schliessen

Filtern

 

Bibliotheken

MicroRNA-29 Fine-tunes the Expression of Key FOXA2-Activated Lipid Metabolism Genes and Is Dysregulated in Animal Models of Insulin Resistance and Diabetes

MicroRNAs (miRNAs) have emerged as biomarkers of metabolic status, etiological factors in complex disease, and promising drug targets. Recent reports suggest that miRNAs are critical regulators of pathways underlying the pathophysiology of type 2 diabetes. In this study, we demonstrate by deep seque... Full description

Journal Title: Diabetes 2014, Vol.63(9), p.3141-3148
Main Author: Kurtz, C. Lisa
Other Authors: Peck, Bailey C.E , Fannin, Emily E , Beysen, Carine , Miao, Ji , Landstreet, Stuart R , Ding, Shengli , Turaga, Vandana , Lund, P. Kay , Turner, Scott , Biddinger, Sudha B , Vickers, Kasey C , Sethupathy, Praveen
Format: Electronic Article Electronic Article
Language:
Subjects:
ID: ISSN: 0012-1797 ; E-ISSN: 1939-327X ; DOI: 10.2337/db13-1015 ; PMCID: 4141370 ; PMID: 24722248
Link: 3141.pdf
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: pubmed_central4141370
title: MicroRNA-29 Fine-tunes the Expression of Key FOXA2-Activated Lipid Metabolism Genes and Is Dysregulated in Animal Models of Insulin Resistance and Diabetes
format: Article
creator:
  • Kurtz, C. Lisa
  • Peck, Bailey C.E
  • Fannin, Emily E
  • Beysen, Carine
  • Miao, Ji
  • Landstreet, Stuart R
  • Ding, Shengli
  • Turaga, Vandana
  • Lund, P. Kay
  • Turner, Scott
  • Biddinger, Sudha B
  • Vickers, Kasey C
  • Sethupathy, Praveen
subjects:
  • Genetics/Genomes/Proteomics/Metabolomics
ispartof: Diabetes, 2014, Vol.63(9), p.3141-3148
description: MicroRNAs (miRNAs) have emerged as biomarkers of metabolic status, etiological factors in complex disease, and promising drug targets. Recent reports suggest that miRNAs are critical regulators of pathways underlying the pathophysiology of type 2 diabetes. In this study, we demonstrate by deep sequencing and real-time quantitative PCR that hepatic levels of Foxa2 mRNA and miR-29 are elevated in a mouse model of diet-induced insulin resistance. We also show that Foxa2 and miR-29 are significantly upregulated in the livers of Zucker diabetic fatty ( fa/fa ) rats and that the levels of both returned to normal upon treatment with the insulin-sensitizing agent pioglitazone. We present evidence that miR-29 expression in human hepatoma cells is controlled in part by FOXA2, which is known to play a critical role in hepatic energy homeostasis. Moreover, we demonstrate that miR-29 fine-tunes FOXA2-mediated activation of key lipid metabolism genes, including PPARGC1A , HMGCS2 , and ABHD5 . These results suggest that miR-29 is an important regulatory factor in normal metabolism and may represent a novel therapeutic target in type 2 diabetes and related metabolic syndromes.
language:
source:
identifier: ISSN: 0012-1797 ; E-ISSN: 1939-327X ; DOI: 10.2337/db13-1015 ; PMCID: 4141370 ; PMID: 24722248
fulltext: fulltext
issn:
  • 0012-1797
  • 00121797
  • 1939-327X
  • 1939327X
url: Link


@attributes
ID643986798
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid4141370
sourceidpubmed_central
recordidTN_pubmed_central4141370
sourceformatXML
sourcesystemPC
pqid1555619037
galeid385575646
display
typearticle
titleMicroRNA-29 Fine-tunes the Expression of Key FOXA2-Activated Lipid Metabolism Genes and Is Dysregulated in Animal Models of Insulin Resistance and Diabetes
creatorKurtz, C. Lisa ; Peck, Bailey C.E ; Fannin, Emily E ; Beysen, Carine ; Miao, Ji ; Landstreet, Stuart R ; Ding, Shengli ; Turaga, Vandana ; Lund, P. Kay ; Turner, Scott ; Biddinger, Sudha B ; Vickers, Kasey C ; Sethupathy, Praveen
ispartofDiabetes, 2014, Vol.63(9), p.3141-3148
identifier
subjectGenetics/Genomes/Proteomics/Metabolomics
descriptionMicroRNAs (miRNAs) have emerged as biomarkers of metabolic status, etiological factors in complex disease, and promising drug targets. Recent reports suggest that miRNAs are critical regulators of pathways underlying the pathophysiology of type 2 diabetes. In this study, we demonstrate by deep sequencing and real-time quantitative PCR that hepatic levels of Foxa2 mRNA and miR-29 are elevated in a mouse model of diet-induced insulin resistance. We also show that Foxa2 and miR-29 are significantly upregulated in the livers of Zucker diabetic fatty ( fa/fa ) rats and that the levels of both returned to normal upon treatment with the insulin-sensitizing agent pioglitazone. We present evidence that miR-29 expression in human hepatoma cells is controlled in part by FOXA2, which is known to play a critical role in hepatic energy homeostasis. Moreover, we demonstrate that miR-29 fine-tunes FOXA2-mediated activation of key lipid metabolism genes, including PPARGC1A , HMGCS2 , and ABHD5 . These results suggest that miR-29 is an important regulatory factor in normal metabolism and may represent a novel therapeutic target in type 2 diabetes and related metabolic syndromes.
source
version7
lds50peer_reviewed
links
openurl$$Topenurl_article
backlink$$U3141.pdf$$EView_source_record
openurlfulltext$$Topenurlfull_article
search
creatorcontrib
0Kurtz, C. Lisa
1Peck, Bailey C.E
2Fannin, Emily E
3Beysen, Carine
4Miao, Ji
5Landstreet, Stuart R
6Ding, Shengli
7Turaga, Vandana
8Lund, P. Kay
9Turner, Scott
10Biddinger, Sudha B
11Vickers, Kasey C
12Sethupathy, Praveen
titleMicroRNA-29 Fine-tunes the Expression of Key FOXA2-Activated Lipid Metabolism Genes and Is Dysregulated in Animal Models of Insulin Resistance and Diabetes
descriptionMicroRNAs (miRNAs) have emerged as biomarkers of metabolic status, etiological factors in complex disease, and promising drug targets. Recent reports suggest that miRNAs are critical regulators of pathways underlying the pathophysiology of type 2 diabetes. In this study, we demonstrate by deep sequencing and real-time quantitative PCR that hepatic levels of Foxa2 mRNA and miR-29 are elevated in a mouse model of diet-induced insulin resistance. We also show that Foxa2 and miR-29 are significantly upregulated in the livers of Zucker diabetic fatty ( fa/fa ) rats and that the levels of both returned to normal upon treatment with the insulin-sensitizing agent pioglitazone. We present evidence that miR-29 expression in human hepatoma cells is controlled in part by FOXA2, which is known to play a critical role in hepatic energy homeostasis. Moreover, we demonstrate that miR-29 fine-tunes FOXA2-mediated activation of key lipid metabolism genes, including PPARGC1A , HMGCS2 , and ABHD5 . These results suggest that miR-29 is an important regulatory factor in normal metabolism and may represent a novel therapeutic target in type 2 diabetes and related metabolic syndromes.
subjectGenetics/Genomes/Proteomics/Metabolomics
general
024722248
14141370
210.2337/db13-1015
3PMC (PubMed Central)
sourceidpubmed_central
recordidpubmed_central4141370
issn
00012-1797
100121797
21939-327X
31939327X
rsrctypearticle
creationdate2014
addtitleDiabetes
searchscopepubmed_central
scopepubmed_central
lsr30VSR-Enriched:[galeid, pqid, pages]
sort
titleMicroRNA-29 Fine-tunes the Expression of Key FOXA2-Activated Lipid Metabolism Genes and Is Dysregulated in Animal Models of Insulin Resistance and Diabetes
authorKurtz, C. Lisa ; Peck, Bailey C.E ; Fannin, Emily E ; Beysen, Carine ; Miao, Ji ; Landstreet, Stuart R ; Ding, Shengli ; Turaga, Vandana ; Lund, P. Kay ; Turner, Scott ; Biddinger, Sudha B ; Vickers, Kasey C ; Sethupathy, Praveen
creationdate20140900
facets
frbrgroupid8094659699630932874
frbrtype5
creationdate2014
topicGenetics/Genomes/Proteomics/Metabolomics
collectionPMC (PubMed Central)
prefilterarticles
rsrctypearticles
creatorcontrib
0Kurtz, C. Lisa
1Peck, Bailey C.E.
2Fannin, Emily E.
3Beysen, Carine
4Miao, Ji
5Landstreet, Stuart R.
6Ding, Shengli
7Turaga, Vandana
8Lund, P. Kay
9Turner, Scott
10Biddinger, Sudha B.
11Vickers, Kasey C.
12Sethupathy, Praveen
jtitleDiabetes
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Kurtz
1Peck
2Fannin
3Beysen
4Miao
5Landstreet
6Ding
7Turaga
8Lund
9Turner
10Biddinger
11Vickers
12Sethupathy
aufirst
0C. Lisa
1Bailey C.E.
2Emily E.
3Carine
4Ji
5Stuart R.
6Shengli
7Vandana
8P. Kay
9Scott
10Sudha B.
11Kasey C.
12Praveen
au
0Kurtz, C. Lisa
1Peck, Bailey C.E.
2Fannin, Emily E.
3Beysen, Carine
4Miao, Ji
5Landstreet, Stuart R.
6Ding, Shengli
7Turaga, Vandana
8Lund, P. Kay
9Turner, Scott
10Biddinger, Sudha B.
11Vickers, Kasey C.
12Sethupathy, Praveen
atitleMicroRNA-29 Fine-tunes the Expression of Key FOXA2-Activated Lipid Metabolism Genes and Is Dysregulated in Animal Models of Insulin Resistance and Diabetes
jtitleDiabetes
risdate20140900
volume63
issue9
spage3141
epage3148
issn0012-1797
eissn1939-327X
formatjournal
genrearticle
ristypeJOUR
abstractMicroRNAs (miRNAs) have emerged as biomarkers of metabolic status, etiological factors in complex disease, and promising drug targets. Recent reports suggest that miRNAs are critical regulators of pathways underlying the pathophysiology of type 2 diabetes. In this study, we demonstrate by deep sequencing and real-time quantitative PCR that hepatic levels of Foxa2 mRNA and miR-29 are elevated in a mouse model of diet-induced insulin resistance. We also show that Foxa2 and miR-29 are significantly upregulated in the livers of Zucker diabetic fatty ( fa/fa ) rats and that the levels of both returned to normal upon treatment with the insulin-sensitizing agent pioglitazone. We present evidence that miR-29 expression in human hepatoma cells is controlled in part by FOXA2, which is known to play a critical role in hepatic energy homeostasis. Moreover, we demonstrate that miR-29 fine-tunes FOXA2-mediated activation of key lipid metabolism genes, including PPARGC1A , HMGCS2 , and ABHD5 . These results suggest that miR-29 is an important regulatory factor in normal metabolism and may represent a novel therapeutic target in type 2 diabetes and related metabolic syndromes.
pubAmerican Diabetes Association
doi10.2337/db13-1015
pmid24722248
pages3141-318
oafree_for_read
date2014-09-00