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Co-immunization with interlukin-18 enhances the protective efficacy of liposomes encapsulated recombinant Cu–Zn superoxide dismutase protein against Brucella abortus

Brucellosis is a worldwide zoonotic disease caused by Brucella abortus and a number of closely related species. Brucellosis has severe impact on the health and economic prosperity of the developing countries due to the persistent nature of infection and unavailability of effective control measures.... Full description

Journal Title: Vaccine 24 June 2011, Vol.29(29-30), pp.4720-4727
Main Author: Singha, Harisankar
Other Authors: Mallick, Amirul Islam , Jana, Chandrakanta , Fatima, Nishat , Owais, Mohammad , Chaudhuri, Pallab
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0264-410X ; DOI: 10.1016/j.vaccine.2011.04.088
Link: http://dx.doi.org/10.1016/j.vaccine.2011.04.088
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recordid: sciversesciencedirect_elsevierS0264-410X(11)00643-8
title: Co-immunization with interlukin-18 enhances the protective efficacy of liposomes encapsulated recombinant Cu–Zn superoxide dismutase protein against Brucella abortus
format: Article
creator:
  • Singha, Harisankar
  • Mallick, Amirul Islam
  • Jana, Chandrakanta
  • Fatima, Nishat
  • Owais, Mohammad
  • Chaudhuri, Pallab
subjects:
  • Brucella Abortus
  • Escheriosomes
  • Cu–Zn Superoxide Dismuatse (Sod)
  • Interleukin-18 (Il-18)
ispartof: Vaccine, 24 June 2011, Vol.29(29-30), pp.4720-4727
description: Brucellosis is a worldwide zoonotic disease caused by Brucella abortus and a number of closely related species. Brucellosis has severe impact on the health and economic prosperity of the developing countries due to the persistent nature of infection and unavailability of effective control measures. The Cu–Zn superoxide dismuatse (SOD) protein of Brucella have been extensively studied as a major antigen involved in bacterial evading mechanism of host defence. Being a critical pro-inflammatory cytokine interleukin-18 (IL-18) plays key role in induction of immune mediated protection against intracellular pathogens. In the present study, we aimed to investigate the immunogenic potential of fusogenic liposomes (escheriosomes) encapsulated recombinant Cu–Zn SOD (rSOD) protein alone or in combination with recombinant IL-18 (rIL-18). Escheriosomes encapsulated rSOD mediated immune responses were further increased upon co-immunization with rIL-18. Furthermore, immunization with escheriosomes encapsulated rSOD alone or in combination with rIL-18, increased resistance in mice against challenge with B. abortus 544.
language: eng
source:
identifier: ISSN: 0264-410X ; DOI: 10.1016/j.vaccine.2011.04.088
fulltext: fulltext
issn:
  • 0264410X
  • 0264-410X
url: Link


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titleCo-immunization with interlukin-18 enhances the protective efficacy of liposomes encapsulated recombinant Cu–Zn superoxide dismutase protein against Brucella abortus
creatorSingha, Harisankar ; Mallick, Amirul Islam ; Jana, Chandrakanta ; Fatima, Nishat ; Owais, Mohammad ; Chaudhuri, Pallab
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identifierISSN: 0264-410X ; DOI: 10.1016/j.vaccine.2011.04.088
subjectBrucella Abortus ; Escheriosomes ; Cu–Zn Superoxide Dismuatse (Sod) ; Interleukin-18 (Il-18)
descriptionBrucellosis is a worldwide zoonotic disease caused by Brucella abortus and a number of closely related species. Brucellosis has severe impact on the health and economic prosperity of the developing countries due to the persistent nature of infection and unavailability of effective control measures. The Cu–Zn superoxide dismuatse (SOD) protein of Brucella have been extensively studied as a major antigen involved in bacterial evading mechanism of host defence. Being a critical pro-inflammatory cytokine interleukin-18 (IL-18) plays key role in induction of immune mediated protection against intracellular pathogens. In the present study, we aimed to investigate the immunogenic potential of fusogenic liposomes (escheriosomes) encapsulated recombinant Cu–Zn SOD (rSOD) protein alone or in combination with recombinant IL-18 (rIL-18). Escheriosomes encapsulated rSOD mediated immune responses were further increased upon co-immunization with rIL-18. Furthermore, immunization with escheriosomes encapsulated rSOD alone or in combination with rIL-18, increased resistance in mice against challenge with B. abortus 544.
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abstractBrucellosis is a worldwide zoonotic disease caused by Brucella abortus and a number of closely related species. Brucellosis has severe impact on the health and economic prosperity of the developing countries due to the persistent nature of infection and unavailability of effective control measures. The Cu–Zn superoxide dismuatse (SOD) protein of Brucella have been extensively studied as a major antigen involved in bacterial evading mechanism of host defence. Being a critical pro-inflammatory cytokine interleukin-18 (IL-18) plays key role in induction of immune mediated protection against intracellular pathogens. In the present study, we aimed to investigate the immunogenic potential of fusogenic liposomes (escheriosomes) encapsulated recombinant Cu–Zn SOD (rSOD) protein alone or in combination with recombinant IL-18 (rIL-18). Escheriosomes encapsulated rSOD mediated immune responses were further increased upon co-immunization with rIL-18. Furthermore, immunization with escheriosomes encapsulated rSOD alone or in combination with rIL-18, increased resistance in mice against challenge with B. abortus 544.
pubElsevier Ltd
doi10.1016/j.vaccine.2011.04.088
eissn18732518
date2011-06-24