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A printable voltammetric genosensor for tumour suppressor gene screening based on a nanocomposite of Ceria NPsGO/nano-PANI

A novel voltammetric screen printed genosensor has been developed for detecting mutation in a particular sequence of the adenomatous polyposis coli (APC) gene, which is classified as a tumor suppressor gene. This gene prevents uncontrolled growth of cells which can cause cancerous tumors. For this p... Full description

Journal Title: New Journal of Chemistry 2018, Vol.42(19), pp.15655-15662
Main Author: Eskandari, Mahboubeh
Other Authors: Faridbod, Farnoush
Format: Electronic Article Electronic Article
Language:
Subjects:
ID: ISSN: 1144-0546 ; E-ISSN: 1369-9261 ; DOI: 10.1039/c8nj02437e
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recordid: rscc8nj02437e
title: A printable voltammetric genosensor for tumour suppressor gene screening based on a nanocomposite of Ceria NPsGO/nano-PANI
format: Article
creator:
  • Eskandari, Mahboubeh
  • Faridbod, Farnoush
subjects:
  • Polyanilines
  • Tumors
  • Ruthenium Compounds
  • Voltammetry
  • Nanocomposites
  • Ruthenium
  • Nanocomposites
  • Cerium Oxides
  • Voltammetry
  • Deoxyribonucleic Acid–DNA
ispartof: New Journal of Chemistry, 2018, Vol.42(19), pp.15655-15662
description: A novel voltammetric screen printed genosensor has been developed for detecting mutation in a particular sequence of the adenomatous polyposis coli (APC) gene, which is classified as a tumor suppressor gene. This gene prevents uncontrolled growth of cells which can cause cancerous tumors. For this purpose, a screen-printed carbon electrode (SPCE) surface was modified with a nano-polyaniline (nano-PANI) and graphene oxide (GO)-ceria nanocomposite (Ceria NPsGO/nano-PANI/SPCE). Ceria NPsGO was a suitable base for label-free immobilizaition of a single strand oligonucleotide probe. The composite was able to catalyze a difference pulse voltammetry (DPV) redox signal of Tris(bipyridine) ruthenium( ii ) chloride utilized as a redox probe for monitoring the hybridization of DNA. The genosensor displayed excellent performance over the linear range from 1 10 5 to 5 10 2 mol L 1 with a limit of detection of 5.7 10 6 mol L 1 . Also, it can distinguish a target sequence from three mismatch base sequences successfully.
language:
source:
identifier: ISSN: 1144-0546 ; E-ISSN: 1369-9261 ; DOI: 10.1039/c8nj02437e
fulltext: fulltext
issn:
  • 1144-0546
  • 1369-9261
  • 13699261
  • 11440546
url: Link


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titleA printable voltammetric genosensor for tumour suppressor gene screening based on a nanocomposite of Ceria NPsGO/nano-PANI
creatorEskandari, Mahboubeh ; Faridbod, Farnoush
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descriptionA novel voltammetric screen printed genosensor has been developed for detecting mutation in a particular sequence of the adenomatous polyposis coli (APC) gene, which is classified as a tumor suppressor gene. This gene prevents uncontrolled growth of cells which can cause cancerous tumors. For this purpose, a screen-printed carbon electrode (SPCE) surface was modified with a nano-polyaniline (nano-PANI) and graphene oxide (GO)-ceria nanocomposite (Ceria NPsGO/nano-PANI/SPCE). Ceria NPsGO was a suitable base for label-free immobilizaition of a single strand oligonucleotide probe. The composite was able to catalyze a difference pulse voltammetry (DPV) redox signal of Tris(bipyridine) ruthenium( ii ) chloride utilized as a redox probe for monitoring the hybridization of DNA. The genosensor displayed excellent performance over the linear range from 1 10 5 to 5 10 2 mol L 1 with a limit of detection of 5.7 10 6 mol L 1 . Also, it can distinguish a target sequence from three mismatch base sequences successfully.
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subjectPolyanilines ; Tumors ; Ruthenium Compounds ; Voltammetry ; Nanocomposites ; Ruthenium ; Nanocomposites ; Cerium Oxides ; Voltammetry ; Deoxyribonucleic Acid–DNA;
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titleA printable voltammetric genosensor for tumour suppressor gene screening based on a nanocomposite of Ceria NPsGO/nano-PANI
descriptionA novel voltammetric screen printed genosensor has been developed for detecting mutation in a particular sequence of the adenomatous polyposis coli (APC) gene, which is classified as a tumor suppressor gene. This gene prevents uncontrolled growth of cells which can cause cancerous tumors. For this purpose, a screen-printed carbon electrode (SPCE) surface was modified with a nano-polyaniline (nano-PANI) and graphene oxide (GO)-ceria nanocomposite (Ceria NPsGO/nano-PANI/SPCE). Ceria NPsGO was a suitable base for label-free immobilizaition of a single strand oligonucleotide probe. The composite was able to catalyze a difference pulse voltammetry (DPV) redox signal of Tris(bipyridine) ruthenium( ii ) chloride utilized as a redox probe for monitoring the hybridization of DNA. The genosensor displayed excellent performance over the linear range from 1 10 5 to 5 10 2 mol L 1 with a limit of detection of 5.7 10 6 mol L 1 . Also, it can distinguish a target sequence from three mismatch base sequences successfully.
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abstractA novel voltammetric screen printed genosensor has been developed for detecting mutation in a particular sequence of the adenomatous polyposis coli (APC) gene, which is classified as a tumor suppressor gene. This gene prevents uncontrolled growth of cells which can cause cancerous tumors. For this purpose, a screen-printed carbon electrode (SPCE) surface was modified with a nano-polyaniline (nano-PANI) and graphene oxide (GO)-ceria nanocomposite (Ceria NPsGO/nano-PANI/SPCE). Ceria NPsGO was a suitable base for label-free immobilizaition of a single strand oligonucleotide probe. The composite was able to catalyze a difference pulse voltammetry (DPV) redox signal of Tris(bipyridine) ruthenium( ii ) chloride utilized as a redox probe for monitoring the hybridization of DNA. The genosensor displayed excellent performance over the linear range from 1 10 5 to 5 10 2 mol L 1 with a limit of detection of 5.7 10 6 mol L 1 . Also, it can distinguish a target sequence from three mismatch base sequences successfully.
doi10.1039/c8nj02437e
pages15655-15662
date2018-09-24