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Inspiring process innovation via an improved green manufacturing metric: iGAL

Following our goal to devise a unified green chemistry metric that inspires innovation in sustainable drug manufacturing across the pharmaceutical industry, we herein disclose joint efforts by IQ, the ACS GCI PR and academia, leading to the significantly improved innovation Green Aspiration Level (i... Full description

Journal Title: Green Chemistry 2018, Vol.20(10), pp.2206-2211
Main Author: Roschangar, Frank
Other Authors: Zhou, Yanyan , Constable, David J. C. , Colberg, Juan , Dickson, David P. , Dunn, Peter J. , Eastgate, Martin D. , Gallou, Fabrice , Hayler, John D. , Koenig, Stefan G. , Kopach, Michael E. , Leahy, David K. , Mergelsberg, Ingrid , Scholz, Ulrich , Smith, Austin G. , Henry, Manuel , Mulder, Jason , Brandenburg, Jrg , Dehli, Juan R. , Fandrick, Daniel R. , Fandrick, Keith R. , Gnad-Badouin, Frieder , Zerban, Georg , Groll, Klaus , Anastas, Paul T. , Sheldon, Roger A. , Senanayake, Chris H.
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ID: ISSN: 1463-9262 ; E-ISSN: 1463-9270 ; DOI: 10.1039/c8gc00616d
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recordid: rscc8gc00616d
title: Inspiring process innovation via an improved green manufacturing metric: iGAL
format: Article
creator:
  • Roschangar, Frank
  • Zhou, Yanyan
  • Constable, David J. C.
  • Colberg, Juan
  • Dickson, David P.
  • Dunn, Peter J.
  • Eastgate, Martin D.
  • Gallou, Fabrice
  • Hayler, John D.
  • Koenig, Stefan G.
  • Kopach, Michael E.
  • Leahy, David K.
  • Mergelsberg, Ingrid
  • Scholz, Ulrich
  • Smith, Austin G.
  • Henry, Manuel
  • Mulder, Jason
  • Brandenburg, Jrg
  • Dehli, Juan R.
  • Fandrick, Daniel R.
  • Fandrick, Keith R.
  • Gnad-Badouin, Frieder
  • Zerban, Georg
  • Groll, Klaus
  • Anastas, Paul T.
  • Sheldon, Roger A.
  • Senanayake, Chris H.
subjects:
  • Statistical-Process
  • Sustainable-Manufacturing
  • Manufacturing-Operation
  • Waste-Avoidance
  • Green-Chemistry
  • Pharmaceutical-Industry
  • Calculating-Machines
  • Molecular-Mass
  • Statistische Analyse
  • Nachhaltige Fertigung
  • Produktionsprozess
  • Abfallverminderung
  • Grüne Chemie
  • Pharmazeutische Industrie
  • Kalkulator
  • Molekulargewicht
  • Engineering
  • Environmental Sciences
  • Chemistry
ispartof: Green Chemistry, 2018, Vol.20(10), pp.2206-2211
description: Following our goal to devise a unified green chemistry metric that inspires innovation in sustainable drug manufacturing across the pharmaceutical industry, we herein disclose joint efforts by IQ, the ACS GCI PR and academia, leading to the significantly improved innovation Green Aspiration Level (iGAL) methodology. Backed by the statistical analysis of 64 drug manufacturing processes encompassing 703 steps across 12 companies, we find that iGAL affords an excellent proxy for molecular complexity and presents a valuable molecular weight-based fixed goal. iGAL thereby accurately captures the impact of green process inventiveness and improvements, making it a useful innovation-driven green metric. We conclude by introducing the comprehensive, yet easy-to-use and readily adaptable Green Chemistry Innovation Scorecard web calculator, whose graphical output clearly and effectively illustrates the impact of innovation on waste reduction during drug manufacture.
language:
source:
identifier: ISSN: 1463-9262 ; E-ISSN: 1463-9270 ; DOI: 10.1039/c8gc00616d
fulltext: no_fulltext
issn:
  • 1463-9262
  • 1463-9270
  • 14639270
  • 14639262
url: Link


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titleInspiring process innovation via an improved green manufacturing metric: iGAL
creatorRoschangar, Frank ; Zhou, Yanyan ; Constable, David J. C. ; Colberg, Juan ; Dickson, David P. ; Dunn, Peter J. ; Eastgate, Martin D. ; Gallou, Fabrice ; Hayler, John D. ; Koenig, Stefan G. ; Kopach, Michael E. ; Leahy, David K. ; Mergelsberg, Ingrid ; Scholz, Ulrich ; Smith, Austin G. ; Henry, Manuel ; Mulder, Jason ; Brandenburg, Jrg ; Dehli, Juan R. ; Fandrick, Daniel R. ; Fandrick, Keith R. ; Gnad-Badouin, Frieder ; Zerban, Georg ; Groll, Klaus ; Anastas, Paul T. ; Sheldon, Roger A. ; Senanayake, Chris H.
ispartofGreen Chemistry, 2018, Vol.20(10), pp.2206-2211
identifier
descriptionFollowing our goal to devise a unified green chemistry metric that inspires innovation in sustainable drug manufacturing across the pharmaceutical industry, we herein disclose joint efforts by IQ, the ACS GCI PR and academia, leading to the significantly improved innovation Green Aspiration Level (iGAL) methodology. Backed by the statistical analysis of 64 drug manufacturing processes encompassing 703 steps across 12 companies, we find that iGAL affords an excellent proxy for molecular complexity and presents a valuable molecular weight-based fixed goal. iGAL thereby accurately captures the impact of green process inventiveness and improvements, making it a useful innovation-driven green metric. We conclude by introducing the comprehensive, yet easy-to-use and readily adaptable Green Chemistry Innovation Scorecard web calculator, whose graphical output clearly and effectively illustrates the impact of innovation on waste reduction during drug manufacture.
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subjectStatistical-Process ; Sustainable-Manufacturing ; Manufacturing-Operation ; Waste-Avoidance ; Green-Chemistry ; Pharmaceutical-Industry ; Calculating-Machines ; Molecular-Mass ; Statistische Analyse ; Nachhaltige Fertigung ; Produktionsprozess ; Abfallverminderung ; Grüne Chemie ; Pharmazeutische Industrie ; Kalkulator ; Molekulargewicht ; Engineering ; Environmental Sciences ; Chemistry;
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titleInspiring process innovation via an improved green manufacturing metric: iGAL
descriptionFollowing our goal to devise a unified green chemistry metric that inspires innovation in sustainable drug manufacturing across the pharmaceutical industry, we herein disclose joint efforts by IQ, the ACS GCI PR and academia, leading to the significantly improved innovation Green Aspiration Level (iGAL) methodology. Backed by the statistical analysis of 64 drug manufacturing processes encompassing 703 steps across 12 companies, we find that iGAL affords an excellent proxy for molecular complexity and presents a valuable molecular weight-based fixed goal. iGAL thereby accurately captures the impact of green process inventiveness and improvements, making it a useful innovation-driven green metric. We conclude by introducing the comprehensive, yet easy-to-use and readily adaptable Green Chemistry Innovation Scorecard web calculator, whose graphical output clearly and effectively illustrates the impact of innovation on waste reduction during drug manufacture.
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authorRoschangar, Frank ; Zhou, Yanyan ; Constable, David J. C. ; Colberg, Juan ; Dickson, David P. ; Dunn, Peter J. ; Eastgate, Martin D. ; Gallou, Fabrice ; Hayler, John D. ; Koenig, Stefan G. ; Kopach, Michael E. ; Leahy, David K. ; Mergelsberg, Ingrid ; Scholz, Ulrich ; Smith, Austin G. ; Henry, Manuel ; Mulder, Jason ; Brandenburg, Jrg ; Dehli, Juan R. ; Fandrick, Daniel R. ; Fandrick, Keith R. ; Gnad-Badouin, Frieder ; Zerban, Georg ; Groll, Klaus ; Anastas, Paul T. ; Sheldon, Roger A. ; Senanayake, Chris H.
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15Henry,Manuel
16Mulder,Jason
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18Dehli,Juan R.
19Fandrick,Daniel R.
20Fandrick,Keith R.
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7Gallou, Fabrice
8Hayler, John D.
9Koenig, Stefan G.
10Kopach, Michael E.
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12Mergelsberg, Ingrid
13Scholz, Ulrich
14Smith, Austin G.
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16Mulder, Jason
17Brandenburg, Jrg
18Dehli, Juan R.
19Fandrick, Daniel R.
20Fandrick, Keith R.
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abstractFollowing our goal to devise a unified green chemistry metric that inspires innovation in sustainable drug manufacturing across the pharmaceutical industry, we herein disclose joint efforts by IQ, the ACS GCI PR and academia, leading to the significantly improved innovation Green Aspiration Level (iGAL) methodology. Backed by the statistical analysis of 64 drug manufacturing processes encompassing 703 steps across 12 companies, we find that iGAL affords an excellent proxy for molecular complexity and presents a valuable molecular weight-based fixed goal. iGAL thereby accurately captures the impact of green process inventiveness and improvements, making it a useful innovation-driven green metric. We conclude by introducing the comprehensive, yet easy-to-use and readily adaptable Green Chemistry Innovation Scorecard web calculator, whose graphical output clearly and effectively illustrates the impact of innovation on waste reduction during drug manufacture.
doi10.1039/c8gc00616d
pages2206-2211
date2018-05-21