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Inhibition of Propofol Anesthesia on Functional Connectivity between LFPs in PFC during Rat Working Memory Task

Working memory (WM) refers to the temporary storage and manipulation of information necessary for performance of complex cognitive tasks. There is a growing interest in whether and how propofol anesthesia inhibits WM function. The aim of this study is to investigate the possible inhibition mechanism... Full description

Journal Title: PLoS ONE 2013, Vol.8(12)
Main Author: Xu, Xinyu
Other Authors: Tian, Yu , Li, Shuangyan , Li, Yize , Wang, Guolin , Tian, Xin
Format: Electronic Article Electronic Article
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ID: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0083653 ; PMCID: 3873953 ; PMID: 24386243
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title: Inhibition of Propofol Anesthesia on Functional Connectivity between LFPs in PFC during Rat Working Memory Task
format: Article
creator:
  • Xu, Xinyu
  • Tian, Yu
  • Li, Shuangyan
  • Li, Yize
  • Wang, Guolin
  • Tian, Xin
subjects:
  • Research Article
  • Biology
  • Engineering
  • Medicine
ispartof: PLoS ONE, 2013, Vol.8(12)
description: Working memory (WM) refers to the temporary storage and manipulation of information necessary for performance of complex cognitive tasks. There is a growing interest in whether and how propofol anesthesia inhibits WM function. The aim of this study is to investigate the possible inhibition mechanism of propofol anesthesia based on the functional connections of multi-local field potentials (LFPs) and behavior during WM tasks. Adult SD rats were randomly divided into 3 groups: pro group (0.5 mg·kg −1 ·min −1 ,2 h), PRO group (0.9 mg·kg −1 ·min −1 , 2 h) and control group. The experimental data were 16-channel LFPs obtained at prefrontal cortex with implanted microelectrode array in SD rats during WM tasks in Y-maze at 24, 48, 72, 96, 120 hours (day 1-day 5) after propofol anesthesia, and the behavior results of WM were recoded at the same time. Directed transfer function (DTF) method was applied to analyze the connections among LFPs directly. Furthermore, the causal networks were identified by DTF. The clustering coefficient ( C ), network density ( D ) and global efficiency ( E global ) were selected to describe the functional connectivity quantitatively. The results show that: comparing with the control group, the LFPs functional connectivity in pro group were no significantly difference ( p >0.05); the connectivity in PRO group were significantly decreased ( p
language:
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identifier: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0083653 ; PMCID: 3873953 ; PMID: 24386243
fulltext: fulltext
issn:
  • 1932-6203
  • 19326203
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titleInhibition of Propofol Anesthesia on Functional Connectivity between LFPs in PFC during Rat Working Memory Task
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descriptionWorking memory (WM) refers to the temporary storage and manipulation of information necessary for performance of complex cognitive tasks. There is a growing interest in whether and how propofol anesthesia inhibits WM function. The aim of this study is to investigate the possible inhibition mechanism of propofol anesthesia based on the functional connections of multi-local field potentials (LFPs) and behavior during WM tasks. Adult SD rats were randomly divided into 3 groups: pro group (0.5 mg·kg −1 ·min −1 ,2 h), PRO group (0.9 mg·kg −1 ·min −1 , 2 h) and control group. The experimental data were 16-channel LFPs obtained at prefrontal cortex with implanted microelectrode array in SD rats during WM tasks in Y-maze at 24, 48, 72, 96, 120 hours (day 1-day 5) after propofol anesthesia, and the behavior results of WM were recoded at the same time. Directed transfer function (DTF) method was applied to analyze the connections among LFPs directly. Furthermore, the causal networks were identified by DTF. The clustering coefficient ( C ), network density ( D ) and global efficiency ( E global ) were selected to describe the functional connectivity quantitatively. The results show that: comparing with the control group, the LFPs functional connectivity in pro group were no significantly difference ( p >0.05); the connectivity in PRO group were significantly decreased ( p <0.05 at 24 hours, p <0.05 at 48 hours), while no significant difference at 72, 96 and 120 hours for rats ( p >0.05), which were consistent with the behavior results. These findings could lead to improved understanding the mechanism of inhibition of anesthesia on WM functions from the view of connections among LFPs.
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abstractWorking memory (WM) refers to the temporary storage and manipulation of information necessary for performance of complex cognitive tasks. There is a growing interest in whether and how propofol anesthesia inhibits WM function. The aim of this study is to investigate the possible inhibition mechanism of propofol anesthesia based on the functional connections of multi-local field potentials (LFPs) and behavior during WM tasks. Adult SD rats were randomly divided into 3 groups: pro group (0.5 mg·kg −1 ·min −1 ,2 h), PRO group (0.9 mg·kg −1 ·min −1 , 2 h) and control group. The experimental data were 16-channel LFPs obtained at prefrontal cortex with implanted microelectrode array in SD rats during WM tasks in Y-maze at 24, 48, 72, 96, 120 hours (day 1-day 5) after propofol anesthesia, and the behavior results of WM were recoded at the same time. Directed transfer function (DTF) method was applied to analyze the connections among LFPs directly. Furthermore, the causal networks were identified by DTF. The clustering coefficient ( C ), network density ( D ) and global efficiency ( E global ) were selected to describe the functional connectivity quantitatively. The results show that: comparing with the control group, the LFPs functional connectivity in pro group were no significantly difference ( p >0.05); the connectivity in PRO group were significantly decreased ( p <0.05 at 24 hours, p <0.05 at 48 hours), while no significant difference at 72, 96 and 120 hours for rats ( p >0.05), which were consistent with the behavior results. These findings could lead to improved understanding the mechanism of inhibition of anesthesia on WM functions from the view of connections among LFPs.
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date2013-12-27