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Effect of topiramate on interleukin 6 expression in the hippocampus of amygdala-kindled epileptic rats

The objective of this study was to analyze the changes in expression and the possible functions of interleukin-6 (IL-6) in electrical kindling of the basolateral amygdala (BLA) in epileptic rats. Bipolar electrodes were implanted into the BLA of Sprague-Dawley rats, and the rats were then subjected... Full description

Journal Title: Experimental and Therapeutic Medicine 1/2014, Vol.7(1), pp.223-227
Main Author: Ye, Fei
Other Authors: Chen, Xu-Qin , Bao, Guan-Shui , Hua, Yin , Wang, Zhe-Dong , Bao, Yi-Chuan
Format: Electronic Article Electronic Article
Language: English
Subjects:
Rat
ID: ISSN: 1792-0981 ; E-ISSN: 1792-1015 ; DOI: 10.3892/etm.2013.1396
Link: http://www.spandidos-publications.com/etm/7/1/223
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recordid: spandido10.3892/etm.2013.1396
title: Effect of topiramate on interleukin 6 expression in the hippocampus of amygdala-kindled epileptic rats
format: Article
creator:
  • Ye, Fei
  • Chen, Xu-Qin
  • Bao, Guan-Shui
  • Hua, Yin
  • Wang, Zhe-Dong
  • Bao, Yi-Chuan
subjects:
  • Interleukin-6
  • Epilepsy
  • Kindling
  • Rat
  • Basolateral Amygdale
  • Topiramate
ispartof: Experimental and Therapeutic Medicine, 1/2014, Vol.7(1), pp.223-227
description: The objective of this study was to analyze the changes in expression and the possible functions of interleukin-6 (IL-6) in electrical kindling of the basolateral amygdala (BLA) in epileptic rats. Bipolar electrodes were implanted into the BLA of Sprague-Dawley rats, and the rats were then subjected to chronic electrical stimulation through the electrodes to induce kindling. The seizure characteristics and behavioral changes of the rats were observed, and electroencephalograms were recorded during and following kindling. The IL-6 mRNA expression in the hippocampi of the rats was analyzed using semi-quantitative reverse transcription-polymerase chain reaction, and control and topiramate (TPM)-treated groups were compared. The mean time-period required for kindling was 13.50±3.99 days, and the afterdischarge duration (ADD) measured between 21,450 and 119,720 msec. The expression of IL-6 mRNA was significantly upregulated in the kindled rats. TPM was able to depress the seizures and decrease the IL-6 level in the kindled rats. In conclusion, IL-6 mRNA was upregulated in the hippocampi of epileptic rats, and IL-6 may have participated in the process of kindling.
language: eng
source:
identifier: ISSN: 1792-0981 ; E-ISSN: 1792-1015 ; DOI: 10.3892/etm.2013.1396
fulltext: fulltext
issn:
  • 1792-0981
  • 17920981
  • 1792-1015
  • 17921015
url: Link


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titleEffect of topiramate on interleukin 6 expression in the hippocampus of amygdala-kindled epileptic rats
creatorYe, Fei ; Chen, Xu-Qin ; Bao, Guan-Shui ; Hua, Yin ; Wang, Zhe-Dong ; Bao, Yi-Chuan
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subjectInterleukin-6 ; Epilepsy ; Kindling ; Rat ; Basolateral Amygdale ; Topiramate
descriptionThe objective of this study was to analyze the changes in expression and the possible functions of interleukin-6 (IL-6) in electrical kindling of the basolateral amygdala (BLA) in epileptic rats. Bipolar electrodes were implanted into the BLA of Sprague-Dawley rats, and the rats were then subjected to chronic electrical stimulation through the electrodes to induce kindling. The seizure characteristics and behavioral changes of the rats were observed, and electroencephalograms were recorded during and following kindling. The IL-6 mRNA expression in the hippocampi of the rats was analyzed using semi-quantitative reverse transcription-polymerase chain reaction, and control and topiramate (TPM)-treated groups were compared. The mean time-period required for kindling was 13.50±3.99 days, and the afterdischarge duration (ADD) measured between 21,450 and 119,720 msec. The expression of IL-6 mRNA was significantly upregulated in the kindled rats. TPM was able to depress the seizures and decrease the IL-6 level in the kindled rats. In conclusion, IL-6 mRNA was upregulated in the hippocampi of epileptic rats, and IL-6 may have participated in the process of kindling.
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descriptionThe objective of this study was to analyze the changes in expression and the possible functions of interleukin-6 (IL-6) in electrical kindling of the basolateral amygdala (BLA) in epileptic rats. Bipolar electrodes were implanted into the BLA of Sprague-Dawley rats, and the rats were then subjected to chronic electrical stimulation through the electrodes to induce kindling. The seizure characteristics and behavioral changes of the rats were observed, and electroencephalograms were recorded during and following kindling. The IL-6 mRNA expression in the hippocampi of the rats was analyzed using semi-quantitative reverse transcription-polymerase chain reaction, and control and topiramate (TPM)-treated groups were compared. The mean time-period required for kindling was 13.50±3.99 days, and the afterdischarge duration (ADD) measured between 21,450 and 119,720 msec. The expression of IL-6 mRNA was significantly upregulated in the kindled rats. TPM was able to depress the seizures and decrease the IL-6 level in the kindled rats. In conclusion, IL-6 mRNA was upregulated in the hippocampi of epileptic rats, and IL-6 may have participated in the process of kindling.
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abstractThe objective of this study was to analyze the changes in expression and the possible functions of interleukin-6 (IL-6) in electrical kindling of the basolateral amygdala (BLA) in epileptic rats. Bipolar electrodes were implanted into the BLA of Sprague-Dawley rats, and the rats were then subjected to chronic electrical stimulation through the electrodes to induce kindling. The seizure characteristics and behavioral changes of the rats were observed, and electroencephalograms were recorded during and following kindling. The IL-6 mRNA expression in the hippocampi of the rats was analyzed using semi-quantitative reverse transcription-polymerase chain reaction, and control and topiramate (TPM)-treated groups were compared. The mean time-period required for kindling was 13.50±3.99 days, and the afterdischarge duration (ADD) measured between 21,450 and 119,720 msec. The expression of IL-6 mRNA was significantly upregulated in the kindled rats. TPM was able to depress the seizures and decrease the IL-6 level in the kindled rats. In conclusion, IL-6 mRNA was upregulated in the hippocampi of epileptic rats, and IL-6 may have participated in the process of kindling.
pubD.A. Spandidos
doi10.3892/etm.2013.1396