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Site-selective DNA hydrolysis induced by a metal-free peptide nucleic acidcyclen conjugate

A metal-free artificial restriction DNA cutter which is composed of cyclen and classical peptide nucleic acid (PNA) was synthesized. Analysis of DNA cleavage products indicates the site-selective hydrolysis.

Journal Title: Chemical Communications 2011, Vol.47(39), pp.11059-11061
Main Author: Wang, Ming-qi
Other Authors: Liu, Jun-liang , Wang, Jing-yi , Zhang, Da-wei , Zhang, Ji , Streckenbach, Frank , Tang, Zhuo , Lin, Hong-hui , Liu, Yan , Zhao, Yu-fen , Yu, Xiao-qi
Format: Electronic Article Electronic Article
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ID: ISSN: 1359-7345 ; E-ISSN: 1364-548X ; DOI: 10.1039/c1cc14185f
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recordid: rscc1cc14185f
title: Site-selective DNA hydrolysis induced by a metal-free peptide nucleic acidcyclen conjugate
format: Article
creator:
  • Wang, Ming-qi
  • Liu, Jun-liang
  • Wang, Jing-yi
  • Zhang, Da-wei
  • Zhang, Ji
  • Streckenbach, Frank
  • Tang, Zhuo
  • Lin, Hong-hui
  • Liu, Yan
  • Zhao, Yu-fen
  • Yu, Xiao-qi
subjects:
  • Chemistry
ispartof: Chemical Communications, 2011, Vol.47(39), pp.11059-11061
description: A metal-free artificial restriction DNA cutter which is composed of cyclen and classical peptide nucleic acid (PNA) was synthesized. Analysis of DNA cleavage products indicates the site-selective hydrolysis.
language:
source:
identifier: ISSN: 1359-7345 ; E-ISSN: 1364-548X ; DOI: 10.1039/c1cc14185f
fulltext: fulltext
issn:
  • 1359-7345
  • 1364-548X
  • 1364548X
  • 13597345
url: Link


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abstractA metal-free artificial restriction DNA cutter which is composed of cyclen and classical peptide nucleic acid (PNA) was synthesized. Analysis of DNA cleavage products indicates the site-selective hydrolysis.
doi10.1039/c1cc14185f
pages11059-11061
date2011-09-27