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Pd/C as an efficient heterogeneous catalyst for carbonylative four-component synthesis of 4(3 H )-quinazolinones

Quinazolinones are of interest in the fields of pharmaceuticals and medicinal chemistry. The application of palladium on activated charcoal (Pd/C) as a heterogeneous catalyst was investigated for the carbonylation of 2-iodoanilines with trimethyl orthoformate and amines via a multicomponent reaction... Full description

Journal Title: Catalysis Science & Technology 2015, Vol.5(9), pp.4474-4480
Main Author: Natte, Kishore
Other Authors: Neumann, Helfried , Wu, Xiao-Feng
Format: Electronic Article Electronic Article
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ID: ISSN: 2044-4753 ; E-ISSN: 2044-4761 ; DOI: 10.1039/c5cy00907c
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recordid: rscc5cy00907c
title: Pd/C as an efficient heterogeneous catalyst for carbonylative four-component synthesis of 4(3 H )-quinazolinones
format: Article
creator:
  • Natte, Kishore
  • Neumann, Helfried
  • Wu, Xiao-Feng
subjects:
  • Medicines:Drug
  • Palladium
  • Amines
  • Phosphane
  • Ligands
  • Heterogeneous-Catalysts
  • Carbonylation
  • Activated-Charcoal
  • Pharmaka
  • Palladium
  • Amin
  • Phosphin
  • Ligand
  • Heterogener Katalysator
  • Carbonylierung
  • Aktivkohle
  • Chemistry
ispartof: Catalysis Science & Technology, 2015, Vol.5(9), pp.4474-4480
description: Quinazolinones are of interest in the fields of pharmaceuticals and medicinal chemistry. The application of palladium on activated charcoal (Pd/C) as a heterogeneous catalyst was investigated for the carbonylation of 2-iodoanilines with trimethyl orthoformate and amines via a multicomponent reaction approach, which provided excellent yields of 4(3 H )-quinazolinones. It avoids the use of expensive phosphine ligands with an additional advantage of catalyst recovery. Furthermore, >5 new quinazolinone scaffolds containing the trifluoroethyl group were introduced by this procedure; gram scale experiments were successfully performed as well.
language:
source:
identifier: ISSN: 2044-4753 ; E-ISSN: 2044-4761 ; DOI: 10.1039/c5cy00907c
fulltext: fulltext
issn:
  • 2044-4753
  • 2044-4761
  • 20444761
  • 20444753
url: Link


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titlePd/C as an efficient heterogeneous catalyst for carbonylative four-component synthesis of 4(3 H )-quinazolinones
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descriptionQuinazolinones are of interest in the fields of pharmaceuticals and medicinal chemistry. The application of palladium on activated charcoal (Pd/C) as a heterogeneous catalyst was investigated for the carbonylation of 2-iodoanilines with trimethyl orthoformate and amines via a multicomponent reaction approach, which provided excellent yields of 4(3 H )-quinazolinones. It avoids the use of expensive phosphine ligands with an additional advantage of catalyst recovery. Furthermore, >5 new quinazolinone scaffolds containing the trifluoroethyl group were introduced by this procedure; gram scale experiments were successfully performed as well.
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subjectMedicines:Drug ; Palladium ; Amines ; Phosphane ; Ligands ; Heterogeneous-Catalysts ; Carbonylation ; Activated-Charcoal ; Pharmaka ; Palladium ; Amin ; Phosphin ; Ligand ; Heterogener Katalysator ; Carbonylierung ; Aktivkohle ; Chemistry;
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titlePd/C as an efficient heterogeneous catalyst for carbonylative four-component synthesis of 4(3 H )-quinazolinones
descriptionQuinazolinones are of interest in the fields of pharmaceuticals and medicinal chemistry. The application of palladium on activated charcoal (Pd/C) as a heterogeneous catalyst was investigated for the carbonylation of 2-iodoanilines with trimethyl orthoformate and amines via a multicomponent reaction approach, which provided excellent yields of 4(3 H )-quinazolinones. It avoids the use of expensive phosphine ligands with an additional advantage of catalyst recovery. Furthermore, >5 new quinazolinone scaffolds containing the trifluoroethyl group were introduced by this procedure; gram scale experiments were successfully performed as well.
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abstractQuinazolinones are of interest in the fields of pharmaceuticals and medicinal chemistry. The application of palladium on activated charcoal (Pd/C) as a heterogeneous catalyst was investigated for the carbonylation of 2-iodoanilines with trimethyl orthoformate and amines via a multicomponent reaction approach, which provided excellent yields of 4(3 H )-quinazolinones. It avoids the use of expensive phosphine ligands with an additional advantage of catalyst recovery. Furthermore, >5 new quinazolinone scaffolds containing the trifluoroethyl group were introduced by this procedure; gram scale experiments were successfully performed as well.
doi10.1039/c5cy00907c
pages4474-4480
date2015-08-17