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Construction of amphiphilic copolymer nanoparticles based on hyperbranched Poly (Amine-Ester) and 1,2-Dipalmitoyl-Sn-Glycero-3-Phosphoethanolamine as drug carriers for cancer therapy

Novel amphiphilic copolymer nanoparticles (HPAE-co-PLA-DPPE) composed of hyperbranched poly (amine-ester), polylactide and 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine (DPPE) segments were designed and synthesized that provided high encapsulation efficiency. These nanoparticles (NPs) were used t... Full description

Journal Title: Nanomedicine: Nanotechnology Biology, and Medicine, December 2011, Vol.7(6), pp.945-954
Main Author: Wu, Yan
Other Authors: Jiao, Fang , Han, Siyuan , Fan, Tengfei , Liu, Ying , Li, Wei , Hu, Liming , Zhao, Yuliang , Chen, Chunying
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1549-9634 ; DOI: 10.1016/j.nano.2011.04.010
Link: http://dx.doi.org/10.1016/j.nano.2011.04.010
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recordid: sciversesciencedirect_elsevierS1549-9634(11)00171-7
title: Construction of amphiphilic copolymer nanoparticles based on hyperbranched Poly (Amine-Ester) and 1,2-Dipalmitoyl-Sn-Glycero-3-Phosphoethanolamine as drug carriers for cancer therapy
format: Article
creator:
  • Wu, Yan
  • Jiao, Fang
  • Han, Siyuan
  • Fan, Tengfei
  • Liu, Ying
  • Li, Wei
  • Hu, Liming
  • Zhao, Yuliang
  • Chen, Chunying
subjects:
  • Drug Delivery
  • Controlled Drug Release
  • Hyperbranched Copolymer
  • Anti-Tumor Activity
  • Biocompatibility
ispartof: Nanomedicine: Nanotechnology, Biology, and Medicine, December 2011, Vol.7(6), pp.945-954
description: Novel amphiphilic copolymer nanoparticles (HPAE-co-PLA-DPPE) composed of hyperbranched poly (amine-ester), polylactide and 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine (DPPE) segments were designed and synthesized that provided high encapsulation efficiency. These nanoparticles (NPs) were used to encapsulate an antitumor model drug, doxorubicin (DOX). The resulting NPs exhibited high encapsulation efficiency to DOX under an appropriate condition. In vitro release experiments revealed that the release of DOX from NPs was faster at pH 4.5 than that at pH 7.4 or pH 6.0. Confocal microscopy observation indicated that the DOX-loaded NPs can enter cells and localize in lysosomes that can be released quickly into the cytoplasm. The DOX-loaded NPs showed comparable anticancer efficacy with the free drug both in vivo and in vitro. These results demonstrate a feasible application of the hyperbranched copolymer, HPAE-co-PLA-DPPE, as a promising nanocarrier for intracellular delivery of antitumor drugs. From the Clinical EditorIn this paper, the development of novel amphiphilic copolymer nanoparticles is discussed with the goal of establishing high encapsulation efficiency for chemotherapy drugs. A novel hyperbranched poly (amine-ester) derivative (HPAE-co-PLA-DPPE) was synthesized by conjugating DPPE onto HPAE-co-PLA. DOX molecules were efficiently loaded into the HPAE-co-PLA-DPPE nanoparticles and rapidly released under acidic conditions with higher anti-tumor ability both in vitro and in vivo. These data show that pH-responsive HPAE-co-PLA-DPPE conjugate nanoparticles efficiently deliver anticancer drugs.
language: eng
source:
identifier: ISSN: 1549-9634 ; DOI: 10.1016/j.nano.2011.04.010
fulltext: fulltext
issn:
  • 15499634
  • 1549-9634
url: Link


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titleConstruction of amphiphilic copolymer nanoparticles based on hyperbranched Poly (Amine-Ester) and 1,2-Dipalmitoyl-Sn-Glycero-3-Phosphoethanolamine as drug carriers for cancer therapy
creatorWu, Yan ; Jiao, Fang ; Han, Siyuan ; Fan, Tengfei ; Liu, Ying ; Li, Wei ; Hu, Liming ; Zhao, Yuliang ; Chen, Chunying
ispartofNanomedicine: Nanotechnology, Biology, and Medicine, December 2011, Vol.7(6), pp.945-954
identifierISSN: 1549-9634 ; DOI: 10.1016/j.nano.2011.04.010
subjectDrug Delivery ; Controlled Drug Release ; Hyperbranched Copolymer ; Anti-Tumor Activity ; Biocompatibility
descriptionNovel amphiphilic copolymer nanoparticles (HPAE-co-PLA-DPPE) composed of hyperbranched poly (amine-ester), polylactide and 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine (DPPE) segments were designed and synthesized that provided high encapsulation efficiency. These nanoparticles (NPs) were used to encapsulate an antitumor model drug, doxorubicin (DOX). The resulting NPs exhibited high encapsulation efficiency to DOX under an appropriate condition. In vitro release experiments revealed that the release of DOX from NPs was faster at pH 4.5 than that at pH 7.4 or pH 6.0. Confocal microscopy observation indicated that the DOX-loaded NPs can enter cells and localize in lysosomes that can be released quickly into the cytoplasm. The DOX-loaded NPs showed comparable anticancer efficacy with the free drug both in vivo and in vitro. These results demonstrate a feasible application of the hyperbranched copolymer, HPAE-co-PLA-DPPE, as a promising nanocarrier for intracellular delivery of antitumor drugs. From the Clinical EditorIn this paper, the development of novel amphiphilic copolymer nanoparticles is discussed with the goal of establishing high encapsulation efficiency for chemotherapy drugs. A novel hyperbranched poly (amine-ester) derivative (HPAE-co-PLA-DPPE) was synthesized by conjugating DPPE onto HPAE-co-PLA. DOX molecules were efficiently loaded into the HPAE-co-PLA-DPPE nanoparticles and rapidly released under acidic conditions with higher anti-tumor ability both in vitro and in vivo. These data show that pH-responsive HPAE-co-PLA-DPPE conjugate nanoparticles efficiently deliver anticancer drugs.
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descriptionNovel amphiphilic copolymer nanoparticles (HPAE-co-PLA-DPPE) composed of hyperbranched poly (amine-ester), polylactide and 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine (DPPE) segments were designed and synthesized that provided high encapsulation efficiency. These nanoparticles (NPs) were used to encapsulate an antitumor model drug, doxorubicin (DOX). The resulting NPs exhibited high encapsulation efficiency to DOX under an appropriate condition. In vitro release experiments revealed that the release of DOX from NPs was faster at pH 4.5 than that at pH 7.4 or pH 6.0. Confocal microscopy observation indicated that the DOX-loaded NPs can enter cells and localize in lysosomes that can be released quickly into the cytoplasm. The DOX-loaded NPs showed comparable anticancer efficacy with the free drug both in vivo and in vitro. These results demonstrate a feasible application of the hyperbranched copolymer, HPAE-co-PLA-DPPE, as a promising nanocarrier for intracellular delivery of antitumor drugs. From the Clinical EditorIn this paper, the development of novel amphiphilic copolymer nanoparticles is discussed with the goal of establishing high encapsulation efficiency for chemotherapy drugs. A novel hyperbranched poly (amine-ester) derivative (HPAE-co-PLA-DPPE) was synthesized by conjugating DPPE onto HPAE-co-PLA. DOX molecules were efficiently loaded into the HPAE-co-PLA-DPPE nanoparticles and rapidly released under acidic conditions with higher anti-tumor ability both in vitro and in vivo. These data show that pH-responsive HPAE-co-PLA-DPPE conjugate nanoparticles efficiently deliver anticancer drugs.
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abstractNovel amphiphilic copolymer nanoparticles (HPAE-co-PLA-DPPE) composed of hyperbranched poly (amine-ester), polylactide and 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine (DPPE) segments were designed and synthesized that provided high encapsulation efficiency. These nanoparticles (NPs) were used to encapsulate an antitumor model drug, doxorubicin (DOX). The resulting NPs exhibited high encapsulation efficiency to DOX under an appropriate condition. In vitro release experiments revealed that the release of DOX from NPs was faster at pH 4.5 than that at pH 7.4 or pH 6.0. Confocal microscopy observation indicated that the DOX-loaded NPs can enter cells and localize in lysosomes that can be released quickly into the cytoplasm. The DOX-loaded NPs showed comparable anticancer efficacy with the free drug both in vivo and in vitro. These results demonstrate a feasible application of the hyperbranched copolymer, HPAE-co-PLA-DPPE, as a promising nanocarrier for intracellular delivery of antitumor drugs. From the Clinical EditorIn this paper, the development of novel amphiphilic copolymer nanoparticles is discussed with the goal of establishing high encapsulation efficiency for chemotherapy drugs. A novel hyperbranched poly (amine-ester) derivative (HPAE-co-PLA-DPPE) was synthesized by conjugating DPPE onto HPAE-co-PLA. DOX molecules were efficiently loaded into the HPAE-co-PLA-DPPE nanoparticles and rapidly released under acidic conditions with higher anti-tumor ability both in vitro and in vivo. These data show that pH-responsive HPAE-co-PLA-DPPE conjugate nanoparticles efficiently deliver anticancer drugs.
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