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Relationship of classical and non-classical risk factors with genetic variants relevant to coronary heart disease

Background In addition to the well established cardiovascular risk factors, evidence suggests a possible role of genetic and non-classical risk factors in the development and progression of atherothrombosis. We aimed to determine the relationship of classical and non-classical cardiovascular risk fa... Full description

Journal Title: European Journal of Preventive Cardiology October 2006, Vol.13(5), pp.738-744
Main Author: Manresa, Josep Maria
Other Authors: Zamora, Alberto , Tomás, Marta , Sentí, Mariano , Fitó, Montserrat , Covas, María Isabel , Alcántara, Mercedes , Latorre, Glória , Escurriol, Verónica , Domingues, Sophie , Marrugat, Jaume
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 2047-4873 ; E-ISSN: 2047-4881 ; DOI: 10.1097/01.hjr.0000224484.80349.3f
Link: https://journals.sagepub.com/doi/full/10.1097/01.hjr.0000224484.80349.3f
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title: Relationship of classical and non-classical risk factors with genetic variants relevant to coronary heart disease
format: Article
creator:
  • Manresa, Josep Maria
  • Zamora, Alberto
  • Tomás, Marta
  • Sentí, Mariano
  • Fitó, Montserrat
  • Covas, María Isabel
  • Alcántara, Mercedes
  • Latorre, Glória
  • Escurriol, Verónica
  • Domingues, Sophie
  • Marrugat, Jaume
subjects:
  • Atherosclerosis
  • Cardiovascular Risk Factors
  • Genetic Polymorphism
  • Non-Classical Risk Factors
  • Medicine
ispartof: European Journal of Preventive Cardiology, October 2006, Vol.13(5), pp.738-744
description: Background In addition to the well established cardiovascular risk factors, evidence suggests a possible role of genetic and non-classical risk factors in the development and progression of atherothrombosis. We aimed to determine the relationship of classical and non-classical cardiovascular risk factors with candidate gene polymorphisms potentially involved in cardiovascular risk in the general Mediterranean population. Design Cross-sectional study. Methods We have determined the prevalence of classical (lipid profile, blood pressure, glycaemia, diabetes, smoking, body mass index, menopause and family history of coronary heart disease) and non-classical cardiovascular risk factors (infectious processes, homocysteinaemia, oxidative status, C-reactive protein, lipoprotein (a) and fibrinogen) in a population-based study. We analysed the relationship of these risk factors with the following five gene polymorphisms potentially involved in cardiovascular risk: ATP-binding cassette transporter A1-R219K, Peroxisome proliferator-activated receptor (PPAR)-α-L162V, Lipoprotein lipase (LPL)–HindIII, Paraoxonase (PON)1-Q192R, and Tumour necrosis factor (TNF)-α- G-308A. Results We found PPAR-α-V and LPL-H+ alleles to be associated with decreased high-density lipoprotein-cholesterol (HDL-c) concentration and with increased total cholesterol: HDL-c and triglyceride: HDL-c ratios. Regarding the non-classical risk factors, C-reactive protein concentration was higher for the PPAR-α-V allele. A higher oxidative status was shown in homozygotes for LPL-H+ and TNF-α-G alleles, although the latter also had lower homocysteinaemia. Conclusions Three of the genetic variants analysed, PPAR-α-L162V, LPL-HindIII, and TNF-α-G-308A, were associated with non-classical risk factors, specifically lipid profile, inflammation, and oxidative status.
language: eng
source:
identifier: ISSN: 2047-4873 ; E-ISSN: 2047-4881 ; DOI: 10.1097/01.hjr.0000224484.80349.3f
fulltext: fulltext
issn:
  • 2047-4873
  • 20474873
  • 2047-4881
  • 20474881
url: Link


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titleRelationship of classical and non-classical risk factors with genetic variants relevant to coronary heart disease
creatorManresa, Josep Maria ; Zamora, Alberto ; Tomás, Marta ; Sentí, Mariano ; Fitó, Montserrat ; Covas, María Isabel ; Alcántara, Mercedes ; Latorre, Glória ; Escurriol, Verónica ; Domingues, Sophie ; Marrugat, Jaume
ispartofEuropean Journal of Preventive Cardiology, October 2006, Vol.13(5), pp.738-744
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subjectAtherosclerosis ; Cardiovascular Risk Factors ; Genetic Polymorphism ; Non-Classical Risk Factors ; Medicine
descriptionBackground In addition to the well established cardiovascular risk factors, evidence suggests a possible role of genetic and non-classical risk factors in the development and progression of atherothrombosis. We aimed to determine the relationship of classical and non-classical cardiovascular risk factors with candidate gene polymorphisms potentially involved in cardiovascular risk in the general Mediterranean population. Design Cross-sectional study. Methods We have determined the prevalence of classical (lipid profile, blood pressure, glycaemia, diabetes, smoking, body mass index, menopause and family history of coronary heart disease) and non-classical cardiovascular risk factors (infectious processes, homocysteinaemia, oxidative status, C-reactive protein, lipoprotein (a) and fibrinogen) in a population-based study. We analysed the relationship of these risk factors with the following five gene polymorphisms potentially involved in cardiovascular risk: ATP-binding cassette transporter A1-R219K, Peroxisome proliferator-activated receptor (PPAR)-α-L162V, Lipoprotein lipase (LPL)–HindIII, Paraoxonase (PON)1-Q192R, and Tumour necrosis factor (TNF)-α- G-308A. Results We found PPAR-α-V and LPL-H+ alleles to be associated with decreased high-density lipoprotein-cholesterol (HDL-c) concentration and with increased total cholesterol: HDL-c and triglyceride: HDL-c ratios. Regarding the non-classical risk factors, C-reactive protein concentration was higher for the PPAR-α-V allele. A higher oxidative status was shown in homozygotes for LPL-H+ and TNF-α-G alleles, although the latter also had lower homocysteinaemia. Conclusions Three of the genetic variants analysed, PPAR-α-L162V, LPL-HindIII, and TNF-α-G-308A, were associated with non-classical risk factors, specifically lipid profile, inflammation, and oxidative status.
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titleRelationship of classical and non-classical risk factors with genetic variants relevant to coronary heart disease
description

Background In addition to the well established cardiovascular risk factors, evidence suggests a possible role of genetic and non-classical risk factors in the development and progression of atherothrombosis. We aimed to determine the relationship of classical and non-classical cardiovascular risk factors with candidate gene polymorphisms potentially involved in cardiovascular risk in the general Mediterranean population. Design Cross-sectional study. Methods We have determined the prevalence of classical (lipid profile, blood pressure, glycaemia, diabetes, smoking, body mass index, menopause and family history of coronary heart disease) and non-classical cardiovascular risk factors (infectious processes, homocysteinaemia, oxidative status, C-reactive protein, lipoprotein (a) and fibrinogen) in a population-based study. We analysed the relationship of these risk factors with the following five gene polymorphisms potentially involved in cardiovascular risk: ATP-binding cassette transporter A1-R219K, Peroxisome proliferator-activated receptor (PPAR)-α-L162V, Lipoprotein lipase (LPL)–HindIII, Paraoxonase (PON)1-Q192R, and Tumour necrosis factor (TNF)-α- G-308A. Results We found PPAR-α-V and LPL-H+ alleles to be associated with decreased high-density lipoprotein-cholesterol (HDL-c) concentration and with increased total cholesterol: HDL-c and triglyceride: HDL-c ratios. Regarding the non-classical risk factors, C-reactive protein concentration was higher for the PPAR-α-V allele. A higher oxidative status was shown in homozygotes for LPL-H+ and TNF-α-G alleles, although the latter also had lower homocysteinaemia. Conclusions Three of the genetic variants analysed, PPAR-α-L162V, LPL-HindIII, and TNF-α-G-308A, were associated with non-classical risk factors, specifically lipid profile, inflammation, and oxidative status.

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Background In addition to the well established cardiovascular risk factors, evidence suggests a possible role of genetic and non-classical risk factors in the development and progression of atherothrombosis. We aimed to determine the relationship of classical and non-classical cardiovascular risk factors with candidate gene polymorphisms potentially involved in cardiovascular risk in the general Mediterranean population. Design Cross-sectional study. Methods We have determined the prevalence of classical (lipid profile, blood pressure, glycaemia, diabetes, smoking, body mass index, menopause and family history of coronary heart disease) and non-classical cardiovascular risk factors (infectious processes, homocysteinaemia, oxidative status, C-reactive protein, lipoprotein (a) and fibrinogen) in a population-based study. We analysed the relationship of these risk factors with the following five gene polymorphisms potentially involved in cardiovascular risk: ATP-binding cassette transporter A1-R219K, Peroxisome proliferator-activated receptor (PPAR)-α-L162V, Lipoprotein lipase (LPL)–HindIII, Paraoxonase (PON)1-Q192R, and Tumour necrosis factor (TNF)-α- G-308A. Results We found PPAR-α-V and LPL-H+ alleles to be associated with decreased high-density lipoprotein-cholesterol (HDL-c) concentration and with increased total cholesterol: HDL-c and triglyceride: HDL-c ratios. Regarding the non-classical risk factors, C-reactive protein concentration was higher for the PPAR-α-V allele. A higher oxidative status was shown in homozygotes for LPL-H+ and TNF-α-G alleles, although the latter also had lower homocysteinaemia. Conclusions Three of the genetic variants analysed, PPAR-α-L162V, LPL-HindIII, and TNF-α-G-308A, were associated with non-classical risk factors, specifically lipid profile, inflammation, and oxidative status.

copLondon, England
pubSAGE Publications
doi10.1097/01.hjr.0000224484.80349.3f
lad01European Journal of Preventive Cardiology
date2006-10