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Butein induces cell apoptosis and inhibition of cyclooxygenase-2 expression in A549 lung cancer cells

Butein is a flavonoid isolated from the bark of Rhus verniciflua Stokes and the flowers of Butea monosperma , and is known to be a potential therapeutic drug for treating inflammation and cancer. Cyclooxygenase (COX) converts arachidonic acid to prostanoids, and increased expression of its isoform,... Full description

Journal Title: Molecular Medicine Reports 2/2014, Vol.9(2), pp.763-767
Main Author: Li, Yang
Other Authors: Ma, Chengyuan , Qian, Ming , Wen, Zhongmei , Jing, Hongyu , Qian, Donghua
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1791-2997 ; E-ISSN: 1791-3004 ; DOI: 10.3892/mmr.2013.1850
Link: http://www.spandidos-publications.com/molecular medicine reports/9/2/763
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recordid: spandido10.3892/mmr.2013.1850
title: Butein induces cell apoptosis and inhibition of cyclooxygenase-2 expression in A549 lung cancer cells
format: Article
creator:
  • Li, Yang
  • Ma, Chengyuan
  • Qian, Ming
  • Wen, Zhongmei
  • Jing, Hongyu
  • Qian, Donghua
subjects:
  • Butein
  • Lung Cancer
  • Cyclooxygenase-2
  • A549
ispartof: Molecular Medicine Reports, 2/2014, Vol.9(2), pp.763-767
description: Butein is a flavonoid isolated from the bark of Rhus verniciflua Stokes and the flowers of Butea monosperma , and is known to be a potential therapeutic drug for treating inflammation and cancer. Cyclooxygenase (COX) converts arachidonic acid to prostanoids, and increased expression of its isoform, COX-2, has been observed in lung cancer tissue. The aim of the present study was to investigate expression alteration of COX-2 in A549 lung cancer cells following butein treatment at the mRNA and protein levels by quantitative polymerase chain reaction and western blotting, respectively. It was observed that COX-2 mRNA and protein levels were significantly downregulated in the butein treatment group in comparison with the control group (P
language: eng
source:
identifier: ISSN: 1791-2997 ; E-ISSN: 1791-3004 ; DOI: 10.3892/mmr.2013.1850
fulltext: fulltext
issn:
  • 1791-2997
  • 17912997
  • 1791-3004
  • 17913004
url: Link


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titleButein induces cell apoptosis and inhibition of cyclooxygenase-2 expression in A549 lung cancer cells
creatorLi, Yang ; Ma, Chengyuan ; Qian, Ming ; Wen, Zhongmei ; Jing, Hongyu ; Qian, Donghua
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subjectButein ; Lung Cancer ; Cyclooxygenase-2 ; A549
descriptionButein is a flavonoid isolated from the bark of Rhus verniciflua Stokes and the flowers of Butea monosperma , and is known to be a potential therapeutic drug for treating inflammation and cancer. Cyclooxygenase (COX) converts arachidonic acid to prostanoids, and increased expression of its isoform, COX-2, has been observed in lung cancer tissue. The aim of the present study was to investigate expression alteration of COX-2 in A549 lung cancer cells following butein treatment at the mRNA and protein levels by quantitative polymerase chain reaction and western blotting, respectively. It was observed that COX-2 mRNA and protein levels were significantly downregulated in the butein treatment group in comparison with the control group (P<0.05). In addition, the effects of butein on proliferation and apoptosis were evaluated. The data demonstrated that butein induces cell-cycle arrest and apoptosis in human lung cancer cells. These results indicated that butein may be a promising candidate drug for lung cancer treatment.
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titleButein induces cell apoptosis and inhibition of cyclooxygenase-2 expression in A549 lung cancer cells
descriptionButein is a flavonoid isolated from the bark of Rhus verniciflua Stokes and the flowers of Butea monosperma , and is known to be a potential therapeutic drug for treating inflammation and cancer. Cyclooxygenase (COX) converts arachidonic acid to prostanoids, and increased expression of its isoform, COX-2, has been observed in lung cancer tissue. The aim of the present study was to investigate expression alteration of COX-2 in A549 lung cancer cells following butein treatment at the mRNA and protein levels by quantitative polymerase chain reaction and western blotting, respectively. It was observed that COX-2 mRNA and protein levels were significantly downregulated in the butein treatment group in comparison with the control group (P<0.05). In addition, the effects of butein on proliferation and apoptosis were evaluated. The data demonstrated that butein induces cell-cycle arrest and apoptosis in human lung cancer cells. These results indicated that butein may be a promising candidate drug for lung cancer treatment.
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abstractButein is a flavonoid isolated from the bark of Rhus verniciflua Stokes and the flowers of Butea monosperma , and is known to be a potential therapeutic drug for treating inflammation and cancer. Cyclooxygenase (COX) converts arachidonic acid to prostanoids, and increased expression of its isoform, COX-2, has been observed in lung cancer tissue. The aim of the present study was to investigate expression alteration of COX-2 in A549 lung cancer cells following butein treatment at the mRNA and protein levels by quantitative polymerase chain reaction and western blotting, respectively. It was observed that COX-2 mRNA and protein levels were significantly downregulated in the butein treatment group in comparison with the control group (P<0.05). In addition, the effects of butein on proliferation and apoptosis were evaluated. The data demonstrated that butein induces cell-cycle arrest and apoptosis in human lung cancer cells. These results indicated that butein may be a promising candidate drug for lung cancer treatment.
pubD.A. Spandidos
doi10.3892/mmr.2013.1850