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Pituitary stalk Langerhans cell histiocytosis treated with CyberKnife radiosurgery

ObjectiveLangerhans cell histiocytosis (LCH) is a rare idiopathic disease that is characterized by clonal proliferation of Langerhans histiocytes in various parts of the body. These atypical cells have been found to infiltrate single or multiple organs, including bone, lungs, liver, spleen, lymph no... Full description

Journal Title: Clinical Neurology and Neurosurgery
Main Author: Hong, Wei-Chen
Other Authors: Murovic, Judith A. , Gibbs, Iris , Vogel, Hannes , Chang, Steven D.
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0303-8467 ; DOI: 10.1016/j.clineuro.2012.07.004
Link: http://dx.doi.org/10.1016/j.clineuro.2012.07.004
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recordid: sciversesciencedirect_elsevierS0303-8467(12)00360-5
title: Pituitary stalk Langerhans cell histiocytosis treated with CyberKnife radiosurgery
format: Article
creator:
  • Hong, Wei-Chen
  • Murovic, Judith A.
  • Gibbs, Iris
  • Vogel, Hannes
  • Chang, Steven D.
subjects:
  • Cyberknife Radiosurgery
  • Pituitary Stalk
  • Langerhans Cell Histiocytosis
  • Endocrine Deficiencies
  • Unifocal Disease
ispartof: Clinical Neurology and Neurosurgery
description: ObjectiveLangerhans cell histiocytosis (LCH) is a rare idiopathic disease that is characterized by clonal proliferation of Langerhans histiocytes in various parts of the body. These atypical cells have been found to infiltrate single or multiple organs, including bone, lungs, liver, spleen, lymph nodes, and skin. Central nervous system invasion in LCH patients has rarely been reported, especially in the adult population. Methods and resultsWe describe three histopathologically confirmed cases of adult LCH that involves both the pituitary stalk and hypothalamus, and report our limited experience of such cases in this location that has been treated with CyberKnife radio surgery. ConclusionThe treatment goal of controlling lesion growth is achieved by CyberKnife radiosurgery in this case series. All patients tolerated the treatment well without obvious complications.
language: eng
source:
identifier: ISSN: 0303-8467 ; DOI: 10.1016/j.clineuro.2012.07.004
fulltext: fulltext
issn:
  • 03038467
  • 0303-8467
url: Link


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titlePituitary stalk Langerhans cell histiocytosis treated with CyberKnife radiosurgery
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identifierISSN: 0303-8467 ; DOI: 10.1016/j.clineuro.2012.07.004
subjectCyberknife Radiosurgery ; Pituitary Stalk ; Langerhans Cell Histiocytosis ; Endocrine Deficiencies ; Unifocal Disease
descriptionObjectiveLangerhans cell histiocytosis (LCH) is a rare idiopathic disease that is characterized by clonal proliferation of Langerhans histiocytes in various parts of the body. These atypical cells have been found to infiltrate single or multiple organs, including bone, lungs, liver, spleen, lymph nodes, and skin. Central nervous system invasion in LCH patients has rarely been reported, especially in the adult population. Methods and resultsWe describe three histopathologically confirmed cases of adult LCH that involves both the pituitary stalk and hypothalamus, and report our limited experience of such cases in this location that has been treated with CyberKnife radio surgery. ConclusionThe treatment goal of controlling lesion growth is achieved by CyberKnife radiosurgery in this case series. All patients tolerated the treatment well without obvious complications.
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descriptionObjectiveLangerhans cell histiocytosis (LCH) is a rare idiopathic disease that is characterized by clonal proliferation of Langerhans histiocytes in various parts of the body. These atypical cells have been found to infiltrate single or multiple organs, including bone, lungs, liver, spleen, lymph nodes, and skin. Central nervous system invasion in LCH patients has rarely been reported, especially in the adult population. Methods and resultsWe describe three histopathologically confirmed cases of adult LCH that involves both the pituitary stalk and hypothalamus, and report our limited experience of such cases in this location that has been treated with CyberKnife radio surgery. ConclusionThe treatment goal of controlling lesion growth is achieved by CyberKnife radiosurgery in this case series. All patients tolerated the treatment well without obvious complications.
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abstractObjectiveLangerhans cell histiocytosis (LCH) is a rare idiopathic disease that is characterized by clonal proliferation of Langerhans histiocytes in various parts of the body. These atypical cells have been found to infiltrate single or multiple organs, including bone, lungs, liver, spleen, lymph nodes, and skin. Central nervous system invasion in LCH patients has rarely been reported, especially in the adult population. Methods and resultsWe describe three histopathologically confirmed cases of adult LCH that involves both the pituitary stalk and hypothalamus, and report our limited experience of such cases in this location that has been treated with CyberKnife radio surgery. ConclusionThe treatment goal of controlling lesion growth is achieved by CyberKnife radiosurgery in this case series. All patients tolerated the treatment well without obvious complications.
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