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Genetic modification of mammalian genome at chromosome level

The review is concerned with a progress in genetic modification of a mammalian genome in vitro and in vivo at chromosomal level. Recently three new approaches for the chromosome biotechnology have been developed: Using Cre/loxP-system a researcher is able to produce targeted rearrangements of whole... Full description

Journal Title: Anais da Academia Brasileira de Ciências 01 September 2000, Vol.72(3), pp.389-398
Main Author: Serov, Oleg L
Other Authors: Matveeva, Natalia M , Serova, Irina A , Borodin, Pavel M
Format: Electronic Article Electronic Article
Language: Portugiesisch
Subjects:
Mac
ID: ISSN: 1678-2690 ; E-ISSN: 1678-2690 ; DOI: 10.1590/S0001-37652000000300012
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recordid: scielo_sS0001_37652000000300012
title: Genetic modification of mammalian genome at chromosome level
format: Article
creator:
  • Serov, Oleg L
  • Matveeva, Natalia M
  • Serova, Irina A
  • Borodin, Pavel M
subjects:
  • Multidisciplinary Sciences
  • Chromosome Biotechnology
  • Cre/Loxp
  • Es Cells
  • Mac
  • Sciences (General)
ispartof: Anais da Academia Brasileira de Ciências, 01 September 2000, Vol.72(3), pp.389-398
description: The review is concerned with a progress in genetic modification of a mammalian genome in vitro and in vivo at chromosomal level. Recently three new approaches for the chromosome biotechnology have been developed: Using Cre/loxP-system a researcher is able to produce targeted rearrangements of whole chromosomes or their segments or particular genes within the genome, and therefore to modify the set, position and copy number of the endogenous elements of the genome. Mammalian artificial chromosomes (MACs) provide a possibility to introduce into genome relatively large segments of alien chromosome material, either artificially constructed or derived from the genome of different species. Using ES-somatic cell hybrids allows to transfer whole chromosomes or their fragments between different genomes within and between species. Advantages and limitations of these approaches are discussed.
language: por
source:
identifier: ISSN: 1678-2690 ; E-ISSN: 1678-2690 ; DOI: 10.1590/S0001-37652000000300012
fulltext: fulltext_linktorsrc
issn:
  • 1678-2690
  • 16782690
url: Link


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subjectMultidisciplinary Sciences ; Chromosome Biotechnology ; Cre/Loxp ; Es Cells ; Mac ; Sciences (General)
descriptionThe review is concerned with a progress in genetic modification of a mammalian genome in vitro and in vivo at chromosomal level. Recently three new approaches for the chromosome biotechnology have been developed: Using Cre/loxP-system a researcher is able to produce targeted rearrangements of whole chromosomes or their segments or particular genes within the genome, and therefore to modify the set, position and copy number of the endogenous elements of the genome. Mammalian artificial chromosomes (MACs) provide a possibility to introduce into genome relatively large segments of alien chromosome material, either artificially constructed or derived from the genome of different species. Using ES-somatic cell hybrids allows to transfer whole chromosomes or their fragments between different genomes within and between species. Advantages and limitations of these approaches are discussed.
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The review is concerned with a progress in genetic modification of a mammalian genome in vitro and in vivo at chromosomal level. Recently three new approaches for the chromosome biotechnology have been developed: Using Cre/loxP-system a researcher is able to produce targeted rearrangements of whole chromosomes or their segments or particular genes within the genome, and therefore to modify the set, position and copy number of the endogenous elements of the genome. Mammalian artificial chromosomes (MACs) provide a possibility to introduce into genome relatively large segments of alien chromosome material, either artificially constructed or derived from the genome of different species. Using ES-somatic cell hybrids allows to transfer whole chromosomes or their fragments between different genomes within and between species. Advantages and limitations of these approaches are discussed.

pubAcademia Brasileira de Ciências
doi10.1590/S0001-37652000000300012
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