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Uric acid in the early risk stratification of ST-elevation myocardial infarction

Controversy still exists about uric acid as a potential prognosticrisk factor for outcomes in patients with acute myocardial infarction. We prospectively assessed, in 856 patients with ST-elevation myocardial infarction (STMI) consecutively admitted to our Intensive Cardiac Care Unit after primary p... Full description

Journal Title: Internal and Emergency Medicine Feb 2012, Vol.7(1), pp.33-9
Main Author: Lazzeri, Chiara
Other Authors: Valente, Serafina , Chiostri, Marco , Picariello, Claudio , Gensini, Gian
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 18280447 ; E-ISSN: 19709366 ; DOI: 10.1007/s11739-011-0515-9
Link: http://search.proquest.com/docview/917876935/?pq-origsite=primo
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title: Uric acid in the early risk stratification of ST-elevation myocardial infarction
format: Article
creator:
  • Lazzeri, Chiara
  • Valente, Serafina
  • Chiostri, Marco
  • Picariello, Claudio
  • Gensini, Gian
subjects:
  • Age Factors–Methods
  • Aged–Mortality
  • Angioplasty, Balloon, Coronary–Blood
  • Angioplasty, Balloon, Coronary–Trends
  • Biological Markers–Blood
  • Cohort Studies–Diagnosis
  • Confidence Intervals–Mortality
  • Coronary Care Units–Therapy
  • Electrocardiography–Blood
  • Female–Blood
  • Follow-Up Studies–Blood
  • Hospital Mortality–Blood
  • Humans–Blood
  • Logistic Models–Blood
  • Male–Blood
  • Middle Aged–Blood
  • Myocardial Infarction–Blood
  • Myocardial Infarction–Blood
  • Myocardial Infarction–Blood
  • Myocardial Infarction
ispartof: Internal and Emergency Medicine, Feb 2012, Vol.7(1), pp.33-9
description: Controversy still exists about uric acid as a potential prognosticrisk factor for outcomes in patients with acute myocardial infarction. We prospectively assessed, in 856 patients with ST-elevation myocardial infarction (STMI) consecutively admitted to our Intensive Cardiac Care Unit after primary percutaneous coronary intervention (PCI) whether uric acid (UA) levels are associated with in-hospital mortality and complications. Killip classes III--IV were more frequent in the 3° UA tertile that was associated with the highest values of peak Tn I (p = 0.005), NT-proBNP (p < 0.001), and fibrinogen (p = 0.036). Uric acid was associated with mortality (crude OR: 1.24; 95% CI 1.03-1.51; p = 0.025), but, when adjusted for Tn I and renal failure (as inferred by eGFR
language: eng
source:
identifier: ISSN: 18280447 ; E-ISSN: 19709366 ; DOI: 10.1007/s11739-011-0515-9
fulltext: fulltext
issn:
  • 18280447
  • 1828-0447
  • 19709366
  • 1970-9366
url: Link


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titleUric acid in the early risk stratification of ST-elevation myocardial infarction
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subjectAge Factors–Methods ; Aged–Mortality ; Angioplasty, Balloon, Coronary–Blood ; Angioplasty, Balloon, Coronary–Trends ; Biological Markers–Blood ; Cohort Studies–Diagnosis ; Confidence Intervals–Mortality ; Coronary Care Units–Therapy ; Electrocardiography–Blood ; Female–Blood ; Follow-Up Studies–Blood ; Hospital Mortality–Blood ; Humans–Blood ; Logistic Models–Blood ; Male–Blood ; Middle Aged–Blood ; Myocardial Infarction–Blood ; Myocardial Infarction–Blood ; Myocardial Infarction–Blood ; Myocardial Infarction
descriptionControversy still exists about uric acid as a potential prognosticrisk factor for outcomes in patients with acute myocardial infarction. We prospectively assessed, in 856 patients with ST-elevation myocardial infarction (STMI) consecutively admitted to our Intensive Cardiac Care Unit after primary percutaneous coronary intervention (PCI) whether uric acid (UA) levels are associated with in-hospital mortality and complications. Killip classes III--IV were more frequent in the 3° UA tertile that was associated with the highest values of peak Tn I (p = 0.005), NT-proBNP (p < 0.001), and fibrinogen (p = 0.036). Uric acid was associated with mortality (crude OR: 1.24; 95% CI 1.03-1.51; p = 0.025), but, when adjusted for Tn I and renal failure (as inferred by eGFR <60 ml/min/1.73 m^sup 2^), uric acid lost its statistical significance, while Tn I (100 pg/ml step OR: 1.002; 95% CI 1.000-1.003; p = 0.007) and renal failure (OR 9.16; 95% CI 3.60-23.32; p < 0.001) were independent predictors for in-ICCU...
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titleUric acid in the early risk stratification of ST-elevation myocardial infarction
descriptionControversy still exists about uric acid as a potential prognosticrisk factor for outcomes in patients with acute myocardial infarction. We prospectively assessed, in 856 patients with ST-elevation myocardial infarction (STMI) consecutively admitted to our Intensive Cardiac Care Unit after primary percutaneous coronary intervention (PCI) whether uric acid (UA) levels are associated with in-hospital mortality and complications. Killip classes III--IV were more frequent in the 3° UA tertile that was associated with the highest values of peak Tn I (p = 0.005), NT-proBNP (p < 0.001), and fibrinogen (p = 0.036). Uric acid was associated with mortality (crude OR: 1.24; 95% CI 1.03-1.51; p = 0.025), but, when adjusted for Tn I and renal failure (as inferred by eGFR <60 ml/min/1.73 m^sup 2^), uric acid lost its statistical significance, while Tn I (100 pg/ml step OR: 1.002; 95% CI 1.000-1.003; p = 0.007) and renal failure (OR 9.16; 95% CI 3.60-23.32; p < 0.001) were independent predictors for in-ICCU...
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abstractControversy still exists about uric acid as a potential prognosticrisk factor for outcomes in patients with acute myocardial infarction. We prospectively assessed, in 856 patients with ST-elevation myocardial infarction (STMI) consecutively admitted to our Intensive Cardiac Care Unit after primary percutaneous coronary intervention (PCI) whether uric acid (UA) levels are associated with in-hospital mortality and complications. Killip classes III--IV were more frequent in the 3° UA tertile that was associated with the highest values of peak Tn I (p = 0.005), NT-proBNP (p < 0.001), and fibrinogen (p = 0.036). Uric acid was associated with mortality (crude OR: 1.24; 95% CI 1.03-1.51; p = 0.025), but, when adjusted for Tn I and renal failure (as inferred by eGFR <60 ml/min/1.73 m^sup 2^), uric acid lost its statistical significance, while Tn I (100 pg/ml step OR: 1.002; 95% CI 1.000-1.003; p = 0.007) and renal failure (OR 9.16; 95% CI 3.60-23.32; p < 0.001) were independent predictors for in-ICCU...
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