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Dietary magnesium intake and risk of stroke: a meta-analysis of prospective studies

Prospective studies of dietary magnesium intake in relation to risk of stroke have yielded inconsistent results. We conducted a dose-response meta-analysis to summarize the evidence regarding the association between magnesium intake and stroke risk. Relevant studies were identified by searching PubM... Full description

Journal Title: The American Journal of Clinical Nutrition Vol.95(2), p.362
Main Author: Larsson, Susanna
Other Authors: Orsini, Nicola , Wolk, Alicja
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: American Society for Clinical Nutrition, Inc.
Created: Feb 1, 2012
ID: ISSN: 00029165 ; E-ISSN: 19383207
Link: http://search.proquest.com/docview/922549710/?pq-origsite=primo
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title: Dietary magnesium intake and risk of stroke: a meta-analysis of prospective studies
format: Article
creator:
  • Larsson, Susanna
  • Orsini, Nicola
  • Wolk, Alicja
subjects:
  • Meta-Analysis
  • Magnesium
  • Diet
  • Stroke
  • Risk Factors
ispartof: The American Journal of Clinical Nutrition, Vol.95(2), p.362
description: Prospective studies of dietary magnesium intake in relation to risk of stroke have yielded inconsistent results. We conducted a dose-response meta-analysis to summarize the evidence regarding the association between magnesium intake and stroke risk. Relevant studies were identified by searching PubMed and EMBASE from January 1966 through September 2011 and reviewing reference lists of retrieved articles. We included prospective studies that reported RRs with 95% CIs of stroke for ≥3 categories of magnesium intake. Results from individual studies were combined by using a random-effects model. Seven prospective studies, with 6477 cases of stroke and 241,378 participants, were eligible for inclusion in the meta-analysis. We observed a modest but statistically significant inverse association between magnesium intake and risk of stroke. An intake increment of 100 mg Mg/d was associated with an 8% reduction in risk of total stroke (combined RR: 0.92; 95% CI: 0.88, 0.97), without heterogeneity among studies (P = 0.66, ... = 0%). Magnesium intake was inversely associated with risk of ischemic stroke (RR: 0.91; 95% CI: 0.87, 0.96) but not intracerebral hemorrhage (RR: 0.96; 95% CI: 0.84, 1.10) or subarachnoid hemorrhage (RR: 1.01; 95% CI: 0.90, 1.14). Dietary magnesium intake is inversely associated with risk of stroke, specifically ischemic stroke. (ProQuest: ... denotes formulae/symbols omitted.)
language: eng
source:
identifier: ISSN: 00029165 ; E-ISSN: 19383207
fulltext: fulltext
issn:
  • 00029165
  • 0002-9165
  • 19383207
  • 1938-3207
url: Link


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titleDietary magnesium intake and risk of stroke: a meta-analysis of prospective studies
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subjectMeta-Analysis ; Magnesium ; Diet ; Stroke ; Risk Factors
descriptionProspective studies of dietary magnesium intake in relation to risk of stroke have yielded inconsistent results. We conducted a dose-response meta-analysis to summarize the evidence regarding the association between magnesium intake and stroke risk. Relevant studies were identified by searching PubMed and EMBASE from January 1966 through September 2011 and reviewing reference lists of retrieved articles. We included prospective studies that reported RRs with 95% CIs of stroke for ≥3 categories of magnesium intake. Results from individual studies were combined by using a random-effects model. Seven prospective studies, with 6477 cases of stroke and 241,378 participants, were eligible for inclusion in the meta-analysis. We observed a modest but statistically significant inverse association between magnesium intake and risk of stroke. An intake increment of 100 mg Mg/d was associated with an 8% reduction in risk of total stroke (combined RR: 0.92; 95% CI: 0.88, 0.97), without heterogeneity among studies (P = 0.66, ... = 0%). Magnesium intake was inversely associated with risk of ischemic stroke (RR: 0.91; 95% CI: 0.87, 0.96) but not intracerebral hemorrhage (RR: 0.96; 95% CI: 0.84, 1.10) or subarachnoid hemorrhage (RR: 1.01; 95% CI: 0.90, 1.14). Dietary magnesium intake is inversely associated with risk of stroke, specifically ischemic stroke. (ProQuest: ... denotes formulae/symbols omitted.)
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abstractProspective studies of dietary magnesium intake in relation to risk of stroke have yielded inconsistent results. We conducted a dose-response meta-analysis to summarize the evidence regarding the association between magnesium intake and stroke risk. Relevant studies were identified by searching PubMed and EMBASE from January 1966 through September 2011 and reviewing reference lists of retrieved articles. We included prospective studies that reported RRs with 95% CIs of stroke for ≥3 categories of magnesium intake. Results from individual studies were combined by using a random-effects model. Seven prospective studies, with 6477 cases of stroke and 241,378 participants, were eligible for inclusion in the meta-analysis. We observed a modest but statistically significant inverse association between magnesium intake and risk of stroke. An intake increment of 100 mg Mg/d was associated with an 8% reduction in risk of total stroke (combined RR: 0.92; 95% CI: 0.88, 0.97), without heterogeneity among studies (P = 0.66, ... = 0%). Magnesium intake was inversely associated with risk of ischemic stroke (RR: 0.91; 95% CI: 0.87, 0.96) but not intracerebral hemorrhage (RR: 0.96; 95% CI: 0.84, 1.10) or subarachnoid hemorrhage (RR: 1.01; 95% CI: 0.90, 1.14). Dietary magnesium intake is inversely associated with risk of stroke, specifically ischemic stroke. (ProQuest: ... denotes formulae/symbols omitted.)
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