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Stabilized porous liposomes with encapsulated Gd-labeled dextran as a highly efficient MRI contrast agent

A highly efficient contrast agent for magnetic resonance imaging was developed by encapsulating gadolinium within a stabilized porous liposome. The highly porous membrane leads to a high relaxivity of the encapsulated Gd. The stability of the liposome was improved by forming a polymer network within... Full description

Journal Title: Chemical Communications 2014, Vol.50(19), pp.2502-2504
Main Author: Cheng, Zhiliang
Other Authors: Al Zaki, Ajlan , Jones, Ian W. , Hall, Henry K. , Aspinwall, Craig A. , Tsourkas, Andrew
Format: Electronic Article Electronic Article
Language:
Subjects:
ID: ISSN: 1359-7345 ; E-ISSN: 1364-548X ; DOI: 10.1039/c3cc48939f
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recordid: rscc3cc48939f
title: Stabilized porous liposomes with encapsulated Gd-labeled dextran as a highly efficient MRI contrast agent
format: Article
creator:
  • Cheng, Zhiliang
  • Al Zaki, Ajlan
  • Jones, Ian W.
  • Hall, Henry K.
  • Aspinwall, Craig A.
  • Tsourkas, Andrew
subjects:
  • Contrast Media -- Chemistry
  • Dextrans -- Chemistry
  • Fluorescein-5-Isothiocyanate -- Analogs & Derivatives
  • Gadolinium -- Chemistry
  • Heterocyclic Compounds -- Chemistry
  • Liposomes -- Chemistry
  • Organometallic Compounds -- Chemistry
  • Phosphatidylcholines -- Chemistry
ispartof: Chemical Communications, 2014, Vol.50(19), pp.2502-2504
description: A highly efficient contrast agent for magnetic resonance imaging was developed by encapsulating gadolinium within a stabilized porous liposome. The highly porous membrane leads to a high relaxivity of the encapsulated Gd. The stability of the liposome was improved by forming a polymer network within the bilayer membrane.
language:
source:
identifier: ISSN: 1359-7345 ; E-ISSN: 1364-548X ; DOI: 10.1039/c3cc48939f
fulltext: fulltext
issn:
  • 1359-7345
  • 1364-548X
  • 1364548X
  • 13597345
url: Link


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titleStabilized porous liposomes with encapsulated Gd-labeled dextran as a highly efficient MRI contrast agent
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descriptionA highly efficient contrast agent for magnetic resonance imaging was developed by encapsulating gadolinium within a stabilized porous liposome. The highly porous membrane leads to a high relaxivity of the encapsulated Gd. The stability of the liposome was improved by forming a polymer network within the bilayer membrane.
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subjectContrast Media -- Chemistry ; Dextrans -- Chemistry ; Fluorescein-5-Isothiocyanate -- Analogs & Derivatives ; Gadolinium -- Chemistry ; Heterocyclic Compounds -- Chemistry ; Liposomes -- Chemistry ; Organometallic Compounds -- Chemistry ; Phosphatidylcholines -- Chemistry;
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titleStabilized porous liposomes with encapsulated Gd-labeled dextran as a highly efficient MRI contrast agent
authorCheng, Zhiliang ; Al Zaki, Ajlan ; Jones, Ian W. ; Hall, Henry K. ; Aspinwall, Craig A. ; Tsourkas, Andrew
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abstractA highly efficient contrast agent for magnetic resonance imaging was developed by encapsulating gadolinium within a stabilized porous liposome. The highly porous membrane leads to a high relaxivity of the encapsulated Gd. The stability of the liposome was improved by forming a polymer network within the bilayer membrane.
doi10.1039/c3cc48939f
pages2502-4
date2014-02-07