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Mimicking the 2-oxoglutaric acid signalling function using molecular probes: insights from structural and functional investigations

2-Oxoglutaric acid (2-OG) has gained considerable attention because of its newly discovered signalling role in addition to its established metabolic functions. With the aim of further exploring the signalling function of 2-OG, here we present a structureactivity relationship study using 2-OG probes... Full description

Journal Title: Organic & Biomolecular Chemistry 2014, Vol.12(26), pp.4723-4729
Main Author: Wang, Yang
Other Authors: Liu, Xinjun , Laurini, Erik , Posocco, Paola , Ziarelli, Fabio , Fermeglia, Maurizio , Qu, Fanqi , Pricl, Sabrina , Zhang, Cheng-Cai , Peng, Ling
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ID: ISSN: 1477-0520 ; E-ISSN: 1477-0539 ; DOI: 10.1039/c4ob00630e
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recordid: rscc4ob00630e
title: Mimicking the 2-oxoglutaric acid signalling function using molecular probes: insights from structural and functional investigations
format: Article
creator:
  • Wang, Yang
  • Liu, Xinjun
  • Laurini, Erik
  • Posocco, Paola
  • Ziarelli, Fabio
  • Fermeglia, Maurizio
  • Qu, Fanqi
  • Pricl, Sabrina
  • Zhang, Cheng-Cai
  • Peng, Ling
subjects:
  • Signal Transduction
  • Ketoglutaric Acids -- Metabolism
  • Molecular Probes -- Chemistry
ispartof: Organic & Biomolecular Chemistry, 2014, Vol.12(26), pp.4723-4729
description: 2-Oxoglutaric acid (2-OG) has gained considerable attention because of its newly discovered signalling role in addition to its established metabolic functions. With the aim of further exploring the signalling function of 2-OG, here we present a structureactivity relationship study using 2-OG probes bearing different carbon chain lengths and terminal groups. Our results highlight the importance of the five-membered carbon molecular skeleton and of the two carboxylic terminals in maintaining the signalling functions of the parent molecule 2-OG. These findings provide valuable information for designing new, effective molecular probes able to dissect and discriminate the newly discovered, complex signalling role of 2-OG from its canonical activity in metabolism.
language:
source:
identifier: ISSN: 1477-0520 ; E-ISSN: 1477-0539 ; DOI: 10.1039/c4ob00630e
fulltext: fulltext
issn:
  • 1477-0520
  • 1477-0539
  • 14770539
  • 14770520
url: Link


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titleMimicking the 2-oxoglutaric acid signalling function using molecular probes: insights from structural and functional investigations
creatorWang, Yang ; Liu, Xinjun ; Laurini, Erik ; Posocco, Paola ; Ziarelli, Fabio ; Fermeglia, Maurizio ; Qu, Fanqi ; Pricl, Sabrina ; Zhang, Cheng-Cai ; Peng, Ling
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description2-Oxoglutaric acid (2-OG) has gained considerable attention because of its newly discovered signalling role in addition to its established metabolic functions. With the aim of further exploring the signalling function of 2-OG, here we present a structureactivity relationship study using 2-OG probes bearing different carbon chain lengths and terminal groups. Our results highlight the importance of the five-membered carbon molecular skeleton and of the two carboxylic terminals in maintaining the signalling functions of the parent molecule 2-OG. These findings provide valuable information for designing new, effective molecular probes able to dissect and discriminate the newly discovered, complex signalling role of 2-OG from its canonical activity in metabolism.
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subjectSignal Transduction ; Ketoglutaric Acids -- Metabolism ; Molecular Probes -- Chemistry;
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titleMimicking the 2-oxoglutaric acid signalling function using molecular probes: insights from structural and functional investigations
description2-Oxoglutaric acid (2-OG) has gained considerable attention because of its newly discovered signalling role in addition to its established metabolic functions. With the aim of further exploring the signalling function of 2-OG, here we present a structureactivity relationship study using 2-OG probes bearing different carbon chain lengths and terminal groups. Our results highlight the importance of the five-membered carbon molecular skeleton and of the two carboxylic terminals in maintaining the signalling functions of the parent molecule 2-OG. These findings provide valuable information for designing new, effective molecular probes able to dissect and discriminate the newly discovered, complex signalling role of 2-OG from its canonical activity in metabolism.
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titleMimicking the 2-oxoglutaric acid signalling function using molecular probes: insights from structural and functional investigations
authorWang, Yang ; Liu, Xinjun ; Laurini, Erik ; Posocco, Paola ; Ziarelli, Fabio ; Fermeglia, Maurizio ; Qu, Fanqi ; Pricl, Sabrina ; Zhang, Cheng-Cai ; Peng, Ling
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abstract2-Oxoglutaric acid (2-OG) has gained considerable attention because of its newly discovered signalling role in addition to its established metabolic functions. With the aim of further exploring the signalling function of 2-OG, here we present a structureactivity relationship study using 2-OG probes bearing different carbon chain lengths and terminal groups. Our results highlight the importance of the five-membered carbon molecular skeleton and of the two carboxylic terminals in maintaining the signalling functions of the parent molecule 2-OG. These findings provide valuable information for designing new, effective molecular probes able to dissect and discriminate the newly discovered, complex signalling role of 2-OG from its canonical activity in metabolism.
doi10.1039/c4ob00630e
pages4723-4729
date2014-06-11