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Efficient photoactivation of a Diels-Alderase ribozyme

Here we report the first example of a photoactivatable ribozyme which catalyzes a bimolecular reaction of two small organic molecules with multiple turnover, under control of a photo-cleavable protecting group by exploiting the structural significance of a single hydrogen bond.

Journal Title: Chemical Communications 2010, Vol.46(42), pp.7975-7977
Main Author: Nierth, Alexander
Other Authors: Singer, Marco , Jschke, Andres
Format: Electronic Article Electronic Article
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Subjects:
ID: ISSN: 1359-7345 ; E-ISSN: 1364-548X ; DOI: 10.1039/c0cc03162c
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recordid: rscc0cc03162c
title: Efficient photoactivation of a Diels-Alderase ribozyme
format: Article
creator:
  • Nierth, Alexander
  • Singer, Marco
  • Jschke, Andres
subjects:
  • Photochemistry
  • RNA, Catalytic -- Metabolism
ispartof: Chemical Communications, 2010, Vol.46(42), pp.7975-7977
description: Here we report the first example of a photoactivatable ribozyme which catalyzes a bimolecular reaction of two small organic molecules with multiple turnover, under control of a photo-cleavable protecting group by exploiting the structural significance of a single hydrogen bond.
language:
source:
identifier: ISSN: 1359-7345 ; E-ISSN: 1364-548X ; DOI: 10.1039/c0cc03162c
fulltext: fulltext
issn:
  • 1359-7345
  • 1364-548X
  • 1364548X
  • 13597345
url: Link


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descriptionHere we report the first example of a photoactivatable ribozyme which catalyzes a bimolecular reaction of two small organic molecules with multiple turnover, under control of a photo-cleavable protecting group by exploiting the structural significance of a single hydrogen bond.
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abstractHere we report the first example of a photoactivatable ribozyme which catalyzes a bimolecular reaction of two small organic molecules with multiple turnover, under control of a photo-cleavable protecting group by exploiting the structural significance of a single hydrogen bond.
doi10.1039/c0cc03162c
pages7975-7
date2010-10-19