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Role of Annexin A2 in the EGF-induced epithelial-mesenchymal transition in human CaSki cells

The epidermal growth factor receptor (EGF-R) signaling pathway is thought to have an important role in the development and progression of several carcinomas, as it is associated with cell proliferation, differentiation and migration. Activation of EGF-R signaling regulates epithelial-mesenchymal tra... Full description

Journal Title: Oncology letters 2017-01, Vol.13 (1), p.377-383
Main Author: Cui, Lei
Other Authors: Song, Jian , Wu, Liting , Cheng, Luhui , Chen, Aijun , Wang, Yanlin , Huang, Yingdi , Huang, Liming
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Greece: D.A. Spandidos
ID: ISSN: 1792-1074
Link: https://www.ncbi.nlm.nih.gov/pubmed/28123570
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recordid: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5244908
title: Role of Annexin A2 in the EGF-induced epithelial-mesenchymal transition in human CaSki cells
format: Article
creator:
  • Cui, Lei
  • Song, Jian
  • Wu, Liting
  • Cheng, Luhui
  • Chen, Aijun
  • Wang, Yanlin
  • Huang, Yingdi
  • Huang, Liming
subjects:
  • Annexin A2
  • Annexins
  • Articles
  • Biotechnology
  • Care and treatment
  • Cell adhesion & migration
  • Cell cycle
  • Cell growth
  • cell proliferation
  • Cervical cancer
  • Development and progression
  • Epidermal growth factor
  • epidermal growth factor receptor signaling
  • epithelial-mesenchymal transition
  • Flow cytometry
  • Gene expression
  • Genetic aspects
  • Growth rate
  • Health aspects
  • Kinases
  • Metastasis
  • Proteins
  • Signal transduction
  • Statistical analysis
  • Wound healing
ispartof: Oncology letters, 2017-01, Vol.13 (1), p.377-383
description: The epidermal growth factor receptor (EGF-R) signaling pathway is thought to have an important role in the development and progression of several carcinomas, as it is associated with cell proliferation, differentiation and migration. Activation of EGF-R signaling regulates epithelial-mesenchymal transition (EMT)-associated invasion and migration in normal and malignant epithelial cells. However, the specific mechanisms have not yet been fully elucidated. The present study utilized wound healing assays, western blotting, flow cytometry and MTT assays to demonstrate that Annexin A2 (ANXA2) is a key regulatory factor in EGF-induced EMT in CaSki cervical cancer cells. Moreover, the increased expression levels of ANXA2 promoted cell viability and migration in human CaSki cells. It was also found that silencing ANXA2 partially reverses EGF-induced EMT and inhibits cell viability and migration in CaSki cells. These findings suggest that ANXA2 is a key regulator of EGF-induced EMT in CaSki cervical cancer cells.
language: eng
source:
identifier: ISSN: 1792-1074
fulltext: no_fulltext
issn:
  • 1792-1074
  • 1792-1082
url: Link


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descriptionThe epidermal growth factor receptor (EGF-R) signaling pathway is thought to have an important role in the development and progression of several carcinomas, as it is associated with cell proliferation, differentiation and migration. Activation of EGF-R signaling regulates epithelial-mesenchymal transition (EMT)-associated invasion and migration in normal and malignant epithelial cells. However, the specific mechanisms have not yet been fully elucidated. The present study utilized wound healing assays, western blotting, flow cytometry and MTT assays to demonstrate that Annexin A2 (ANXA2) is a key regulatory factor in EGF-induced EMT in CaSki cervical cancer cells. Moreover, the increased expression levels of ANXA2 promoted cell viability and migration in human CaSki cells. It was also found that silencing ANXA2 partially reverses EGF-induced EMT and inhibits cell viability and migration in CaSki cells. These findings suggest that ANXA2 is a key regulator of EGF-induced EMT in CaSki cervical cancer cells.
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subjectAnnexin A2 ; Annexins ; Articles ; Biotechnology ; Care and treatment ; Cell adhesion & migration ; Cell cycle ; Cell growth ; cell proliferation ; Cervical cancer ; Development and progression ; Epidermal growth factor ; epidermal growth factor receptor signaling ; epithelial-mesenchymal transition ; Flow cytometry ; Gene expression ; Genetic aspects ; Growth rate ; Health aspects ; Kinases ; Metastasis ; Proteins ; Signal transduction ; Statistical analysis ; Wound healing
ispartofOncology letters, 2017-01, Vol.13 (1), p.377-383
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descriptionThe epidermal growth factor receptor (EGF-R) signaling pathway is thought to have an important role in the development and progression of several carcinomas, as it is associated with cell proliferation, differentiation and migration. Activation of EGF-R signaling regulates epithelial-mesenchymal transition (EMT)-associated invasion and migration in normal and malignant epithelial cells. However, the specific mechanisms have not yet been fully elucidated. The present study utilized wound healing assays, western blotting, flow cytometry and MTT assays to demonstrate that Annexin A2 (ANXA2) is a key regulatory factor in EGF-induced EMT in CaSki cervical cancer cells. Moreover, the increased expression levels of ANXA2 promoted cell viability and migration in human CaSki cells. It was also found that silencing ANXA2 partially reverses EGF-induced EMT and inhibits cell viability and migration in CaSki cells. These findings suggest that ANXA2 is a key regulator of EGF-induced EMT in CaSki cervical cancer cells.
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abstractThe epidermal growth factor receptor (EGF-R) signaling pathway is thought to have an important role in the development and progression of several carcinomas, as it is associated with cell proliferation, differentiation and migration. Activation of EGF-R signaling regulates epithelial-mesenchymal transition (EMT)-associated invasion and migration in normal and malignant epithelial cells. However, the specific mechanisms have not yet been fully elucidated. The present study utilized wound healing assays, western blotting, flow cytometry and MTT assays to demonstrate that Annexin A2 (ANXA2) is a key regulatory factor in EGF-induced EMT in CaSki cervical cancer cells. Moreover, the increased expression levels of ANXA2 promoted cell viability and migration in human CaSki cells. It was also found that silencing ANXA2 partially reverses EGF-induced EMT and inhibits cell viability and migration in CaSki cells. These findings suggest that ANXA2 is a key regulator of EGF-induced EMT in CaSki cervical cancer cells.
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