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Dietary lipoic acid influences antioxidant capability and oxidative status of broilers.

The effects of lipoic acid (LA) on the antioxidant status of broilers were investigated. Birds (1 day old) were randomly assigned to four groups and fed corn-soybean diets supplemented with 0, 100, 200, 300 mg/kg LA, respectively. The feeding program included a starter diet from 1 to 21 days of age... Full description

Journal Title: International journal of molecular sciences 2011, Vol.12(12), pp.8476-8488
Main Author: Chen, Peng
Other Authors: Ma, Qiu-Gang , Ji, Cheng , Zhang, Jian-Yun , Zhao, Li-Hong , Zhang, Yong , Jie, Yong-Ze
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1422-0067 ; DOI: 1422-0067 ; DOI: 10.3390/ijms12128476
Link: http://search.proquest.com/docview/917855396/?pq-origsite=primo
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title: Dietary lipoic acid influences antioxidant capability and oxidative status of broilers.
format: Article
creator:
  • Chen, Peng
  • Ma, Qiu-Gang
  • Ji, Cheng
  • Zhang, Jian-Yun
  • Zhao, Li-Hong
  • Zhang, Yong
  • Jie, Yong-Ze
subjects:
  • Animals–Administration & Dosage
  • Antioxidants–Pharmacology
  • Chickens–Growth & Development
  • Dietary Supplements–Metabolism
  • Glutathione Peroxidase–Blood
  • Liver–Metabolism
  • Male–Drug Effects
  • Malondialdehyde–Growth & Development
  • Muscle, Skeletal–Metabolism
  • Oxidative Stress–Blood
  • Superoxide Dismutase–Metabolism
  • Thioctic Acid–Drug Effects
  • Thioctic Acid–Growth & Development
  • Thioctic Acid–Metabolism
  • Thioctic Acid–Drug Effects
  • Thioctic Acid–Blood
  • Thioctic Acid–Metabolism
  • Thioctic Acid–Administration & Dosage
  • Thioctic Acid–Pharmacology
  • Antioxidants
  • Malondialdehyde
  • Thioctic Acid
  • Glutathione Peroxidase
  • Superoxide Dismutase
  • Antioxidant Capability
  • Broiler
  • Lipoic Acid
ispartof: International journal of molecular sciences, 2011, Vol.12(12), pp.8476-8488
description: The effects of lipoic acid (LA) on the antioxidant status of broilers were investigated. Birds (1 day old) were randomly assigned to four groups and fed corn-soybean diets supplemented with 0, 100, 200, 300 mg/kg LA, respectively. The feeding program included a starter diet from 1 to 21 days of age and a grower diet from 22 to 42 days of age. Serum, liver and muscle samples were collected at 42 days of age. For antioxidant enzymes, superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activity in serum, liver and breast muscle significantly increased in chickens fed with LA. The concentration of malondiadehyde (MDA), an indicator of lipid peroxidation, was significantly lower in serum, liver and leg muscle in birds that received LA than in the control group. Treatments with LA significantly increased glutathione (GSH) content in liver and increased α-tocopherol content in leg muscle as compared to the control. These results indicate that dietary supplementation with 300 mg/kg LA may enhance antioxidant capability and depress oxidative stress in broilers.
language: eng
source:
identifier: E-ISSN: 1422-0067 ; DOI: 1422-0067 ; DOI: 10.3390/ijms12128476
fulltext: fulltext
issn:
  • 14220067
  • 1422-0067
url: Link


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titleDietary lipoic acid influences antioxidant capability and oxidative status of broilers.
creatorChen, Peng ; Ma, Qiu-Gang ; Ji, Cheng ; Zhang, Jian-Yun ; Zhao, Li-Hong ; Zhang, Yong ; Jie, Yong-Ze
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subjectAnimals–Administration & Dosage ; Antioxidants–Pharmacology ; Chickens–Growth & Development ; Dietary Supplements–Metabolism ; Glutathione Peroxidase–Blood ; Liver–Metabolism ; Male–Drug Effects ; Malondialdehyde–Growth & Development ; Muscle, Skeletal–Metabolism ; Oxidative Stress–Blood ; Superoxide Dismutase–Metabolism ; Thioctic Acid–Drug Effects ; Thioctic Acid–Growth & Development ; Thioctic Acid–Metabolism ; Thioctic Acid–Drug Effects ; Thioctic Acid–Blood ; Thioctic Acid–Metabolism ; Thioctic Acid–Administration & Dosage ; Thioctic Acid–Pharmacology ; Antioxidants ; Malondialdehyde ; Thioctic Acid ; Glutathione Peroxidase ; Superoxide Dismutase ; Antioxidant Capability ; Broiler ; Lipoic Acid
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descriptionThe effects of lipoic acid (LA) on the antioxidant status of broilers were investigated. Birds (1 day old) were randomly assigned to four groups and fed corn-soybean diets supplemented with 0, 100, 200, 300 mg/kg LA, respectively. The feeding program included a starter diet from 1 to 21 days of age and a grower diet from 22 to 42 days of age. Serum, liver and muscle samples were collected at 42 days of age. For antioxidant enzymes, superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activity in serum, liver and breast muscle significantly increased in chickens fed with LA. The concentration of malondiadehyde (MDA), an indicator of lipid peroxidation, was significantly lower in serum, liver and leg muscle in birds that received LA than in the control group. Treatments with LA significantly increased glutathione (GSH) content in liver and increased α-tocopherol content in leg muscle as compared to the control. These results indicate that dietary supplementation with 300 mg/kg LA may enhance antioxidant capability and depress oxidative stress in broilers.
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