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Antitumor activity of fucoidan in anaplastic thyroid cancer via apoptosis and anti-angiogenesis

The present study demonstrated the effect of fucoidan, isolated from Fucus vesiculosus , on cell growth and apoptosis in anaplastic thyroid cancer cells. The cell viability was analyzed using a Cell Counting Kit-8 cell proliferation kit. Diamidino-2-phenylindole and terminal deoxynucleotidyl transfe... Full description

Journal Title: Molecular Medicine Reports 05/2017, Vol.15(5), pp.2620-2624
Main Author: Shen, Hong-Yan
Other Authors: Li, Lan-Zhen , Xue, Ke-Cheng , Hu, Dan-Dan , Gao, Yu-Jun
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1791-2997 ; E-ISSN: 1791-3004 ; DOI: 10.3892/mmr.2017.6338
Link: http://www.spandidos-publications.com/molecular medicine reports/15/5/2620
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recordid: spandido10.3892/mmr.2017.6338
title: Antitumor activity of fucoidan in anaplastic thyroid cancer via apoptosis and anti-angiogenesis
format: Article
creator:
  • Shen, Hong-Yan
  • Li, Lan-Zhen
  • Xue, Ke-Cheng
  • Hu, Dan-Dan
  • Gao, Yu-Jun
subjects:
  • Anaplastic Thyroid Cancer
  • Apoptosis
  • Cell Growth
  • Inhibition
  • Migration
ispartof: Molecular Medicine Reports, 05/2017, Vol.15(5), pp.2620-2624
description: The present study demonstrated the effect of fucoidan, isolated from Fucus vesiculosus , on cell growth and apoptosis in anaplastic thyroid cancer cells. The cell viability was analyzed using a Cell Counting Kit-8 cell proliferation kit. Diamidino-2-phenylindole and terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling assays were used to examine the apoptotic effect of fucoidan, which revealed the presence of apoptotic bodies and DNA fragmentation. Fucoidan inhibited the growth of FTC133 and TPC1 ATC cells in a dose-dependent manner. It also induced the apoptosis of FTC133 cells by promoting the expression levels of cleaved poly ADP-ribose polymerase and caspase-3. Significant decreases in the levels expression of hypoxia-inducible factor 1α and vascular endothelial growth factor were observed in the FTC133 cells following treatment of the cells with fucoidan. In addition, inhibition in tube formation and the migration of FTC133 cells were observed in the cells treated with fucoidan, compared with the cells in the control group. Therefore, fucoidan inhibited cell growth, induced apoptosis and suppressed angiogenesis in the thyroid cancer cells.
language: eng
source:
identifier: ISSN: 1791-2997 ; E-ISSN: 1791-3004 ; DOI: 10.3892/mmr.2017.6338
fulltext: fulltext
issn:
  • 1791-2997
  • 17912997
  • 1791-3004
  • 17913004
url: Link


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titleAntitumor activity of fucoidan in anaplastic thyroid cancer via apoptosis and anti-angiogenesis
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subjectAnaplastic Thyroid Cancer ; Apoptosis ; Cell Growth ; Inhibition ; Migration
descriptionThe present study demonstrated the effect of fucoidan, isolated from Fucus vesiculosus , on cell growth and apoptosis in anaplastic thyroid cancer cells. The cell viability was analyzed using a Cell Counting Kit-8 cell proliferation kit. Diamidino-2-phenylindole and terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling assays were used to examine the apoptotic effect of fucoidan, which revealed the presence of apoptotic bodies and DNA fragmentation. Fucoidan inhibited the growth of FTC133 and TPC1 ATC cells in a dose-dependent manner. It also induced the apoptosis of FTC133 cells by promoting the expression levels of cleaved poly ADP-ribose polymerase and caspase-3. Significant decreases in the levels expression of hypoxia-inducible factor 1α and vascular endothelial growth factor were observed in the FTC133 cells following treatment of the cells with fucoidan. In addition, inhibition in tube formation and the migration of FTC133 cells were observed in the cells treated with fucoidan, compared with the cells in the control group. Therefore, fucoidan inhibited cell growth, induced apoptosis and suppressed angiogenesis in the thyroid cancer cells.
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descriptionThe present study demonstrated the effect of fucoidan, isolated from Fucus vesiculosus , on cell growth and apoptosis in anaplastic thyroid cancer cells. The cell viability was analyzed using a Cell Counting Kit-8 cell proliferation kit. Diamidino-2-phenylindole and terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling assays were used to examine the apoptotic effect of fucoidan, which revealed the presence of apoptotic bodies and DNA fragmentation. Fucoidan inhibited the growth of FTC133 and TPC1 ATC cells in a dose-dependent manner. It also induced the apoptosis of FTC133 cells by promoting the expression levels of cleaved poly ADP-ribose polymerase and caspase-3. Significant decreases in the levels expression of hypoxia-inducible factor 1α and vascular endothelial growth factor were observed in the FTC133 cells following treatment of the cells with fucoidan. In addition, inhibition in tube formation and the migration of FTC133 cells were observed in the cells treated with fucoidan, compared with the cells in the control group. Therefore, fucoidan inhibited cell growth, induced apoptosis and suppressed angiogenesis in the thyroid cancer cells.
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abstractThe present study demonstrated the effect of fucoidan, isolated from Fucus vesiculosus , on cell growth and apoptosis in anaplastic thyroid cancer cells. The cell viability was analyzed using a Cell Counting Kit-8 cell proliferation kit. Diamidino-2-phenylindole and terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling assays were used to examine the apoptotic effect of fucoidan, which revealed the presence of apoptotic bodies and DNA fragmentation. Fucoidan inhibited the growth of FTC133 and TPC1 ATC cells in a dose-dependent manner. It also induced the apoptosis of FTC133 cells by promoting the expression levels of cleaved poly ADP-ribose polymerase and caspase-3. Significant decreases in the levels expression of hypoxia-inducible factor 1α and vascular endothelial growth factor were observed in the FTC133 cells following treatment of the cells with fucoidan. In addition, inhibition in tube formation and the migration of FTC133 cells were observed in the cells treated with fucoidan, compared with the cells in the control group. Therefore, fucoidan inhibited cell growth, induced apoptosis and suppressed angiogenesis in the thyroid cancer cells.
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date2017-05