schliessen

Filtern

 

Bibliotheken

Early-Stage Psychotherapy Produces Elevated Frontal White Matter Integrity in Adult Major Depressive Disorder

Background Psychotherapy has demonstrated comparable efficacy to antidepressant medication in the treatment of major depressive disorder. Metabolic alterations in the MDD state and in response to treatment have been detected by functional imaging methods, but the underlying white matter microstructu... Full description

Journal Title: PLoS ONE 2013, Vol.8(4)
Main Author: Wang, Tao
Other Authors: Huang, Xiaolan , Huang, Peiyu , Li, Dan , Lv, Fajin , Zhang, Yong , Zhou, Linke , Yang, Deyu , Xie, Peng
Format: Electronic Article Electronic Article
Language:
Subjects:
ID: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0063081 ; PMCID: 3640008 ; PMID: 23646178
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: pubmed_central3640008
title: Early-Stage Psychotherapy Produces Elevated Frontal White Matter Integrity in Adult Major Depressive Disorder
format: Article
creator:
  • Wang, Tao
  • Huang, Xiaolan
  • Huang, Peiyu
  • Li, Dan
  • Lv, Fajin
  • Zhang, Yong
  • Zhou, Linke
  • Yang, Deyu
  • Xie, Peng
subjects:
  • Research Article
  • Biology
  • Medicine
  • Social And Behavioral Sciences
ispartof: PLoS ONE, 2013, Vol.8(4)
description: Background Psychotherapy has demonstrated comparable efficacy to antidepressant medication in the treatment of major depressive disorder. Metabolic alterations in the MDD state and in response to treatment have been detected by functional imaging methods, but the underlying white matter microstructural changes remain unknown. The goal of this study is to apply diffusion tensor imaging techniques to investigate psychotherapy-specific responses in the white matter. Methods Twenty-one of forty-five outpatients diagnosed with major depression underwent diffusion tensor imaging before and after a four-week course of guided imagery psychotherapy. We compared fractional anisotropy in depressed patients (n = 21) with healthy controls (n = 22), and before-after treatment, using whole brain voxel-wise analysis. Results Post-treatment, depressed subjects showed a significant reduction in the 17-item Hamilton Depression Rating Scale. As compared to healthy controls, depressed subjects demonstrated significantly increased fractional anisotropy in the right thalamus. Psychopathological changes did not recover post-treatment, but a novel region of increased fractional anisotropy was discovered in the frontal lobe. Conclusions At an early stage of psychotherapy, higher fractional anisotropy was detected in the frontal emotional regulation-associated region. This finding reveals that psychotherapy may induce white matter changes in the frontal lobe. This remodeling of frontal connections within mood regulation networks positively contributes to the “top-down” mechanism of psychotherapy.
language:
source:
identifier: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0063081 ; PMCID: 3640008 ; PMID: 23646178
fulltext: fulltext
issn:
  • 1932-6203
  • 19326203
url: Link


@attributes
ID675019098
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid3640008
sourceidpubmed_central
recordidTN_pubmed_central3640008
sourceformatXML
sourcesystemPC
pqid1348122819
galeid477941364
display
typearticle
titleEarly-Stage Psychotherapy Produces Elevated Frontal White Matter Integrity in Adult Major Depressive Disorder
creatorWang, Tao ; Huang, Xiaolan ; Huang, Peiyu ; Li, Dan ; Lv, Fajin ; Zhang, Yong ; Zhou, Linke ; Yang, Deyu ; Xie, Peng
contributorHuang, Hao (editor)
ispartofPLoS ONE, 2013, Vol.8(4)
identifier
subjectResearch Article ; Biology ; Medicine ; Social And Behavioral Sciences
descriptionBackground Psychotherapy has demonstrated comparable efficacy to antidepressant medication in the treatment of major depressive disorder. Metabolic alterations in the MDD state and in response to treatment have been detected by functional imaging methods, but the underlying white matter microstructural changes remain unknown. The goal of this study is to apply diffusion tensor imaging techniques to investigate psychotherapy-specific responses in the white matter. Methods Twenty-one of forty-five outpatients diagnosed with major depression underwent diffusion tensor imaging before and after a four-week course of guided imagery psychotherapy. We compared fractional anisotropy in depressed patients (n = 21) with healthy controls (n = 22), and before-after treatment, using whole brain voxel-wise analysis. Results Post-treatment, depressed subjects showed a significant reduction in the 17-item Hamilton Depression Rating Scale. As compared to healthy controls, depressed subjects demonstrated significantly increased fractional anisotropy in the right thalamus. Psychopathological changes did not recover post-treatment, but a novel region of increased fractional anisotropy was discovered in the frontal lobe. Conclusions At an early stage of psychotherapy, higher fractional anisotropy was detected in the frontal emotional regulation-associated region. This finding reveals that psychotherapy may induce white matter changes in the frontal lobe. This remodeling of frontal connections within mood regulation networks positively contributes to the “top-down” mechanism of psychotherapy.
source
version8
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
search
creatorcontrib
0Wang, Tao
1Huang, Xiaolan
2Huang, Peiyu
3Li, Dan
4Lv, Fajin
5Zhang, Yong
6Zhou, Linke
7Yang, Deyu
8Xie, Peng
9Huang, Hao
titleEarly-Stage Psychotherapy Produces Elevated Frontal White Matter Integrity in Adult Major Depressive Disorder
descriptionBackground Psychotherapy has demonstrated comparable efficacy to antidepressant medication in the treatment of major depressive disorder. Metabolic alterations in the MDD state and in response to treatment have been detected by functional imaging methods, but the underlying white matter microstructural changes remain unknown. The goal of this study is to apply diffusion tensor imaging techniques to investigate psychotherapy-specific responses in the white matter. Methods Twenty-one of forty-five outpatients diagnosed with major depression underwent diffusion tensor imaging before and after a four-week course of guided imagery psychotherapy. We compared fractional anisotropy in depressed patients (n = 21) with healthy controls (n = 22), and before-after treatment, using whole brain voxel-wise analysis. Results Post-treatment, depressed subjects showed a significant reduction in the 17-item Hamilton Depression Rating Scale. As compared to healthy controls, depressed subjects demonstrated significantly increased fractional anisotropy in the right thalamus. Psychopathological changes did not recover post-treatment, but a novel region of increased fractional anisotropy was discovered in the frontal lobe. Conclusions At an early stage of psychotherapy, higher fractional anisotropy was detected in the frontal emotional regulation-associated region. This finding reveals that psychotherapy may induce white matter changes in the frontal lobe. This remodeling of frontal connections within mood regulation networks positively contributes to the “top-down” mechanism of psychotherapy.
subject
0Research Article
1Biology
2Medicine
3Social and Behavioral Sciences
general
023646178
13640008
210.1371/journal.pone.0063081
3PMC (PubMed Central)
sourceidpubmed_central
recordidpubmed_central3640008
issn
01932-6203
119326203
rsrctypearticle
creationdate2013
addtitlePLoS ONE
searchscopepubmed_central
scopepubmed_central
lsr30VSR-Enriched:[galeid, pages, pqid]
sort
titleEarly-Stage Psychotherapy Produces Elevated Frontal White Matter Integrity in Adult Major Depressive Disorder
authorWang, Tao ; Huang, Xiaolan ; Huang, Peiyu ; Li, Dan ; Lv, Fajin ; Zhang, Yong ; Zhou, Linke ; Yang, Deyu ; Xie, Peng
creationdate20130430
facets
frbrgroupid2673840225004049218
frbrtype5
newrecords20180328
creationdate2013
topic
0Research Article
1Biology
2Medicine
3Social And Behavioral Sciences
collectionPMC (PubMed Central)
prefilterarticles
rsrctypearticles
creatorcontrib
0Wang, Tao
1Huang, Xiaolan
2Huang, Peiyu
3Li, Dan
4Lv, Fajin
5Zhang, Yong
6Zhou, Linke
7Yang, Deyu
8Xie, Peng
9Huang, Hao
jtitlePlos One
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Wang
1Huang
2Li
3Lv
4Zhang
5Zhou
6Yang
7Xie
aufirst
0Tao
1Xiaolan
2Peiyu
3Dan
4Fajin
5Yong
6Linke
7Deyu
8Peng
9Hao
au
0Wang, Tao
1Huang, Xiaolan
2Huang, Peiyu
3Li, Dan
4Lv, Fajin
5Zhang, Yong
6Zhou, Linke
7Yang, Deyu
8Xie, Peng
9Huang, Hao
atitleEarly-Stage Psychotherapy Produces Elevated Frontal White Matter Integrity in Adult Major Depressive Disorder
jtitlePLoS ONE
risdate20130430
volume8
issue4
eissn1932-6203
formatjournal
genrearticle
ristypeJOUR
abstractBackground Psychotherapy has demonstrated comparable efficacy to antidepressant medication in the treatment of major depressive disorder. Metabolic alterations in the MDD state and in response to treatment have been detected by functional imaging methods, but the underlying white matter microstructural changes remain unknown. The goal of this study is to apply diffusion tensor imaging techniques to investigate psychotherapy-specific responses in the white matter. Methods Twenty-one of forty-five outpatients diagnosed with major depression underwent diffusion tensor imaging before and after a four-week course of guided imagery psychotherapy. We compared fractional anisotropy in depressed patients (n = 21) with healthy controls (n = 22), and before-after treatment, using whole brain voxel-wise analysis. Results Post-treatment, depressed subjects showed a significant reduction in the 17-item Hamilton Depression Rating Scale. As compared to healthy controls, depressed subjects demonstrated significantly increased fractional anisotropy in the right thalamus. Psychopathological changes did not recover post-treatment, but a novel region of increased fractional anisotropy was discovered in the frontal lobe. Conclusions At an early stage of psychotherapy, higher fractional anisotropy was detected in the frontal emotional regulation-associated region. This finding reveals that psychotherapy may induce white matter changes in the frontal lobe. This remodeling of frontal connections within mood regulation networks positively contributes to the “top-down” mechanism of psychotherapy.
pubPublic Library of Science
doi10.1371/journal.pone.0063081
pmid23646178
pagese63081
oafree_for_read
date2013-04-30