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Liposomes in leishmaniasis: Therapeutic effects of antimonial drugs, 8-aminoquinolines, and tetracycline

This study investigated the role of liposomes in changing the pharmacological efficacy of anti-leishmanial drugs in hamsters infected with visceral leishmaniasis. Enhanced anti-leishmanial activity could be accounted for only by liposome-encapsulated drugs. “Empty” liposomes (lacking anti-leishmania... Full description

Journal Title: Life Sciences 1980, Vol.26(26), pp.2231-2238
Main Author: Alving, Carl R.
Other Authors: Steck, Edgar A. , Chapman, Willie L. , Waits, Virginia B. , Hendricks, Larry D. , Swartz, Glenn M. , Hanson, William L.
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0024-3205 ; DOI: 10.1016/0024-3205(80)90207-6
Link: http://dx.doi.org/10.1016/0024-3205(80)90207-6
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recordid: sciversesciencedirect_elsevier0024-3205(80)90207-6
title: Liposomes in leishmaniasis: Therapeutic effects of antimonial drugs, 8-aminoquinolines, and tetracycline
format: Article
creator:
  • Alving, Carl R.
  • Steck, Edgar A.
  • Chapman, Willie L.
  • Waits, Virginia B.
  • Hendricks, Larry D.
  • Swartz, Glenn M.
  • Hanson, William L.
subjects:
  • Aminoquinolines–Administration & Dosage
  • Animals–Therapeutic Use
  • Antimony–Administration & Dosage
  • Cricetinae–Therapeutic Use
  • Leishmaniasis, Visceral–Drug Therapy
  • Liposomes–Prevention & Control
  • Tetracycline–Administration & Dosage
  • Tetracycline–Administration & Dosage
  • Tetracycline–Therapeutic Use
  • Aminoquinolines
  • Liposomes
  • Antimony
  • Tetracycline
ispartof: Life Sciences, 1980, Vol.26(26), pp.2231-2238
description: This study investigated the role of liposomes in changing the pharmacological efficacy of anti-leishmanial drugs in hamsters infected with visceral leishmaniasis. Enhanced anti-leishmanial activity could be accounted for only by liposome-encapsulated drugs. “Empty” liposomes (lacking anti-leishmanial drug) gave no therapeutic benefit by themselves, nor did they enhance the effectiveness of concurrently administered drugs. In the absence of additional drugs, empty liposomes actually resulted in a higher mortality due to endstage leishmaniasis. Mortality associated with chronic leishmaniasis, including that induced by empty liposomes, was reduced approximately 50% by orally administered unencapsulated tetracycline. Liposome-encapsulated tetracycline, given i.c., had no anti-leishmanial activity, thus indicating that tetracycline did not have inherent anti-leishmanial properties, and was beneficial because of its anti-bacterial effects. Liposomes containing an antimonial drug were effective when given i.c., i.p., or i.m., but not when given s.c. or p.o. Liposome-encapsulated antimonial drug had prophylactic activity and was effective when administered 8 days prior, but not 17 days prior, to infection. Unencapsulated antimonial drug had no prophylactic effect. In addition to antimonials, another class of compounds, 8-aminoquinolines, had marked anti-leishmanial activity in liposomes. One of these, WR 6026, was 700 to 1800 times more effective than an antimonial drug alone.
language: eng
source:
identifier: ISSN: 0024-3205 ; DOI: 10.1016/0024-3205(80)90207-6
fulltext: fulltext
issn:
  • 00243205
  • 0024-3205
url: Link


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titleLiposomes in leishmaniasis: Therapeutic effects of antimonial drugs, 8-aminoquinolines, and tetracycline
creatorAlving, Carl R. ; Steck, Edgar A. ; Chapman, Willie L. ; Waits, Virginia B. ; Hendricks, Larry D. ; Swartz, Glenn M. ; Hanson, William L.
ispartofLife Sciences, 1980, Vol.26(26), pp.2231-2238
identifierISSN: 0024-3205 ; DOI: 10.1016/0024-3205(80)90207-6
descriptionThis study investigated the role of liposomes in changing the pharmacological efficacy of anti-leishmanial drugs in hamsters infected with visceral leishmaniasis. Enhanced anti-leishmanial activity could be accounted for only by liposome-encapsulated drugs. “Empty” liposomes (lacking anti-leishmanial drug) gave no therapeutic benefit by themselves, nor did they enhance the effectiveness of concurrently administered drugs. In the absence of additional drugs, empty liposomes actually resulted in a higher mortality due to endstage leishmaniasis. Mortality associated with chronic leishmaniasis, including that induced by empty liposomes, was reduced approximately 50% by orally administered unencapsulated tetracycline. Liposome-encapsulated tetracycline, given i.c., had no anti-leishmanial activity, thus indicating that tetracycline did not have inherent anti-leishmanial properties, and was beneficial because of its anti-bacterial effects. Liposomes containing an antimonial drug were effective when given i.c., i.p., or i.m., but not when given s.c. or p.o. Liposome-encapsulated antimonial drug had prophylactic activity and was effective when administered 8 days prior, but not 17 days prior, to infection. Unencapsulated antimonial drug had no prophylactic effect. In addition to antimonials, another class of compounds, 8-aminoquinolines, had marked anti-leishmanial activity in liposomes. One of these, WR 6026, was 700 to 1800 times more effective than an antimonial drug alone.
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subjectAminoquinolines–Administration & Dosage ; Animals–Therapeutic Use ; Antimony–Administration & Dosage ; Cricetinae–Therapeutic Use ; Leishmaniasis, Visceral–Drug Therapy ; Liposomes–Prevention & Control ; Tetracycline–Administration & Dosage ; Tetracycline–Administration & Dosage ; Tetracycline–Therapeutic Use ; Aminoquinolines ; Liposomes ; Antimony ; Tetracycline;
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descriptionThis study investigated the role of liposomes in changing the pharmacological efficacy of anti-leishmanial drugs in hamsters infected with visceral leishmaniasis. Enhanced anti-leishmanial activity could be accounted for only by liposome-encapsulated drugs. “Empty” liposomes (lacking anti-leishmanial drug) gave no therapeutic benefit by themselves, nor did they enhance the effectiveness of concurrently administered drugs. In the absence of additional drugs, empty liposomes actually resulted in a higher mortality due to endstage leishmaniasis. Mortality associated with chronic leishmaniasis, including that induced by empty liposomes, was reduced approximately 50% by orally administered unencapsulated tetracycline. Liposome-encapsulated tetracycline, given i.c., had no anti-leishmanial activity, thus indicating that tetracycline did not have inherent anti-leishmanial properties, and was beneficial because of its anti-bacterial effects. Liposomes containing an antimonial drug were effective when given i.c., i.p., or i.m., but not when given s.c. or p.o. Liposome-encapsulated antimonial drug had prophylactic activity and was effective when administered 8 days prior, but not 17 days prior, to infection. Unencapsulated antimonial drug had no prophylactic effect. In addition to antimonials, another class of compounds, 8-aminoquinolines, had marked anti-leishmanial activity in liposomes. One of these, WR 6026, was 700 to 1800 times more effective than an antimonial drug alone.
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titleLiposomes in leishmaniasis: Therapeutic effects of antimonial drugs, 8-aminoquinolines, and tetracycline
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abstractThis study investigated the role of liposomes in changing the pharmacological efficacy of anti-leishmanial drugs in hamsters infected with visceral leishmaniasis. Enhanced anti-leishmanial activity could be accounted for only by liposome-encapsulated drugs. “Empty” liposomes (lacking anti-leishmanial drug) gave no therapeutic benefit by themselves, nor did they enhance the effectiveness of concurrently administered drugs. In the absence of additional drugs, empty liposomes actually resulted in a higher mortality due to endstage leishmaniasis. Mortality associated with chronic leishmaniasis, including that induced by empty liposomes, was reduced approximately 50% by orally administered unencapsulated tetracycline. Liposome-encapsulated tetracycline, given i.c., had no anti-leishmanial activity, thus indicating that tetracycline did not have inherent anti-leishmanial properties, and was beneficial because of its anti-bacterial effects. Liposomes containing an antimonial drug were effective when given i.c., i.p., or i.m., but not when given s.c. or p.o. Liposome-encapsulated antimonial drug had prophylactic activity and was effective when administered 8 days prior, but not 17 days prior, to infection. Unencapsulated antimonial drug had no prophylactic effect. In addition to antimonials, another class of compounds, 8-aminoquinolines, had marked anti-leishmanial activity in liposomes. One of these, WR 6026, was 700 to 1800 times more effective than an antimonial drug alone.
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doi10.1016/0024-3205(80)90207-6
eissn18790631