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Effects of N-terminal fragments of β-endorphin on feeding in chicks

It is known that N-terminal fragments of β-endorphin have biological activities, such as an antagonism effect of β-endorphin (1–31) on the secretion of hormones or thermoregulation in mammals. We studied the effects of the N-terminal fragments on feeding behavior in male broiler chicks. Intracerebro... Full description

Journal Title: Neuroscience Letters 12 September 2008, Vol.442(2), pp.140-142
Main Author: Yanagita, Kouichi
Other Authors: Shiraishi, Jun-Ichi , Fujita, Masanori , Bungo, Takashi
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0304-3940 ; DOI: 10.1016/j.neulet.2008.07.018
Link: http://dx.doi.org/10.1016/j.neulet.2008.07.018
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recordid: sciversesciencedirect_elsevierS0304-3940(08)00979-8
title: Effects of N-terminal fragments of β-endorphin on feeding in chicks
format: Article
creator:
  • Yanagita, Kouichi
  • Shiraishi, Jun-Ichi
  • Fujita, Masanori
  • Bungo, Takashi
subjects:
  • Β-Endorphin
  • N-Terminal Fragment
  • Feeding Behavior
  • Central Nervous System
  • Chick
ispartof: Neuroscience Letters, 12 September 2008, Vol.442(2), pp.140-142
description: It is known that N-terminal fragments of β-endorphin have biological activities, such as an antagonism effect of β-endorphin (1–31) on the secretion of hormones or thermoregulation in mammals. We studied the effects of the N-terminal fragments on feeding behavior in male broiler chicks. Intracerebroventricular administration of β-endorphin (1–27) (0.4nmol) stimulated feeding behavior compared with saline control during the 60-min experimental period. β-Endorphin (1–17) (2.0nmol) also increased food intake at 30min postinjection. Co-injection of either β-endorphin (1–27) or (1–17) was effective in reducing full-length β-endorphin-induced feeding in chicks. These data suggest that the N-terminal fragments of β-endorphin act as a partial agonist, and may regulate the activity of the central opioidergic system in chicks.
language: eng
source:
identifier: ISSN: 0304-3940 ; DOI: 10.1016/j.neulet.2008.07.018
fulltext: fulltext
issn:
  • 03043940
  • 0304-3940
url: Link


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titleEffects of N-terminal fragments of β-endorphin on feeding in chicks
creatorYanagita, Kouichi ; Shiraishi, Jun-Ichi ; Fujita, Masanori ; Bungo, Takashi
ispartofNeuroscience Letters, 12 September 2008, Vol.442(2), pp.140-142
identifierISSN: 0304-3940 ; DOI: 10.1016/j.neulet.2008.07.018
subjectΒ-Endorphin ; N-Terminal Fragment ; Feeding Behavior ; Central Nervous System ; Chick
descriptionIt is known that N-terminal fragments of β-endorphin have biological activities, such as an antagonism effect of β-endorphin (1–31) on the secretion of hormones or thermoregulation in mammals. We studied the effects of the N-terminal fragments on feeding behavior in male broiler chicks. Intracerebroventricular administration of β-endorphin (1–27) (0.4nmol) stimulated feeding behavior compared with saline control during the 60-min experimental period. β-Endorphin (1–17) (2.0nmol) also increased food intake at 30min postinjection. Co-injection of either β-endorphin (1–27) or (1–17) was effective in reducing full-length β-endorphin-induced feeding in chicks. These data suggest that the N-terminal fragments of β-endorphin act as a partial agonist, and may regulate the activity of the central opioidergic system in chicks.
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descriptionIt is known that N-terminal fragments of β-endorphin have biological activities, such as an antagonism effect of β-endorphin (1–31) on the secretion of hormones or thermoregulation in mammals. We studied the effects of the N-terminal fragments on feeding behavior in male broiler chicks. Intracerebroventricular administration of β-endorphin (1–27) (0.4nmol) stimulated feeding behavior compared with saline control during the 60-min experimental period. β-Endorphin (1–17) (2.0nmol) also increased food intake at 30min postinjection. Co-injection of either β-endorphin (1–27) or (1–17) was effective in reducing full-length β-endorphin-induced feeding in chicks. These data suggest that the N-terminal fragments of β-endorphin act as a partial agonist, and may regulate the activity of the central opioidergic system in chicks.
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abstractIt is known that N-terminal fragments of β-endorphin have biological activities, such as an antagonism effect of β-endorphin (1–31) on the secretion of hormones or thermoregulation in mammals. We studied the effects of the N-terminal fragments on feeding behavior in male broiler chicks. Intracerebroventricular administration of β-endorphin (1–27) (0.4nmol) stimulated feeding behavior compared with saline control during the 60-min experimental period. β-Endorphin (1–17) (2.0nmol) also increased food intake at 30min postinjection. Co-injection of either β-endorphin (1–27) or (1–17) was effective in reducing full-length β-endorphin-induced feeding in chicks. These data suggest that the N-terminal fragments of β-endorphin act as a partial agonist, and may regulate the activity of the central opioidergic system in chicks.
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date2008-09-12