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Glucocorticoid Induces Incoordination between Glutamatergic and GABAergic Neurons in the Amygdala

Background Stressful life leads to mood disorders. Chronic mild stress is presumably major etiology for depression, and acute severe stress leads to anxiety. These stressful situations may impair hypothalamus-pituitary-adrenal axis and in turn induce synapse dysfunction. However, it remains elusive... Full description

Journal Title: PLoS ONE 2016, Vol.11(11)
Main Author: Wang, Guang-Yan
Other Authors: Zhu, Zhao-Ming , Cui, Shan , Wang, Jin-Hui
Format: Electronic Article Electronic Article
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ID: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0166535 ; PMCID: 5115758 ; PMID: 27861545
Link: pone.0166535.pdf
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recordid: pubmed_central5115758
title: Glucocorticoid Induces Incoordination between Glutamatergic and GABAergic Neurons in the Amygdala
format: Article
creator:
  • Wang, Guang-Yan
  • Zhu, Zhao-Ming
  • Cui, Shan
  • Wang, Jin-Hui
subjects:
  • Research Article
  • Biology And Life Sciences
  • Biology And Life Sciences
  • Biology And Life Sciences
  • Medicine And Health Sciences
  • Biology And Life Sciences
  • Medicine And Health Sciences
  • Biology And Life Sciences
  • Medicine And Health Sciences
  • Biology And Life Sciences
  • Biology And Life Sciences
  • Biology And Life Sciences
  • Biology And Life Sciences
  • Biology And Life Sciences
  • Medicine And Health Sciences
  • Biology And Life Sciences
  • Social Sciences
  • Medicine And Health Sciences
  • Medicine And Health Sciences
  • Medicine And Health Sciences
ispartof: PLoS ONE, 2016, Vol.11(11)
description: Background Stressful life leads to mood disorders. Chronic mild stress is presumably major etiology for depression, and acute severe stress leads to anxiety. These stressful situations may impair hypothalamus-pituitary-adrenal axis and in turn induce synapse dysfunction. However, it remains elusive how the stress hormones mess up subcellular compartments and interactions between excitatory and inhibitory neurons, which we have investigated in mouse amygdala, a structure related to emotional states. Methods and Results Dexamethasone was chronically given by intraperitoneal injection once a day for one week or was acutely washed into the brain slices. The neuronal spikes and synaptic transmission were recorded by whole-cell patching in amygdala neurons of brain slices. The chronic or acute administration of dexamethasone downregulates glutamate release as well as upregulates GABA release and GABAergic neuron spiking. The chronic administration of dexamethasone also enhances the responsiveness of GABA receptors. Conclusion The upregulation of GABAergic neurons and the downregulation of glutamatergic neurons by glucocorticoid impair their balance in the amygdala, which leads to emotional disorders during stress.
language:
source:
identifier: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0166535 ; PMCID: 5115758 ; PMID: 27861545
fulltext: fulltext
issn:
  • 1932-6203
  • 19326203
url: Link


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titleGlucocorticoid Induces Incoordination between Glutamatergic and GABAergic Neurons in the Amygdala
creatorWang, Guang-Yan ; Zhu, Zhao-Ming ; Cui, Shan ; Wang, Jin-Hui
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descriptionBackground Stressful life leads to mood disorders. Chronic mild stress is presumably major etiology for depression, and acute severe stress leads to anxiety. These stressful situations may impair hypothalamus-pituitary-adrenal axis and in turn induce synapse dysfunction. However, it remains elusive how the stress hormones mess up subcellular compartments and interactions between excitatory and inhibitory neurons, which we have investigated in mouse amygdala, a structure related to emotional states. Methods and Results Dexamethasone was chronically given by intraperitoneal injection once a day for one week or was acutely washed into the brain slices. The neuronal spikes and synaptic transmission were recorded by whole-cell patching in amygdala neurons of brain slices. The chronic or acute administration of dexamethasone downregulates glutamate release as well as upregulates GABA release and GABAergic neuron spiking. The chronic administration of dexamethasone also enhances the responsiveness of GABA receptors. Conclusion The upregulation of GABAergic neurons and the downregulation of glutamatergic neurons by glucocorticoid impair their balance in the amygdala, which leads to emotional disorders during stress.
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descriptionBackground Stressful life leads to mood disorders. Chronic mild stress is presumably major etiology for depression, and acute severe stress leads to anxiety. These stressful situations may impair hypothalamus-pituitary-adrenal axis and in turn induce synapse dysfunction. However, it remains elusive how the stress hormones mess up subcellular compartments and interactions between excitatory and inhibitory neurons, which we have investigated in mouse amygdala, a structure related to emotional states. Methods and Results Dexamethasone was chronically given by intraperitoneal injection once a day for one week or was acutely washed into the brain slices. The neuronal spikes and synaptic transmission were recorded by whole-cell patching in amygdala neurons of brain slices. The chronic or acute administration of dexamethasone downregulates glutamate release as well as upregulates GABA release and GABAergic neuron spiking. The chronic administration of dexamethasone also enhances the responsiveness of GABA receptors. Conclusion The upregulation of GABAergic neurons and the downregulation of glutamatergic neurons by glucocorticoid impair their balance in the amygdala, which leads to emotional disorders during stress.
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abstractBackground Stressful life leads to mood disorders. Chronic mild stress is presumably major etiology for depression, and acute severe stress leads to anxiety. These stressful situations may impair hypothalamus-pituitary-adrenal axis and in turn induce synapse dysfunction. However, it remains elusive how the stress hormones mess up subcellular compartments and interactions between excitatory and inhibitory neurons, which we have investigated in mouse amygdala, a structure related to emotional states. Methods and Results Dexamethasone was chronically given by intraperitoneal injection once a day for one week or was acutely washed into the brain slices. The neuronal spikes and synaptic transmission were recorded by whole-cell patching in amygdala neurons of brain slices. The chronic or acute administration of dexamethasone downregulates glutamate release as well as upregulates GABA release and GABAergic neuron spiking. The chronic administration of dexamethasone also enhances the responsiveness of GABA receptors. Conclusion The upregulation of GABAergic neurons and the downregulation of glutamatergic neurons by glucocorticoid impair their balance in the amygdala, which leads to emotional disorders during stress.
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date2016-11-18