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The Role of MDR1 C3435T Gene Polymorphism on Gingival Hyperplasia in Turkish Renal Transplant Patients Treated With Cyclosporine in the Absence of Calcium Channel Blockers

ObjectiveTo investigate the occurrence of MDR1 C3435T gene polymorphisms in the Turkish renal transplant patients treated with cyclosporine (CsA), and correlate these findings with prevalence and degree of gingival hyperplasia (GH). MethodsBefore to renal transplantation, dental treatment and oral h... Full description

Journal Title: Transplantation Proceedings July-August 2013, Vol.45(6), pp.2233-2237
Main Author: Kazancioglu, H.O.
Other Authors: Ak, G. , Turkmen, A. , Ozbek, U. , Tuncer, F.N. , Karabulut, A.
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0041-1345 ; DOI: 10.1016/j.transproceed.2012.12.007
Link: http://dx.doi.org/10.1016/j.transproceed.2012.12.007
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recordid: sciversesciencedirect_elsevierS0041-1345(12)01334-6
title: The Role of MDR1 C3435T Gene Polymorphism on Gingival Hyperplasia in Turkish Renal Transplant Patients Treated With Cyclosporine in the Absence of Calcium Channel Blockers
format: Article
creator:
  • Kazancioglu, H.O.
  • Ak, G.
  • Turkmen, A.
  • Ozbek, U.
  • Tuncer, F.N.
  • Karabulut, A.
subjects:
  • ATP Binding Cassette Transporter, Sub-Family B–Genetics
  • ATP-Binding Cassette, Sub-Family B, Member 1–Therapeutic Use
  • Adolescent–Adverse Effects
  • Adult–Diagnosis
  • Aged–Epidemiology
  • Calcium Channel Blockers–Genetics
  • Cyclosporine–Adverse Effects
  • Female–Adverse Effects
  • Gene Frequency–Epidemiology
  • Genetic Predisposition to Disease–Epidemiology
  • Gingival Hyperplasia–Epidemiology
  • Heterozygote–Epidemiology
  • Humans–Epidemiology
  • Immunosuppressive Agents–Epidemiology
  • Kidney Transplantation–Epidemiology
  • Male–Epidemiology
  • Middle Aged–Epidemiology
  • Phenotype–Epidemiology
  • Polymorphism, Genetic–Epidemiology
  • Risk Factors–Epidemiology
  • Severity of Illness Index–Epidemiology
  • Time Factors–Epidemiology
  • Treatment Outcome–Epidemiology
  • Turkey–Epidemiology
  • Young Adult–Epidemiology
  • Abcb1 Protein, Human
  • ATP Binding Cassette Transporter, Sub-Family B
  • ATP-Binding Cassette, Sub-Family B, Member 1
  • Calcium Channel Blockers
  • Immunosuppressive Agents
  • Cyclosporine
ispartof: Transplantation Proceedings, July-August 2013, Vol.45(6), pp.2233-2237
description: ObjectiveTo investigate the occurrence of MDR1 C3435T gene polymorphisms in the Turkish renal transplant patients treated with cyclosporine (CsA), and correlate these findings with prevalence and degree of gingival hyperplasia (GH). MethodsBefore to renal transplantation, dental treatment and oral hygiene education of 300 renal disease patients was completed. Peripheral blood samples were collected from 154 renal transplant recipients on CsA treatment without calcium channel blockers. MDR1 C3435T gene polymorphism and GH were analyzed at posttransplant month 6. ResultsNo difference was detected among groups for age, posttransplant period, creatine levels, serum concentration of CsA, or plaque and bleeding indices (P > .05). Out of all transplanted patients, 42.8% were found to have the heterozygote genotype. This was reduced to 37.5% when individuals with GH were taken into account. However, when degree of GH was analyzed, those with severe GH were found to have the heterozygote genotype significantly more often (P < .05). ConclusionsThe MDR1 gene polymorphism is not associated with GH frequency, but may be associated with GH severity.
language: eng
source:
identifier: ISSN: 0041-1345 ; DOI: 10.1016/j.transproceed.2012.12.007
fulltext: fulltext
issn:
  • 00411345
  • 0041-1345
url: Link


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titleThe Role of MDR1 C3435T Gene Polymorphism on Gingival Hyperplasia in Turkish Renal Transplant Patients Treated With Cyclosporine in the Absence of Calcium Channel Blockers
creatorKazancioglu, H.O. ; Ak, G. ; Turkmen, A. ; Ozbek, U. ; Tuncer, F.N. ; Karabulut, A.
ispartofTransplantation Proceedings, July-August 2013, Vol.45(6), pp.2233-2237
identifierISSN: 0041-1345 ; DOI: 10.1016/j.transproceed.2012.12.007
descriptionObjectiveTo investigate the occurrence of MDR1 C3435T gene polymorphisms in the Turkish renal transplant patients treated with cyclosporine (CsA), and correlate these findings with prevalence and degree of gingival hyperplasia (GH). MethodsBefore to renal transplantation, dental treatment and oral hygiene education of 300 renal disease patients was completed. Peripheral blood samples were collected from 154 renal transplant recipients on CsA treatment without calcium channel blockers. MDR1 C3435T gene polymorphism and GH were analyzed at posttransplant month 6. ResultsNo difference was detected among groups for age, posttransplant period, creatine levels, serum concentration of CsA, or plaque and bleeding indices (P > .05). Out of all transplanted patients, 42.8% were found to have the heterozygote genotype. This was reduced to 37.5% when individuals with GH were taken into account. However, when degree of GH was analyzed, those with severe GH were found to have the heterozygote genotype significantly more often (P < .05). ConclusionsThe MDR1 gene polymorphism is not associated with GH frequency, but may be associated with GH severity.
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subjectATP Binding Cassette Transporter, Sub-Family B–Genetics ; ATP-Binding Cassette, Sub-Family B, Member 1–Therapeutic Use ; Adolescent–Adverse Effects ; Adult–Diagnosis ; Aged–Epidemiology ; Calcium Channel Blockers–Genetics ; Cyclosporine–Adverse Effects ; Female–Adverse Effects ; Gene Frequency–Epidemiology ; Genetic Predisposition to Disease–Epidemiology ; Gingival Hyperplasia–Epidemiology ; Heterozygote–Epidemiology ; Humans–Epidemiology ; Immunosuppressive Agents–Epidemiology ; Kidney Transplantation–Epidemiology ; Male–Epidemiology ; Middle Aged–Epidemiology ; Phenotype–Epidemiology ; Polymorphism, Genetic–Epidemiology ; Risk Factors–Epidemiology ; Severity of Illness Index–Epidemiology ; Time Factors–Epidemiology ; Treatment Outcome–Epidemiology ; Turkey–Epidemiology ; Young Adult–Epidemiology ; Abcb1 Protein, Human ; ATP Binding Cassette Transporter, Sub-Family B ; ATP-Binding Cassette, Sub-Family B, Member 1 ; Calcium Channel Blockers ; Immunosuppressive Agents ; Cyclosporine;
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titleThe Role of MDR1 C3435T Gene Polymorphism on Gingival Hyperplasia in Turkish Renal Transplant Patients Treated With Cyclosporine in the Absence of Calcium Channel Blockers
descriptionObjectiveTo investigate the occurrence of MDR1 C3435T gene polymorphisms in the Turkish renal transplant patients treated with cyclosporine (CsA), and correlate these findings with prevalence and degree of gingival hyperplasia (GH). MethodsBefore to renal transplantation, dental treatment and oral hygiene education of 300 renal disease patients was completed. Peripheral blood samples were collected from 154 renal transplant recipients on CsA treatment without calcium channel blockers. MDR1 C3435T gene polymorphism and GH were analyzed at posttransplant month 6. ResultsNo difference was detected among groups for age, posttransplant period, creatine levels, serum concentration of CsA, or plaque and bleeding indices (P > .05). Out of all transplanted patients, 42.8% were found to have the heterozygote genotype. This was reduced to 37.5% when individuals with GH were taken into account. However, when degree of GH was analyzed, those with severe GH were found to have the heterozygote genotype significantly more often (P < .05). ConclusionsThe MDR1 gene polymorphism is not associated with GH frequency, but may be associated with GH severity.
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titleThe Role of MDR1 C3435T Gene Polymorphism on Gingival Hyperplasia in Turkish Renal Transplant Patients Treated With Cyclosporine in the Absence of Calcium Channel Blockers
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abstractObjectiveTo investigate the occurrence of MDR1 C3435T gene polymorphisms in the Turkish renal transplant patients treated with cyclosporine (CsA), and correlate these findings with prevalence and degree of gingival hyperplasia (GH). MethodsBefore to renal transplantation, dental treatment and oral hygiene education of 300 renal disease patients was completed. Peripheral blood samples were collected from 154 renal transplant recipients on CsA treatment without calcium channel blockers. MDR1 C3435T gene polymorphism and GH were analyzed at posttransplant month 6. ResultsNo difference was detected among groups for age, posttransplant period, creatine levels, serum concentration of CsA, or plaque and bleeding indices (P > .05). Out of all transplanted patients, 42.8% were found to have the heterozygote genotype. This was reduced to 37.5% when individuals with GH were taken into account. However, when degree of GH was analyzed, those with severe GH were found to have the heterozygote genotype significantly more often (P < .05). ConclusionsThe MDR1 gene polymorphism is not associated with GH frequency, but may be associated with GH severity.
pubElsevier Inc.
doi10.1016/j.transproceed.2012.12.007
eissn18732623