schliessen

Filtern

 

Bibliotheken

Impaired insulin sensitivity and elevated ectopic fat in healthy obese vs. nonobese prepubertal children.

Insulin sensitivity is impaired and ectopic fat (accretion of lipids outside of typical adipose tissue depots) increased in obese adults and adolescents. It is unknown how early in life this occurs; thus, it is important to evaluate young children to identify potential factors leading to the develop... Full description

Journal Title: Obesity (Silver Spring Md.), February 2012, Vol.20(2), pp.371-375
Main Author: Bennett, Brian
Other Authors: Larson-Meyer, D Enette , Ravussin, Eric , Volaufova, Julia , Soros, Arlette , Cefalu, William T , Chalew, Stuart , Gordon, Stewart , Smith, Steven R , Newcomer, Bradley R , Goran, Michael , Sothern, Melinda
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1930-739X ; DOI: 10.1038/oby.2011.264
Link: http://search.proquest.com/docview/918575778/?pq-origsite=primo
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: proquest918575778
title: Impaired insulin sensitivity and elevated ectopic fat in healthy obese vs. nonobese prepubertal children.
format: Article
creator:
  • Bennett, Brian
  • Larson-Meyer, D Enette
  • Ravussin, Eric
  • Volaufova, Julia
  • Soros, Arlette
  • Cefalu, William T
  • Chalew, Stuart
  • Gordon, Stewart
  • Smith, Steven R
  • Newcomer, Bradley R
  • Goran, Michael
  • Sothern, Melinda
subjects:
  • Absorptiometry, Photon–Metabolism
  • Blood Glucose–Physiology
  • Body Composition–Diagnosis
  • Child–Epidemiology
  • Cohort Studies–Metabolism
  • Cross-Sectional Studies–Blood
  • Fatty Liver–Diagnosis
  • Female–Epidemiology
  • Glucose Tolerance Test–Metabolism
  • Humans–Diagnosis
  • Insulin Resistance–Epidemiology
  • Lipids–Metabolism
  • Magnetic Resonance Spectroscopy–Metabolism
  • Male–Metabolism
  • Metabolic Syndrome–Metabolism
  • Obesity–Metabolism
  • Blood Glucose
  • Lipids
ispartof: Obesity (Silver Spring, Md.), February 2012, Vol.20(2), pp.371-375
description: Insulin sensitivity is impaired and ectopic fat (accretion of lipids outside of typical adipose tissue depots) increased in obese adults and adolescents. It is unknown how early in life this occurs; thus, it is important to evaluate young children to identify potential factors leading to the development of metabolic syndrome. We examined an ethnically diverse cohort of healthy, exclusively prepubertal children (N = 123; F = 57, M = 66; age 8.04 ± 0.77 years) to examine differences in insulin sensitivity and ectopic and visceral fat deposition between obese and nonobese youth. Obesity was categorized by age- and sex-adjusted BMI z-scores (nonobese = z-score
language: eng
source:
identifier: E-ISSN: 1930-739X ; DOI: 10.1038/oby.2011.264
fulltext: fulltext
issn:
  • 1930739X
  • 1930-739X
url: Link


@attributes
ID300950930
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid918575778
sourceidproquest
recordidTN_proquest918575778
sourcesystemPC
pqid918575778
display
typearticle
titleImpaired insulin sensitivity and elevated ectopic fat in healthy obese vs. nonobese prepubertal children.
creatorBennett, Brian ; Larson-Meyer, D Enette ; Ravussin, Eric ; Volaufova, Julia ; Soros, Arlette ; Cefalu, William T ; Chalew, Stuart ; Gordon, Stewart ; Smith, Steven R ; Newcomer, Bradley R ; Goran, Michael ; Sothern, Melinda
contributorBennett, Brian (correspondence author) ; Bennett, Brian (record owner)
ispartofObesity (Silver Spring, Md.), February 2012, Vol.20(2), pp.371-375
identifierE-ISSN: 1930-739X ; DOI: 10.1038/oby.2011.264
subjectAbsorptiometry, Photon–Metabolism ; Blood Glucose–Physiology ; Body Composition–Diagnosis ; Child–Epidemiology ; Cohort Studies–Metabolism ; Cross-Sectional Studies–Blood ; Fatty Liver–Diagnosis ; Female–Epidemiology ; Glucose Tolerance Test–Metabolism ; Humans–Diagnosis ; Insulin Resistance–Epidemiology ; Lipids–Metabolism ; Magnetic Resonance Spectroscopy–Metabolism ; Male–Metabolism ; Metabolic Syndrome–Metabolism ; Obesity–Metabolism ; Blood Glucose ; Lipids
languageeng
source
descriptionInsulin sensitivity is impaired and ectopic fat (accretion of lipids outside of typical adipose tissue depots) increased in obese adults and adolescents. It is unknown how early in life this occurs; thus, it is important to evaluate young children to identify potential factors leading to the development of metabolic syndrome. We examined an ethnically diverse cohort of healthy, exclusively prepubertal children (N = 123; F = 57, M = 66; age 8.04 ± 0.77 years) to examine differences in insulin sensitivity and ectopic and visceral fat deposition between obese and nonobese youth. Obesity was categorized by age- and sex-adjusted BMI z-scores (nonobese = z-score <2 (N = 94) and obese = z-score ≥2 (N = 29)). Insulin sensitivity was assessed by both a frequently sampled intravenous glucose tolerance test (S(i)) and the homeostatic model assessment of insulin resistance (HOMA(IR)). Intramyocellular lipids (IMCLs) from soleus and intrahepatic lipids (IHLs) were assessed by magnetic resonance spectroscopy, visceral adipose tissue (VAT) by magnetic resonance imaging, and total body fat by dual-energy X-ray absorptiometry. We also examined serum lipids (total cholesterol, triglycerides, high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol) and blood pressure (diastolic and systolic). Obese children exhibited significantly lower S(i) (5.9 ± 5.98 vs. 13.43 ± 8.18 (mµ/l)(-1)·min(-1), P = 0.01) and HDL-C and higher HOMA(IR) (1.68 ± 1.49 vs. 0.63 ± 0.47, P < 0.0001), IMCL (0.74 ± 0.39 vs. 0.44 ± 0.21% water peak, P < 0.0001), IHL (1.49 ± 1.13 vs. 0.54 ± 0.42% water peak, P < 0.0001), VAT (20.16 ± 8.01 vs. 10.62 ± 5.44 cm(2), P < 0.0001), total cholesterol, triglycerides, low-density lipoprotein cholesterol, and systolic blood pressure relative to nonobese children. These results confirm significantly increased ectopic fat and insulin resistance in healthy obese vs. nonobese children prior to puberty. Excessive adiposity during early development appears concomitant with precursors of type 2 diabetes and the metabolic syndrome.
version4
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
backlink$$Uhttp://search.proquest.com/docview/918575778/?pq-origsite=primo$$EView_record_in_ProQuest_(subscribers_only)
search
creatorcontrib
0Bennett, Brian
1Larson-Meyer, D Enette
2Ravussin, Eric
3Volaufova, Julia
4Soros, Arlette
5Cefalu, William T
6Chalew, Stuart
7Gordon, Stewart
8Smith, Steven R
9Newcomer, Bradley R
10Goran, Michael
11Sothern, Melinda
titleImpaired insulin sensitivity and elevated ectopic fat in healthy obese vs. nonobese prepubertal children.
subject
0Absorptiometry, Photon–Metabolism
1Blood Glucose–Physiology
2Body Composition–Diagnosis
3Child–Epidemiology
4Cohort Studies–Metabolism
5Cross-Sectional Studies–Blood
6Fatty Liver–Diagnosis
7Female–Epidemiology
8Glucose Tolerance Test–Metabolism
9Humans–Diagnosis
10Insulin Resistance–Epidemiology
11Lipids–Metabolism
12Magnetic Resonance Spectroscopy–Metabolism
13Male–Metabolism
14Metabolic Syndrome–Metabolism
15Obesity–Metabolism
16Blood Glucose
17Lipids
general
0English
110.1038/oby.2011.264
2MEDLINE (ProQuest)
3ProQuest Biological Science Collection
4ProQuest Natural Science Collection
5ProQuest SciTech Collection
6Biological Science Database
7Natural Science Collection
8SciTech Premium Collection
9Health Research Premium Collection
10Health Research Premium Collection (Alumni edition)
11Biological Science Index (ProQuest)
sourceidproquest
recordidproquest918575778
issn
01930739X
11930-739X
rsrctypearticle
creationdate2012
addtitleObesity (Silver Spring, Md.)
searchscope
01007527
11007944
21009130
310000004
410000038
510000050
610000120
710000159
810000238
910000253
1010000260
1110000270
1210000271
1310000302
1410000350
15proquest
scope
01007527
11007944
21009130
310000004
410000038
510000050
610000120
710000159
810000238
910000253
1010000260
1110000270
1210000271
1310000302
1410000350
15proquest
lsr43
01007527false
11007944false
21009130false
310000004false
410000038false
510000050false
610000120false
710000159false
810000238false
910000253false
1010000260false
1110000270false
1210000271false
1310000302false
1410000350false
contributorBennett, Brian
startdate20120201
enddate20120201
citationpf 371 pt 375 vol 20 issue 2
lsr30VSR-Enriched:[pqid, description, issn, date]
sort
titleImpaired insulin sensitivity and elevated ectopic fat in healthy obese vs. nonobese prepubertal children.
authorBennett, Brian ; Larson-Meyer, D Enette ; Ravussin, Eric ; Volaufova, Julia ; Soros, Arlette ; Cefalu, William T ; Chalew, Stuart ; Gordon, Stewart ; Smith, Steven R ; Newcomer, Bradley R ; Goran, Michael ; Sothern, Melinda
creationdate20120201
lso0120120201
facets
frbrgroupid8768124015684686381
frbrtype5
newrecords20181218
languageeng
creationdate2012
topic
0Absorptiometry, Photon–Metabolism
1Blood Glucose–Physiology
2Body Composition–Diagnosis
3Child–Epidemiology
4Cohort Studies–Metabolism
5Cross-Sectional Studies–Blood
6Fatty Liver–Diagnosis
7Female–Epidemiology
8Glucose Tolerance Test–Metabolism
9Humans–Diagnosis
10Insulin Resistance–Epidemiology
11Lipids–Metabolism
12Magnetic Resonance Spectroscopy–Metabolism
13Male–Metabolism
14Metabolic Syndrome–Metabolism
15Obesity–Metabolism
16Blood Glucose
17Lipids
collection
0MEDLINE (ProQuest)
1ProQuest Biological Science Collection
2ProQuest Natural Science Collection
3ProQuest SciTech Collection
4Biological Science Database
5Natural Science Collection
6SciTech Premium Collection
7Health Research Premium Collection
8Health Research Premium Collection (Alumni edition)
9Biological Science Index (ProQuest)
prefilterarticles
rsrctypearticles
creatorcontrib
0Bennett, Brian
1Larson-Meyer, D Enette
2Ravussin, Eric
3Volaufova, Julia
4Soros, Arlette
5Cefalu, William T
6Chalew, Stuart
7Gordon, Stewart
8Smith, Steven R
9Newcomer, Bradley R
10Goran, Michael
11Sothern, Melinda
jtitleObesity (Silver Spring, Md.)
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Bennett
1Larson-Meyer
2Ravussin
3Volaufova
4Soros
5Cefalu
6Chalew
7Gordon
8Smith
9Newcomer
10Goran
11Sothern
aufirst
0Brian
1D Enette
2Eric
3Julia
4Arlette
5William T
6Stuart
7Stewart
8Steven R
9Bradley R
10Michael
11Melinda
au
0Bennett, Brian
1Larson-Meyer, D Enette
2Ravussin, Eric
3Volaufova, Julia
4Soros, Arlette
5Cefalu, William T
6Chalew, Stuart
7Gordon, Stewart
8Smith, Steven R
9Newcomer, Bradley R
10Goran, Michael
11Sothern, Melinda
addauBennett, Brian
atitleImpaired insulin sensitivity and elevated ectopic fat in healthy obese vs. nonobese prepubertal children.
jtitleObesity (Silver Spring, Md.)
risdate20120201
volume20
issue2
spage371
epage375
pages371-375
eissn1930-739X
formatjournal
genrearticle
ristypeJOUR
doi10.1038/oby.2011.264
urlhttp://search.proquest.com/docview/918575778/
issn19307381
date2012-02