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Fluorescent chemodosimeter for Cys/Hcy with a large absorption shift and imaging in living cells

A novel molecule T1 with efficient intramolecular charge transfer was designed as a fluorescent chemodosimeter for cysteine (Cys) and homocysteine (Hcy). Upon addition of Cys/Hcy, T1 exhibited greatly enhanced fluorescence intensity as well as a large absorption peak shift (70 nm), and can be used f... Full description

Journal Title: Organic & Biomolecular Chemistry 2011, Vol.9(4), pp.980-983
Main Author: Hu, Mingming
Other Authors: Fan, Jiangli , Li, Honglin , Song, Kedong , Wang, Song , Cheng, Guanghui , Peng, Xiaojun
Format: Electronic Article Electronic Article
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ID: ISSN: 1477-0520 ; E-ISSN: 1477-0539 ; DOI: 10.1039/c0ob00957a
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recordid: rscc0ob00957a
title: Fluorescent chemodosimeter for Cys/Hcy with a large absorption shift and imaging in living cells
format: Article
creator:
  • Hu, Mingming
  • Fan, Jiangli
  • Li, Honglin
  • Song, Kedong
  • Wang, Song
  • Cheng, Guanghui
  • Peng, Xiaojun
subjects:
  • Cysteine -- Chemistry
  • Fluorescent Dyes -- Chemistry
  • Homocysteine -- Chemistry
ispartof: Organic & Biomolecular Chemistry, 2011, Vol.9(4), pp.980-983
description: A novel molecule T1 with efficient intramolecular charge transfer was designed as a fluorescent chemodosimeter for cysteine (Cys) and homocysteine (Hcy). Upon addition of Cys/Hcy, T1 exhibited greatly enhanced fluorescence intensity as well as a large absorption peak shift (70 nm), and can be used for bioimaging of Cys/Hcy in living cells and detection in human plasma by visual color change. The detection mechanism was proved by 1 H NMR, mass spectrometry analysis and Gaussian calculations.
language:
source:
identifier: ISSN: 1477-0520 ; E-ISSN: 1477-0539 ; DOI: 10.1039/c0ob00957a
fulltext: no_fulltext
issn:
  • 1477-0520
  • 1477-0539
  • 14770539
  • 14770520
url: Link


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titleFluorescent chemodosimeter for Cys/Hcy with a large absorption shift and imaging in living cells
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descriptionA novel molecule T1 with efficient intramolecular charge transfer was designed as a fluorescent chemodosimeter for cysteine (Cys) and homocysteine (Hcy). Upon addition of Cys/Hcy, T1 exhibited greatly enhanced fluorescence intensity as well as a large absorption peak shift (70 nm), and can be used for bioimaging of Cys/Hcy in living cells and detection in human plasma by visual color change. The detection mechanism was proved by 1 H NMR, mass spectrometry analysis and Gaussian calculations.
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titleFluorescent chemodosimeter for Cys/Hcy with a large absorption shift and imaging in living cells
descriptionA novel molecule T1 with efficient intramolecular charge transfer was designed as a fluorescent chemodosimeter for cysteine (Cys) and homocysteine (Hcy). Upon addition of Cys/Hcy, T1 exhibited greatly enhanced fluorescence intensity as well as a large absorption peak shift (70 nm), and can be used for bioimaging of Cys/Hcy in living cells and detection in human plasma by visual color change. The detection mechanism was proved by 1 H NMR, mass spectrometry analysis and Gaussian calculations.
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abstractA novel molecule T1 with efficient intramolecular charge transfer was designed as a fluorescent chemodosimeter for cysteine (Cys) and homocysteine (Hcy). Upon addition of Cys/Hcy, T1 exhibited greatly enhanced fluorescence intensity as well as a large absorption peak shift (70 nm), and can be used for bioimaging of Cys/Hcy in living cells and detection in human plasma by visual color change. The detection mechanism was proved by 1 H NMR, mass spectrometry analysis and Gaussian calculations.
doi10.1039/c0ob00957a
pages980-983
date2011-02-02