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Differentially expressed genes in the head of the 2 nd instar pre-molting larvae of the nm2 mutant of the silkworm, Bombyx mori

Molting is an important physiological process in the larval stage of Bombyx mori and is controlled by various hormones and peptides. The silkworm mutant that exhibits the phenotype of non-molting in the 2 nd instar ( nm2 ) is incapable of molting in the 2 nd instar and dies after seven or more days.... Full description

Journal Title: PLoS ONE 2017, Vol.12(7)
Main Author: Wang, Pingyang
Other Authors: Bi, Simin , Wu, Fan , Xu, Pingzhen , Shen, Xingjia , Zhao, Qiaoling
Format: Electronic Article Electronic Article
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ID: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0180160 ; PMCID: 5519023 ; PMID: 28727825
Link: pone.0180160.pdf
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title: Differentially expressed genes in the head of the 2 nd instar pre-molting larvae of the nm2 mutant of the silkworm, Bombyx mori
format: Article
creator:
  • Wang, Pingyang
  • Bi, Simin
  • Wu, Fan
  • Xu, Pingzhen
  • Shen, Xingjia
  • Zhao, Qiaoling
subjects:
  • Research Article
  • Biology And Life Sciences
  • Biology And Life Sciences
  • Medicine And Health Sciences
  • Biology And Life Sciences
  • Biology And Life Sciences
  • Physical Sciences
  • Physical Sciences
  • Biology And Life Sciences
  • Medicine And Health Sciences
  • Biology And Life Sciences
  • Biology And Life Sciences
ispartof: PLoS ONE, 2017, Vol.12(7)
description: Molting is an important physiological process in the larval stage of Bombyx mori and is controlled by various hormones and peptides. The silkworm mutant that exhibits the phenotype of non-molting in the 2 nd instar ( nm2 ) is incapable of molting in the 2 nd instar and dies after seven or more days. The ecdysone titer in the nm2 mutant is lower than that in the wildtype, and the mutant can be rescued by feeding with 20E and cholesterol. The results of positional cloning indicated that structural alteration of BmCPG10 is responsible for the phenotype of the nm2 mutant. To explore the possible relationship between BmCPG10 and the ecdysone titer as well as the genes affected by BmCPG10 , digital gene expression (DGE) profile analysis was conducted in the nm2 mutant, with the wildtype strain C603 serving as the control. The results revealed 1727 differentially expressed genes, among which 651 genes were upregulated and 1076 were downregulated in nm2 . BLASTGO analysis showed...
language:
source:
identifier: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0180160 ; PMCID: 5519023 ; PMID: 28727825
fulltext: fulltext
issn:
  • 1932-6203
  • 19326203
url: Link


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titleDifferentially expressed genes in the head of the 2 nd instar pre-molting larvae of the nm2 mutant of the silkworm, Bombyx mori
creatorWang, Pingyang ; Bi, Simin ; Wu, Fan ; Xu, Pingzhen ; Shen, Xingjia ; Zhao, Qiaoling
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subjectResearch Article ; Biology And Life Sciences ; Biology And Life Sciences ; Medicine And Health Sciences ; Biology And Life Sciences ; Biology And Life Sciences ; Physical Sciences ; Physical Sciences ; Biology And Life Sciences ; Medicine And Health Sciences ; Biology And Life Sciences ; Biology And Life Sciences
descriptionMolting is an important physiological process in the larval stage of Bombyx mori and is controlled by various hormones and peptides. The silkworm mutant that exhibits the phenotype of non-molting in the 2 nd instar ( nm2 ) is incapable of molting in the 2 nd instar and dies after seven or more days. The ecdysone titer in the nm2 mutant is lower than that in the wildtype, and the mutant can be rescued by feeding with 20E and cholesterol. The results of positional cloning indicated that structural alteration of BmCPG10 is responsible for the phenotype of the nm2 mutant. To explore the possible relationship between BmCPG10 and the ecdysone titer as well as the genes affected by BmCPG10 , digital gene expression (DGE) profile analysis was conducted in the nm2 mutant, with the wildtype strain C603 serving as the control. The results revealed 1727 differentially expressed genes, among which 651 genes were upregulated and 1076 were downregulated in nm2 . BLASTGO analysis showed...
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titleDifferentially expressed genes in the head of the 2 nd instar pre-molting larvae of the nm2 mutant of the silkworm, Bombyx mori
descriptionMolting is an important physiological process in the larval stage of Bombyx mori and is controlled by various hormones and peptides. The silkworm mutant that exhibits the phenotype of non-molting in the 2 nd instar ( nm2 ) is incapable of molting in the 2 nd instar and dies after seven or more days. The ecdysone titer in the nm2 mutant is lower than that in the wildtype, and the mutant can be rescued by feeding with 20E and cholesterol. The results of positional cloning indicated that structural alteration of BmCPG10 is responsible for the phenotype of the nm2 mutant. To explore the possible relationship between BmCPG10 and the ecdysone titer as well as the genes affected by BmCPG10 , digital gene expression (DGE) profile analysis was conducted in the nm2 mutant, with the wildtype strain C603 serving as the control. The results revealed 1727 differentially expressed genes, among which 651 genes were upregulated and 1076 were downregulated in nm2 . BLASTGO analysis showed...
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abstractMolting is an important physiological process in the larval stage of Bombyx mori and is controlled by various hormones and peptides. The silkworm mutant that exhibits the phenotype of non-molting in the 2 nd instar ( nm2 ) is incapable of molting in the 2 nd instar and dies after seven or more days. The ecdysone titer in the nm2 mutant is lower than that in the wildtype, and the mutant can be rescued by feeding with 20E and cholesterol. The results of positional cloning indicated that structural alteration of BmCPG10 is responsible for the phenotype of the nm2 mutant. To explore the possible relationship between BmCPG10 and the ecdysone titer as well as the genes affected by BmCPG10 , digital gene expression (DGE) profile analysis was conducted in the nm2 mutant, with the wildtype strain C603 serving as the control. The results revealed 1727 differentially expressed genes, among which 651 genes were upregulated and 1076 were downregulated in nm2 . BLASTGO analysis showed...
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