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Antioxidant activity and oxidative stress protection of duck proteins hydrolysates in SK-N-SH cells

Studies have found that natural antioxidants, which are free-radical scavengers, can reduce the risk of diseases caused by free radicals. This work investigated the antioxidant properties of duck proteins hydrolysates. The free-radical scavenging function of CP-1 ( M r > 10 kDa), CP-2 (5 kDa < M r <... Full description

Journal Title: Food & Function 2013, Vol.4(3), pp.476-480
Main Author: Guo, Yuxing
Other Authors: Pan, Daodong , Wu, Zhen , Zhao, Chuanchuan , Cao, Jinxuan
Format: Electronic Article Electronic Article
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ID: ISSN: 2042-6496 ; E-ISSN: 2042-650X ; DOI: 10.1039/c2fo30264k
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recordid: rscc2fo30264k
title: Antioxidant activity and oxidative stress protection of duck proteins hydrolysates in SK-N-SH cells
format: Article
creator:
  • Guo, Yuxing
  • Pan, Daodong
  • Wu, Zhen
  • Zhao, Chuanchuan
  • Cao, Jinxuan
subjects:
  • Ultrafiltration
  • Risk Assessment
  • Filtration
  • Antioxidants
  • Oxidative Stress
  • Molecular Weight
  • Superoxide
  • Free Radicals
  • Column Chromatography
  • Hydrolysates
  • Antioxidants
  • Column Chromatography
  • Filtration
  • Free Radicals
  • Hydrolysates
  • Molecular Weight
  • Oxidative Stress
  • Risk Assessment
  • Superoxide
  • Ultrafiltration
  • Microorganisms & Parasites
ispartof: Food & Function, 2013, Vol.4(3), pp.476-480
description: Studies have found that natural antioxidants, which are free-radical scavengers, can reduce the risk of diseases caused by free radicals. This work investigated the antioxidant properties of duck proteins hydrolysates. The free-radical scavenging function of CP-1 ( M r > 10 kDa), CP-2 (5 kDa < M r < 10 kDa) and CP-3 ( M r < 5 kDa), obtained through ultrafiltration and gel filtration were evaluated. The results showed that the lower molecular weight fraction exhibited a stronger free-radical scavenging ability. The highest free-radical scavenging activity was detected in the fraction of p4 purified from CP-3 using Sephadex G-15 column chromatography. The 50% inhibitory value (IC 50 ) of p4 for scavenging radicals of superoxide, hydroxyl and 1,1-diphenyl-2-pycrylhydrazyl (DPPH) were, respectively, 0.97 mg mL 1 , 0.84 mg mL 1 and 1.84 mg mL 1 . Furthermore, the p4 fraction at a concentration of 10 g mL 1 increased cell viability from 84.8% to 94% under antioxidative stress in neuroblastoma SK-N-SH cells.
language:
source:
identifier: ISSN: 2042-6496 ; E-ISSN: 2042-650X ; DOI: 10.1039/c2fo30264k
fulltext: fulltext
issn:
  • 2042-6496
  • 2042-650X
  • 2042650X
  • 20426496
url: Link


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titleAntioxidant activity and oxidative stress protection of duck proteins hydrolysates in SK-N-SH cells
creatorGuo, Yuxing ; Pan, Daodong ; Wu, Zhen ; Zhao, Chuanchuan ; Cao, Jinxuan
ispartofFood & Function, 2013, Vol.4(3), pp.476-480
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descriptionStudies have found that natural antioxidants, which are free-radical scavengers, can reduce the risk of diseases caused by free radicals. This work investigated the antioxidant properties of duck proteins hydrolysates. The free-radical scavenging function of CP-1 ( M r > 10 kDa), CP-2 (5 kDa < M r < 10 kDa) and CP-3 ( M r < 5 kDa), obtained through ultrafiltration and gel filtration were evaluated. The results showed that the lower molecular weight fraction exhibited a stronger free-radical scavenging ability. The highest free-radical scavenging activity was detected in the fraction of p4 purified from CP-3 using Sephadex G-15 column chromatography. The 50% inhibitory value (IC 50 ) of p4 for scavenging radicals of superoxide, hydroxyl and 1,1-diphenyl-2-pycrylhydrazyl (DPPH) were, respectively, 0.97 mg mL 1 , 0.84 mg mL 1 and 1.84 mg mL 1 . Furthermore, the p4 fraction at a concentration of 10 g mL 1 increased cell viability from 84.8% to 94% under antioxidative stress in neuroblastoma SK-N-SH cells.
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subjectUltrafiltration ; Risk Assessment ; Filtration ; Antioxidants ; Oxidative Stress ; Molecular Weight ; Superoxide ; Free Radicals ; Column Chromatography ; Hydrolysates ; Antioxidants ; Column Chromatography ; Filtration ; Free Radicals ; Hydrolysates ; Molecular Weight ; Oxidative Stress ; Risk Assessment ; Superoxide ; Ultrafiltration ; Microorganisms & Parasites;
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titleAntioxidant activity and oxidative stress protection of duck proteins hydrolysates in SK-N-SH cells
descriptionStudies have found that natural antioxidants, which are free-radical scavengers, can reduce the risk of diseases caused by free radicals. This work investigated the antioxidant properties of duck proteins hydrolysates. The free-radical scavenging function of CP-1 ( M r > 10 kDa), CP-2 (5 kDa < M r < 10 kDa) and CP-3 ( M r < 5 kDa), obtained through ultrafiltration and gel filtration were evaluated. The results showed that the lower molecular weight fraction exhibited a stronger free-radical scavenging ability. The highest free-radical scavenging activity was detected in the fraction of p4 purified from CP-3 using Sephadex G-15 column chromatography. The 50% inhibitory value (IC 50 ) of p4 for scavenging radicals of superoxide, hydroxyl and 1,1-diphenyl-2-pycrylhydrazyl (DPPH) were, respectively, 0.97 mg mL 1 , 0.84 mg mL 1 and 1.84 mg mL 1 . Furthermore, the p4 fraction at a concentration of 10 g mL 1 increased cell viability from 84.8% to 94% under antioxidative stress in neuroblastoma SK-N-SH cells.
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abstractStudies have found that natural antioxidants, which are free-radical scavengers, can reduce the risk of diseases caused by free radicals. This work investigated the antioxidant properties of duck proteins hydrolysates. The free-radical scavenging function of CP-1 ( M r > 10 kDa), CP-2 (5 kDa < M r < 10 kDa) and CP-3 ( M r < 5 kDa), obtained through ultrafiltration and gel filtration were evaluated. The results showed that the lower molecular weight fraction exhibited a stronger free-radical scavenging ability. The highest free-radical scavenging activity was detected in the fraction of p4 purified from CP-3 using Sephadex G-15 column chromatography. The 50% inhibitory value (IC 50 ) of p4 for scavenging radicals of superoxide, hydroxyl and 1,1-diphenyl-2-pycrylhydrazyl (DPPH) were, respectively, 0.97 mg mL 1 , 0.84 mg mL 1 and 1.84 mg mL 1 . Furthermore, the p4 fraction at a concentration of 10 g mL 1 increased cell viability from 84.8% to 94% under antioxidative stress in neuroblastoma SK-N-SH cells.
doi10.1039/c2fo30264k
pages476-480
date2013-02-26