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Antiviral effects of liposome-encapsulated PolyICLC against Dengue virus in a mouse model

This study presents the first investigation of the antiviral effects of the liposome-encapsulated PolyICLC (LE-PolyICLC) on Dengue virus (DENV) in a mouse model. In vivo efficacy studies showed that LE-PolyICLC acted to increase antiviral mechanisms mainly through promoting cytokine expression assoc... Full description

Journal Title: Biochemical and Biophysical Research Communications 16 September 2016, Vol.478(2), pp.913-918
Main Author: Hu, Yongxin
Other Authors: Hu, Yanxin , Sun, Lunquan , Wong, Jonathan , Wang, Ming
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0006-291X ; DOI: 10.1016/j.bbrc.2016.08.050
Link: http://dx.doi.org/10.1016/j.bbrc.2016.08.050
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recordid: sciversesciencedirect_elsevierS0006-291X(16)31305-5
title: Antiviral effects of liposome-encapsulated PolyICLC against Dengue virus in a mouse model
format: Article
creator:
  • Hu, Yongxin
  • Hu, Yanxin
  • Sun, Lunquan
  • Wong, Jonathan
  • Wang, Ming
subjects:
  • Antiviral
  • Le-Polyiclc
  • Dengue 2 Virus
  • Innate Immunity
ispartof: Biochemical and Biophysical Research Communications, 16 September 2016, Vol.478(2), pp.913-918
description: This study presents the first investigation of the antiviral effects of the liposome-encapsulated PolyICLC (LE-PolyICLC) on Dengue virus (DENV) in a mouse model. In vivo efficacy studies showed that LE-PolyICLC acted to increase antiviral mechanisms mainly through promoting cytokine expression associated with innate immunity, such as IFN-γ. In addition, the pro-inflammatory cytokine TNF-α was also increased, while IL-6 level was decreased in serum. The titers of total antibodies against DENV2 in mice were also elevated. Administration of LE-PolyICLC not only alleviated the loss of body weight, degree of morbidity, and pathological damage in brains, but also reduced the viral titers and expression of viral E protein in the brain. Notably, the effectiveness of LE-PolyICLC was better than PolyICLC on the basis of the data presented in this study. These results, therefore, set a foundation for further development of LE-PolyICLC as an attractive candidate of antiviral agents to be used in both prophylactic and therapeutic settings in DENV diseases. •LE-PolyICLC was tested as an antiviral agent against DENV2 in a mouse model.•LE-PolyICLC reduced the viral titers and expression of viral E protein of DENV2.•LE-PolyICLC displayed effect mainly via promoting cytokine expression, such as IFN-γ.•The effectiveness of LE-PolyICLC against DENV2 was better than PolyICLC in vivo.
language: eng
source:
identifier: ISSN: 0006-291X ; DOI: 10.1016/j.bbrc.2016.08.050
fulltext: fulltext
issn:
  • 0006291X
  • 0006-291X
url: Link


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titleAntiviral effects of liposome-encapsulated PolyICLC against Dengue virus in a mouse model
creatorHu, Yongxin ; Hu, Yanxin ; Sun, Lunquan ; Wong, Jonathan ; Wang, Ming
ispartofBiochemical and Biophysical Research Communications, 16 September 2016, Vol.478(2), pp.913-918
identifierISSN: 0006-291X ; DOI: 10.1016/j.bbrc.2016.08.050
subjectAntiviral ; Le-Polyiclc ; Dengue 2 Virus ; Innate Immunity
descriptionThis study presents the first investigation of the antiviral effects of the liposome-encapsulated PolyICLC (LE-PolyICLC) on Dengue virus (DENV) in a mouse model. In vivo efficacy studies showed that LE-PolyICLC acted to increase antiviral mechanisms mainly through promoting cytokine expression associated with innate immunity, such as IFN-γ. In addition, the pro-inflammatory cytokine TNF-α was also increased, while IL-6 level was decreased in serum. The titers of total antibodies against DENV2 in mice were also elevated. Administration of LE-PolyICLC not only alleviated the loss of body weight, degree of morbidity, and pathological damage in brains, but also reduced the viral titers and expression of viral E protein in the brain. Notably, the effectiveness of LE-PolyICLC was better than PolyICLC on the basis of the data presented in this study. These results, therefore, set a foundation for further development of LE-PolyICLC as an attractive candidate of antiviral agents to be used in both prophylactic and therapeutic settings in DENV diseases. •LE-PolyICLC was tested as an antiviral agent against DENV2 in a mouse model.•LE-PolyICLC reduced the viral titers and expression of viral E protein of DENV2.•LE-PolyICLC displayed effect mainly via promoting cytokine expression, such as IFN-γ.•The effectiveness of LE-PolyICLC against DENV2 was better than PolyICLC in vivo.
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abstractThis study presents the first investigation of the antiviral effects of the liposome-encapsulated PolyICLC (LE-PolyICLC) on Dengue virus (DENV) in a mouse model. In vivo efficacy studies showed that LE-PolyICLC acted to increase antiviral mechanisms mainly through promoting cytokine expression associated with innate immunity, such as IFN-γ. In addition, the pro-inflammatory cytokine TNF-α was also increased, while IL-6 level was decreased in serum. The titers of total antibodies against DENV2 in mice were also elevated. Administration of LE-PolyICLC not only alleviated the loss of body weight, degree of morbidity, and pathological damage in brains, but also reduced the viral titers and expression of viral E protein in the brain. Notably, the effectiveness of LE-PolyICLC was better than PolyICLC on the basis of the data presented in this study. These results, therefore, set a foundation for further development of LE-PolyICLC as an attractive candidate of antiviral agents to be used in both prophylactic and therapeutic settings in DENV diseases. •LE-PolyICLC was tested as an antiviral agent against DENV2 in a mouse model.•LE-PolyICLC reduced the viral titers and expression of viral E protein of DENV2.•LE-PolyICLC displayed effect mainly via promoting cytokine expression, such as IFN-γ.•The effectiveness of LE-PolyICLC against DENV2 was better than PolyICLC in vivo.
pubElsevier Inc.
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eissn10902104
date2016-09-16