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Biosynthesis and roles of phospholipids in mitochondrial fusion, division and mitophagy

Mitochondria move, fuse and divide in cells. The dynamic behavior of mitochondria is central to the control of their structure and function. Three conserved mitochondrial dynamin-related GTPases (i.e., mitofusin, Opa1 and Drp1 in mammals and Fzo1, Mgm1 and Dnm1 in yeast) mediate mitochondrial fusion... Full description

Journal Title: Cellular and Molecular Life Sciences 2014, Vol.71(19), pp.3767-3778
Main Author: Zhang, Qiang
Other Authors: Tamura, Yasushi , Roy, Madhuparna , Adachi, Yoshihiro , Iijima, Miho , Sesaki, Hiromi
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1420-682X ; E-ISSN: 1420-9071 ; DOI: 10.1007/s00018-014-1648-6
Link: http://dx.doi.org/10.1007/s00018-014-1648-6
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recordid: springer_jour10.1007/s00018-014-1648-6
title: Biosynthesis and roles of phospholipids in mitochondrial fusion, division and mitophagy
format: Article
creator:
  • Zhang, Qiang
  • Tamura, Yasushi
  • Roy, Madhuparna
  • Adachi, Yoshihiro
  • Iijima, Miho
  • Sesaki, Hiromi
subjects:
  • Dynamin-related GTPase
  • Mitochondrial fission
  • Mitochondrial fusion
  • Mitophagy
  • Apoptosis
  • Drp1
  • Mitofusin
  • Opa1
ispartof: Cellular and Molecular Life Sciences, 2014, Vol.71(19), pp.3767-3778
description: Mitochondria move, fuse and divide in cells. The dynamic behavior of mitochondria is central to the control of their structure and function. Three conserved mitochondrial dynamin-related GTPases (i.e., mitofusin, Opa1 and Drp1 in mammals and Fzo1, Mgm1 and Dnm1 in yeast) mediate mitochondrial fusion and division. In addition to dynamins, recent studies demonstrated that phospholipids in mitochondria also play key roles in mitochondrial dynamics by interacting with dynamin GTPases and by directly changing the biophysical properties of the mitochondrial membranes. Changes in phospholipid composition also promote mitophagy, which is a selective mitochondrial degradation process that is mechanistically coupled to mitochondrial division. In this review, we will discuss the biogenesis and function of mitochondrial phospholipids.
language: eng
source:
identifier: ISSN: 1420-682X ; E-ISSN: 1420-9071 ; DOI: 10.1007/s00018-014-1648-6
fulltext: fulltext
issn:
  • 1420-9071
  • 14209071
  • 1420-682X
  • 1420682X
url: Link


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titleBiosynthesis and roles of phospholipids in mitochondrial fusion, division and mitophagy
creatorZhang, Qiang ; Tamura, Yasushi ; Roy, Madhuparna ; Adachi, Yoshihiro ; Iijima, Miho ; Sesaki, Hiromi
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subjectDynamin-related GTPase ; Mitochondrial fission ; Mitochondrial fusion ; Mitophagy ; Apoptosis ; Drp1 ; Mitofusin ; Opa1
descriptionMitochondria move, fuse and divide in cells. The dynamic behavior of mitochondria is central to the control of their structure and function. Three conserved mitochondrial dynamin-related GTPases (i.e., mitofusin, Opa1 and Drp1 in mammals and Fzo1, Mgm1 and Dnm1 in yeast) mediate mitochondrial fusion and division. In addition to dynamins, recent studies demonstrated that phospholipids in mitochondria also play key roles in mitochondrial dynamics by interacting with dynamin GTPases and by directly changing the biophysical properties of the mitochondrial membranes. Changes in phospholipid composition also promote mitophagy, which is a selective mitochondrial degradation process that is mechanistically coupled to mitochondrial division. In this review, we will discuss the biogenesis and function of mitochondrial phospholipids.
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titleBiosynthesis and roles of phospholipids in mitochondrial fusion, division and mitophagy
descriptionMitochondria move, fuse and divide in cells. The dynamic behavior of mitochondria is central to the control of their structure and function. Three conserved mitochondrial dynamin-related GTPases (i.e., mitofusin, Opa1 and Drp1 in mammals and Fzo1, Mgm1 and Dnm1 in yeast) mediate mitochondrial fusion and division. In addition to dynamins, recent studies demonstrated that phospholipids in mitochondria also play key roles in mitochondrial dynamics by interacting with dynamin GTPases and by directly changing the biophysical properties of the mitochondrial membranes. Changes in phospholipid composition also promote mitophagy, which is a selective mitochondrial degradation process that is mechanistically coupled to mitochondrial division. In this review, we will discuss the biogenesis and function of mitochondrial phospholipids.
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titleBiosynthesis and roles of phospholipids in mitochondrial fusion, division and mitophagy
authorZhang, Qiang ; Tamura, Yasushi ; Roy, Madhuparna ; Adachi, Yoshihiro ; Iijima, Miho ; Sesaki, Hiromi
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abstractMitochondria move, fuse and divide in cells. The dynamic behavior of mitochondria is central to the control of their structure and function. Three conserved mitochondrial dynamin-related GTPases (i.e., mitofusin, Opa1 and Drp1 in mammals and Fzo1, Mgm1 and Dnm1 in yeast) mediate mitochondrial fusion and division. In addition to dynamins, recent studies demonstrated that phospholipids in mitochondria also play key roles in mitochondrial dynamics by interacting with dynamin GTPases and by directly changing the biophysical properties of the mitochondrial membranes. Changes in phospholipid composition also promote mitophagy, which is a selective mitochondrial degradation process that is mechanistically coupled to mitochondrial division. In this review, we will discuss the biogenesis and function of mitochondrial phospholipids.
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