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Role of Annexin A2 in the EGF-induced epithelial-mesenchymal transition in human CaSki cells

The epidermal growth factor receptor (EGF-R) signaling pathway is thought to have an important role in the development and progression of several carcinomas, as it is associated with cell proliferation, differentiation and migration. Activation of EGF-R signaling regulates epithelial-mesenchymal tra... Full description

Journal Title: Oncology Letters 01/2017, Vol.13(1), pp.377-383
Main Author: Cui, Lei
Other Authors: Song, Jian , Wu, Liting , Cheng, Luhui , Chen, Aijun , Wang, Yanlin , Huang, Yingdi , Huang, Liming
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1792-1074 ; E-ISSN: 1792-1082 ; DOI: 10.3892/ol.2016.5406
Link: http://www.spandidos-publications.com/ol/13/1/377
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recordid: spandido10.3892/ol.2016.5406
title: Role of Annexin A2 in the EGF-induced epithelial-mesenchymal transition in human CaSki cells
format: Article
creator:
  • Cui, Lei
  • Song, Jian
  • Wu, Liting
  • Cheng, Luhui
  • Chen, Aijun
  • Wang, Yanlin
  • Huang, Yingdi
  • Huang, Liming
subjects:
  • Annexin A2
  • Epithelial-Mesenchymal Transition
  • Epidermal Growth Factor Receptor Signaling
  • Cell Proliferation
ispartof: Oncology Letters, 01/2017, Vol.13(1), pp.377-383
description: The epidermal growth factor receptor (EGF-R) signaling pathway is thought to have an important role in the development and progression of several carcinomas, as it is associated with cell proliferation, differentiation and migration. Activation of EGF-R signaling regulates epithelial-mesenchymal transition (EMT)-associated invasion and migration in normal and malignant epithelial cells. However, the specific mechanisms have not yet been fully elucidated. The present study utilized wound healing assays, western blotting, flow cytometry and MTT assays to demonstrate that Annexin A2 (ANXA2) is a key regulatory factor in EGF-induced EMT in CaSki cervical cancer cells. Moreover, the increased expression levels of ANXA2 promoted cell viability and migration in human CaSki cells. It was also found that silencing ANXA2 partially reverses EGF-induced EMT and inhibits cell viability and migration in CaSki cells. These findings suggest that ANXA2 is a key regulator of EGF-induced EMT in CaSki cervical cancer cells.
language: eng
source:
identifier: ISSN: 1792-1074 ; E-ISSN: 1792-1082 ; DOI: 10.3892/ol.2016.5406
fulltext: fulltext
issn:
  • 1792-1074
  • 17921074
  • 1792-1082
  • 17921082
url: Link


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titleRole of Annexin A2 in the EGF-induced epithelial-mesenchymal transition in human CaSki cells
creatorCui, Lei ; Song, Jian ; Wu, Liting ; Cheng, Luhui ; Chen, Aijun ; Wang, Yanlin ; Huang, Yingdi ; Huang, Liming
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subjectAnnexin A2 ; Epithelial-Mesenchymal Transition ; Epidermal Growth Factor Receptor Signaling ; Cell Proliferation
descriptionThe epidermal growth factor receptor (EGF-R) signaling pathway is thought to have an important role in the development and progression of several carcinomas, as it is associated with cell proliferation, differentiation and migration. Activation of EGF-R signaling regulates epithelial-mesenchymal transition (EMT)-associated invasion and migration in normal and malignant epithelial cells. However, the specific mechanisms have not yet been fully elucidated. The present study utilized wound healing assays, western blotting, flow cytometry and MTT assays to demonstrate that Annexin A2 (ANXA2) is a key regulatory factor in EGF-induced EMT in CaSki cervical cancer cells. Moreover, the increased expression levels of ANXA2 promoted cell viability and migration in human CaSki cells. It was also found that silencing ANXA2 partially reverses EGF-induced EMT and inhibits cell viability and migration in CaSki cells. These findings suggest that ANXA2 is a key regulator of EGF-induced EMT in CaSki cervical cancer cells.
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descriptionThe epidermal growth factor receptor (EGF-R) signaling pathway is thought to have an important role in the development and progression of several carcinomas, as it is associated with cell proliferation, differentiation and migration. Activation of EGF-R signaling regulates epithelial-mesenchymal transition (EMT)-associated invasion and migration in normal and malignant epithelial cells. However, the specific mechanisms have not yet been fully elucidated. The present study utilized wound healing assays, western blotting, flow cytometry and MTT assays to demonstrate that Annexin A2 (ANXA2) is a key regulatory factor in EGF-induced EMT in CaSki cervical cancer cells. Moreover, the increased expression levels of ANXA2 promoted cell viability and migration in human CaSki cells. It was also found that silencing ANXA2 partially reverses EGF-induced EMT and inhibits cell viability and migration in CaSki cells. These findings suggest that ANXA2 is a key regulator of EGF-induced EMT in CaSki cervical cancer cells.
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abstractThe epidermal growth factor receptor (EGF-R) signaling pathway is thought to have an important role in the development and progression of several carcinomas, as it is associated with cell proliferation, differentiation and migration. Activation of EGF-R signaling regulates epithelial-mesenchymal transition (EMT)-associated invasion and migration in normal and malignant epithelial cells. However, the specific mechanisms have not yet been fully elucidated. The present study utilized wound healing assays, western blotting, flow cytometry and MTT assays to demonstrate that Annexin A2 (ANXA2) is a key regulatory factor in EGF-induced EMT in CaSki cervical cancer cells. Moreover, the increased expression levels of ANXA2 promoted cell viability and migration in human CaSki cells. It was also found that silencing ANXA2 partially reverses EGF-induced EMT and inhibits cell viability and migration in CaSki cells. These findings suggest that ANXA2 is a key regulator of EGF-induced EMT in CaSki cervical cancer cells.
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