schliessen

Filtern

 

Bibliotheken

Associations of myostatin gene polymorphisms with performance and mortality traits in broiler chickens

Myostatin is a negative regulator of skeletal muscle growth. We evaluated effects of myostatin polymorphisms in three elite commercial broiler chicken lines on mortality, growth, feed conversion efficiency, ultrasound breast depth, breast percentage, eviscerated carcass weight, leg defects, blood ox... Full description

Journal Title: Genetics Selection, Evolution : GSE, 2007, Vol.39(1), p.73-89
Main Author: Ye, Xianghai
Other Authors: Brown, Stewart R , Nones, Kátia , Coutinho, Luiz L , Dekkers, Jack Cm , Lamont, Susan J
Format: Electronic Article Electronic Article
Language:
Subjects:
Snp
ID: ISSN: 0999-193X ; E-ISSN: 1297-9686 ; DOI: 10.1186/1297-9686-39-1-73 ; PMCID: 2739435 ; PMID: 17212949
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: pubmed_central2739435
title: Associations of myostatin gene polymorphisms with performance and mortality traits in broiler chickens
format: Article
creator:
  • Ye, Xianghai
  • Brown, Stewart R
  • Nones, Kátia
  • Coutinho, Luiz L
  • Dekkers, Jack Cm
  • Lamont, Susan J
subjects:
  • Research
  • Myostatin
  • Snp
  • Growth
  • Mortality
  • Broiler Chicken
ispartof: Genetics, Selection, Evolution : GSE, 2007, Vol.39(1), p.73-89
description: Myostatin is a negative regulator of skeletal muscle growth. We evaluated effects of myostatin polymorphisms in three elite commercial broiler chicken lines on mortality, growth, feed conversion efficiency, ultrasound breast depth, breast percentage, eviscerated carcass weight, leg defects, blood oxygen level, and hen antibody titer to infectious bursal disease virus vaccine. Progeny mean data adjusted for fixed and mate effects and DNA from 100 sires per line were used. Single nucleotide polymorphisms (SNPs) of the myostatin gene segregating in these lines were identified by designing specific primers, amplifying individual DNA in each line by polymerase chain reaction, cloning, sequencing and aligning the corresponding products. Individual sires were genotyped for five identified SNPs which contributed to eight haplotypes. Frequencies of SNP alleles and haplotypes differed between lines. Using the allele substitution effect model, the myostatin SNPs were found to have significant ( P < 0.031) associations with growth, mortality, blood oxygen and hen antibody titer to infectious bursal disease virus vaccine, although the associations were not often consistent across lines. These results suggest that the myostatin gene has pleiotropic effects on broiler performance.
language:
source:
identifier: ISSN: 0999-193X ; E-ISSN: 1297-9686 ; DOI: 10.1186/1297-9686-39-1-73 ; PMCID: 2739435 ; PMID: 17212949
fulltext: fulltext
issn:
  • 0999-193X
  • 0999193X
  • 1297-9686
  • 12979686
url: Link


@attributes
ID1498880301
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid2739435
sourceidpubmed_central
recordidTN_pubmed_central2739435
sourceformatXML
sourcesystemOther
pqid68417556
display
typearticle
titleAssociations of myostatin gene polymorphisms with performance and mortality traits in broiler chickens
creatorYe, Xianghai ; Brown, Stewart R ; Nones, Kátia ; Coutinho, Luiz L ; Dekkers, Jack Cm ; Lamont, Susan J
ispartofGenetics, Selection, Evolution : GSE, 2007, Vol.39(1), p.73-89
identifier
subjectResearch ; Myostatin ; Snp ; Growth ; Mortality ; Broiler Chicken
descriptionMyostatin is a negative regulator of skeletal muscle growth. We evaluated effects of myostatin polymorphisms in three elite commercial broiler chicken lines on mortality, growth, feed conversion efficiency, ultrasound breast depth, breast percentage, eviscerated carcass weight, leg defects, blood oxygen level, and hen antibody titer to infectious bursal disease virus vaccine. Progeny mean data adjusted for fixed and mate effects and DNA from 100 sires per line were used. Single nucleotide polymorphisms (SNPs) of the myostatin gene segregating in these lines were identified by designing specific primers, amplifying individual DNA in each line by polymerase chain reaction, cloning, sequencing and aligning the corresponding products. Individual sires were genotyped for five identified SNPs which contributed to eight haplotypes. Frequencies of SNP alleles and haplotypes differed between lines. Using the allele substitution effect model, the myostatin SNPs were found to have significant ( P < 0.031) associations with growth, mortality, blood oxygen and hen antibody titer to infectious bursal disease virus vaccine, although the associations were not often consistent across lines. These results suggest that the myostatin gene has pleiotropic effects on broiler performance.
source
version8
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
search
creatorcontrib
0Ye, Xianghai
1Brown, Stewart R
2Nones, Kátia
3Coutinho, Luiz L
4Dekkers, Jack CM
5Lamont, Susan J
titleAssociations of myostatin gene polymorphisms with performance and mortality traits in broiler chickens
descriptionMyostatin is a negative regulator of skeletal muscle growth. We evaluated effects of myostatin polymorphisms in three elite commercial broiler chicken lines on mortality, growth, feed conversion efficiency, ultrasound breast depth, breast percentage, eviscerated carcass weight, leg defects, blood oxygen level, and hen antibody titer to infectious bursal disease virus vaccine. Progeny mean data adjusted for fixed and mate effects and DNA from 100 sires per line were used. Single nucleotide polymorphisms (SNPs) of the myostatin gene segregating in these lines were identified by designing specific primers, amplifying individual DNA in each line by polymerase chain reaction, cloning, sequencing and aligning the corresponding products. Individual sires were genotyped for five identified SNPs which contributed to eight haplotypes. Frequencies of SNP alleles and haplotypes differed between lines. Using the allele substitution effect model, the myostatin SNPs were found to have significant ( P < 0.031) associations with growth, mortality, blood oxygen and hen antibody titer to infectious bursal disease virus vaccine, although the associations were not often consistent across lines. These results suggest that the myostatin gene has pleiotropic effects on broiler performance.
subject
0Research
1myostatin
2SNP
3growth
4mortality
5broiler chicken
general
017212949
12739435
210.1186/1297-9686-39-1-73
3PMC (PubMed Central)
sourceidpubmed_central
recordidpubmed_central2739435
issn
00999-193X
10999193X
21297-9686
312979686
rsrctypearticle
creationdate2007
addtitleGenetics, Selection, Evolution : GSE
searchscopepubmed_central
scopepubmed_central
lsr30VSR-Enriched:[pages, pqid]
sort
titleAssociations of myostatin gene polymorphisms with performance and mortality traits in broiler chickens
authorYe, Xianghai ; Brown, Stewart R ; Nones, Kátia ; Coutinho, Luiz L ; Dekkers, Jack Cm ; Lamont, Susan J
creationdate20070111
facets
frbrgroupid381307135361138015
frbrtype5
creationdate2007
topic
0Research
1Myostatin
2Snp
3Growth
4Mortality
5Broiler Chicken
collectionPMC (PubMed Central)
prefilterarticles
rsrctypearticles
creatorcontrib
0Ye, Xianghai
1Brown, Stewart R
2Nones, Kátia
3Coutinho, Luiz L
4Dekkers, Jack CM
5Lamont, Susan J
jtitleGenetics, Selection, Evolution : Gse
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Ye
1Brown
2Nones
3Coutinho
4Dekkers
5Lamont
aufirst
0Xianghai
1Stewart R
2Kátia
3Luiz L
4Jack CM
5Susan J
au
0Ye, Xianghai
1Brown, Stewart R
2Nones, Kátia
3Coutinho, Luiz L
4Dekkers, Jack CM
5Lamont, Susan J
atitleAssociations of myostatin gene polymorphisms with performance and mortality traits in broiler chickens
jtitleGenetics, Selection, Evolution : GSE
risdate20070111
volume39
issue1
spage73
epage89
issn0999-193X
eissn1297-9686
formatjournal
genrearticle
ristypeJOUR
abstractMyostatin is a negative regulator of skeletal muscle growth. We evaluated effects of myostatin polymorphisms in three elite commercial broiler chicken lines on mortality, growth, feed conversion efficiency, ultrasound breast depth, breast percentage, eviscerated carcass weight, leg defects, blood oxygen level, and hen antibody titer to infectious bursal disease virus vaccine. Progeny mean data adjusted for fixed and mate effects and DNA from 100 sires per line were used. Single nucleotide polymorphisms (SNPs) of the myostatin gene segregating in these lines were identified by designing specific primers, amplifying individual DNA in each line by polymerase chain reaction, cloning, sequencing and aligning the corresponding products. Individual sires were genotyped for five identified SNPs which contributed to eight haplotypes. Frequencies of SNP alleles and haplotypes differed between lines. Using the allele substitution effect model, the myostatin SNPs were found to have significant ( P < 0.031) associations with growth, mortality, blood oxygen and hen antibody titer to infectious bursal disease virus vaccine, although the associations were not often consistent across lines. These results suggest that the myostatin gene has pleiotropic effects on broiler performance.
pubBioMed Central
doi10.1186/1297-9686-39-1-73
pmid17212949
pages73-89
oafree_for_read
date2007-01-11