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MDMA intoxication and verbal memory performance: a placebo-controlled pharmaco-MRI study

The aim of the present study was to identify the neural substrate underlying memory impairment due to a single dose of MDMA (3,4-methylenedioxymethamphetamine) by means of pharmaco-MRI. Based on previous behavioral results it was hypothesized that this deficit could be attributed to a specific influ... Full description

Journal Title: Journal of Psychopharmacology August 2011, Vol.25(8), pp.1053-1061
Main Author: Kuypers, Kim PC
Other Authors: Wingen, Marleen , Heinecke, Armin , Formisano, Elia , Ramaekers, Johannes G
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0269-8811 ; E-ISSN: 1461-7285 ; DOI: 10.1177/0269881111405361
Link: https://journals.sagepub.com/doi/full/10.1177/0269881111405361
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recordid: sage_s10_1177_0269881111405361
title: MDMA intoxication and verbal memory performance: a placebo-controlled pharmaco-MRI study
format: Article
creator:
  • Kuypers, Kim PC
  • Wingen, Marleen
  • Heinecke, Armin
  • Formisano, Elia
  • Ramaekers, Johannes G
subjects:
  • Encoding
  • Mdma
  • Pharmaco-Mri
  • Verbal Memory
  • Pharmacy, Therapeutics, & Pharmacology
  • Psychology
ispartof: Journal of Psychopharmacology, August 2011, Vol.25(8), pp.1053-1061
description: The aim of the present study was to identify the neural substrate underlying memory impairment due to a single dose of MDMA (3,4-methylenedioxymethamphetamine) by means of pharmaco-MRI. Based on previous behavioral results it was hypothesized that this deficit could be attributed to a specific influence of MDMA on encoding. Fourteen Ecstasy users participated in this double-blind, placebo-controlled, within-subject study with two treatment conditions: MDMA (75 mg) and placebo. Memory performance was tested by means of a word learning task including two words lists, one addressing reading processes (control task, CWL) and a second (experimental task, EWL) addressing encoding and reading processes. Behavioral data showed that under the influence of MDMA, EWL performance was worse than placebo. Imaging data showed that Encoding was situated mainly in (pre)frontal, temporal and parietal areas. MDMA by Encoding interaction was situated in three areas: the left middle frontal gyrus...
language: eng
source:
identifier: ISSN: 0269-8811 ; E-ISSN: 1461-7285 ; DOI: 10.1177/0269881111405361
fulltext: fulltext
issn:
  • 0269-8811
  • 02698811
  • 1461-7285
  • 14617285
url: Link


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descriptionThe aim of the present study was to identify the neural substrate underlying memory impairment due to a single dose of MDMA (3,4-methylenedioxymethamphetamine) by means of pharmaco-MRI. Based on previous behavioral results it was hypothesized that this deficit could be attributed to a specific influence of MDMA on encoding. Fourteen Ecstasy users participated in this double-blind, placebo-controlled, within-subject study with two treatment conditions: MDMA (75 mg) and placebo. Memory performance was tested by means of a word learning task including two words lists, one addressing reading processes (control task, CWL) and a second (experimental task, EWL) addressing encoding and reading processes. Behavioral data showed that under the influence of MDMA, EWL performance was worse than placebo. Imaging data showed that Encoding was situated mainly in (pre)frontal, temporal and parietal areas. MDMA by Encoding interaction was situated in three areas: the left middle frontal gyrus...
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The aim of the present study was to identify the neural substrate underlying memory impairment due to a single dose of MDMA (3,4-methylenedioxymethamphetamine) by means of pharmaco-MRI. Based on previous behavioral results it was hypothesized that this deficit could be attributed to a specific influence of MDMA on encoding. Fourteen Ecstasy users participated in this double-blind, placebo-controlled, within-subject study with two treatment conditions: MDMA (75 mg) and placebo. Memory performance was tested by means of a word learning task including two words lists, one addressing reading processes (control task, CWL) and a second (experimental task, EWL) addressing encoding and reading processes. Behavioral data showed that under the influence of MDMA, EWL performance was worse than placebo. Imaging data showed that Encoding was situated mainly in (pre)frontal, temporal and parietal areas. MDMA by Encoding interaction was situated in three areas: the left middle frontal gyrus...

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The aim of the present study was to identify the neural substrate underlying memory impairment due to a single dose of MDMA (3,4-methylenedioxymethamphetamine) by means of pharmaco-MRI. Based on previous behavioral results it was hypothesized that this deficit could be attributed to a specific influence of MDMA on encoding. Fourteen Ecstasy users participated in this double-blind, placebo-controlled, within-subject study with two treatment conditions: MDMA (75 mg) and placebo. Memory performance was tested by means of a word learning task including two words lists, one addressing reading processes (control task, CWL) and a second (experimental task, EWL) addressing encoding and reading processes. Behavioral data showed that under the influence of MDMA, EWL performance was worse than placebo. Imaging data showed that Encoding was situated mainly in (pre)frontal, temporal and parietal areas. MDMA by Encoding interaction was situated in three areas: the left middle frontal gyrus...

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