahexaenoic acid from algal oil reduces serum triglycerides and increases HDL-cholesterol and LDL-cholesterol in persons without coronary heart disease.
creatorBernstein, Adam M ; Ding, Eric L ; Willett, Walter C ; Rimm, Eric B
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identifierE-ISSN: 1541-6100 ; DOI: 10.3945/jn.111.148973
subjectCholesterol, HDL–Blood ; Cholesterol, LDL–Blood ; Coronary Disease–Blood ; Docosahexaenoic Acids–Isolation & Purification ; Humans–Pharmacology ; Plant Oils–Chemistry ; Triglycerides–Blood ; Cholesterol, HDL ; Cholesterol, LDL ; Plant Oils ; Triglycerides ; Docosahexaenoic Acids
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descriptionCertain algae contain the (n-3) fatty acid DHA, yet the relation between algal oil supplementation and cardiovascular disease risk factors has not been systematically examined. Our objective was to examine the relation between algal oil supplementation and cardiovascular disease risk factors. We conducted a systematic review of randomized controlled trials published between 1996 and 2011 examining the relation between algal oil supplementation and cardiovascular disease risk factors and performed a meta-analysis of the association between algal oil DHA supplementation and changes in the concentrations of TG, LDL-cholesterol (LDL-C), and HDL-cholesterol (HDL-C). We identified 11 randomized controlled trials with 485 healthy participants that evaluated the relation between algal oil DHA supplementation and TG, LDL-C, and HDL-C. The median dose of algal DHA was 1.68 g/d. The pooled estimate for the change in TG concentration was -0.20 mmol/L (95% CI: -0.27 to -0.14), 0.23 mmol/L (95% CI: 0.16-0.30) for LDL-C, and 0.07 mmol/L (95% CI: 0.05-0.10) for H DL-C. DHA supplementation from algal oil, a marine source of (no3) fatty acids not extracted from fish, may reduce serum TG and increase HDL-C and LDL-C in persons without coronary heart disease. doi: 10.3945/jn.111.148973.
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