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Plasma branched chain/aromatic amino acids, enriched Mediterranean diet and risk of type 2 diabetes: case-cohort study within the PREDIMED Trial

To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1007/s00125-018-4611-5 Byline: Miguel Ruiz-Canela (1,2,3), Marta Guasch-Ferre (3,4,5,6), Estefania Toledo (1,2,3), Clary B. Clish (7), Cristina Razquin (1,2,3), Liming Liang... Full description

Journal Title: Diabetologia 2018, Vol.61(7), pp.1560-1571
Main Author: Ruiz-Canela, Miguel
Other Authors: Guasch-Ferré, Marta , Toledo, Estefanía , Clish, Clary , Razquin, Cristina , Liang, Liming , Wang, Dong , Corella, Dolores , Estruch, Ramón , Hernáez, Álvaro , Yu, Edward , Gómez-Gracia, Enrique , Zheng, Yan , Arós, Fernando , Romaguera, Dora , Dennis, Courtney , Ros, Emilio , Lapetra, José , Serra-Majem, Lluis , Papandreou, Christopher , Portoles, Olga , Fitó, Montserrat , Salas-Salvadó, Jordi , Hu, Frank , Martínez-González, Miguel
Format: Electronic Article Electronic Article
Language: English
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ID: ISSN: 0012-186X ; E-ISSN: 1432-0428 ; DOI: 10.1007/s00125-018-4611-5
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recordid: springer_jour10.1007/s00125-018-4611-5
title: Plasma branched chain/aromatic amino acids, enriched Mediterranean diet and risk of type 2 diabetes: case-cohort study within the PREDIMED Trial
format: Article
creator:
  • Ruiz-Canela, Miguel
  • Guasch-Ferré, Marta
  • Toledo, Estefanía
  • Clish, Clary
  • Razquin, Cristina
  • Liang, Liming
  • Wang, Dong
  • Corella, Dolores
  • Estruch, Ramón
  • Hernáez, Álvaro
  • Yu, Edward
  • Gómez-Gracia, Enrique
  • Zheng, Yan
  • Arós, Fernando
  • Romaguera, Dora
  • Dennis, Courtney
  • Ros, Emilio
  • Lapetra, José
  • Serra-Majem, Lluis
  • Papandreou, Christopher
  • Portoles, Olga
  • Fitó, Montserrat
  • Salas-Salvadó, Jordi
  • Hu, Frank
  • Martínez-González, Miguel
subjects:
  • Aromatic amino acids
  • Branched-chain amino acids
  • Mediterranean diet
  • Type 2 diabetes
ispartof: Diabetologia, 2018, Vol.61(7), pp.1560-1571
description: To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1007/s00125-018-4611-5 Byline: Miguel Ruiz-Canela (1,2,3), Marta Guasch-Ferre (3,4,5,6), Estefania Toledo (1,2,3), Clary B. Clish (7), Cristina Razquin (1,2,3), Liming Liang (8), Dong D. Wang (4), Dolores Corella (3,9), Ramon Estruch (3,10), Alvaro Hernaez (3,11), Edward Yu (4,12), Enrique Gomez-Gracia (13), Yan Zheng (4), Fernando Aros (3,14), Dora Romaguera (3,15), Courtney Dennis (7), Emilio Ros (3,16), Jose Lapetra (3,17), Lluis Serra-Majem (3,18), Christopher Papandreou (3,5), Olga Portoles (3,9), Montserrat Fito (3,11), Jordi Salas-Salvado (3,5), Frank B. Hu (4,6,12), Miguel A. Martinez-Gonzalez (1,2,3,4) Keywords: Aromatic amino acids; Branched-chain amino acids; Mediterranean diet; Type 2 diabetes Abstract: Aims/hypothesis Branched-chain amino acids (BCAAs) and aromatic amino acids (AAAs) are associated with type 2 diabetes. However, repeated measurements of BCAA/AAA and their interactions with dietary interventions have not been evaluated. We investigated the associations between baseline and changes at 1 year in BCAA/AAA with type 2 diabetes in the context of a Mediterranean diet (MedDiet) trial. Methods We included 251 participants with incident type 2 diabetes and a random sample of 694 participants (641 participants without type 2 diabetes and 53 overlapping cases) in a case-cohort study nested within the PREvencion con DIeta MEDiterranea (PREDIMED) trial. Participants were randomised to a MedDiet+extra-virgin olive oil (n=273), a MedDiet+nuts (n=324) or a control diet (n=295). We used LC-MS/MS to measure plasma levels of amino acids. Type 2 diabetes was a pre-specified secondary outcome of the PREDIMED trial. Results Elevated plasma levels of individual BCAAs/AAAs were associated with higher type 2 diabetes risk after a median follow-up of 3.8 years: multivariable HR for the highest vs lowest quartile ranged from 1.32 for phenylalanine ([95% CI 0.90, 1.92], p for trend=0.015) to 3.29 for leucine ([95% CI 2.03, 5.34], p for trend
language: eng
source:
identifier: ISSN: 0012-186X ; E-ISSN: 1432-0428 ; DOI: 10.1007/s00125-018-4611-5
fulltext: fulltext_linktorsrc
issn:
  • 1432-0428
  • 14320428
  • 0012-186X
  • 0012186X
url: Link


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titlePlasma branched chain/aromatic amino acids, enriched Mediterranean diet and risk of type 2 diabetes: case-cohort study within the PREDIMED Trial
creatorRuiz-Canela, Miguel ; Guasch-Ferré, Marta ; Toledo, Estefanía ; Clish, Clary ; Razquin, Cristina ; Liang, Liming ; Wang, Dong ; Corella, Dolores ; Estruch, Ramón ; Hernáez, Álvaro ; Yu, Edward ; Gómez-Gracia, Enrique ; Zheng, Yan ; Arós, Fernando ; Romaguera, Dora ; Dennis, Courtney ; Ros, Emilio ; Lapetra, José ; Serra-Majem, Lluis ; Papandreou, Christopher ; Portoles, Olga ; Fitó, Montserrat ; Salas-Salvadó, Jordi ; Hu, Frank ; Martínez-González, Miguel
ispartofDiabetologia, 2018, Vol.61(7), pp.1560-1571
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subjectAromatic amino acids ; Branched-chain amino acids ; Mediterranean diet ; Type 2 diabetes
languageeng
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descriptionTo access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1007/s00125-018-4611-5 Byline: Miguel Ruiz-Canela (1,2,3), Marta Guasch-Ferre (3,4,5,6), Estefania Toledo (1,2,3), Clary B. Clish (7), Cristina Razquin (1,2,3), Liming Liang (8), Dong D. Wang (4), Dolores Corella (3,9), Ramon Estruch (3,10), Alvaro Hernaez (3,11), Edward Yu (4,12), Enrique Gomez-Gracia (13), Yan Zheng (4), Fernando Aros (3,14), Dora Romaguera (3,15), Courtney Dennis (7), Emilio Ros (3,16), Jose Lapetra (3,17), Lluis Serra-Majem (3,18), Christopher Papandreou (3,5), Olga Portoles (3,9), Montserrat Fito (3,11), Jordi Salas-Salvado (3,5), Frank B. Hu (4,6,12), Miguel A. Martinez-Gonzalez (1,2,3,4) Keywords: Aromatic amino acids; Branched-chain amino acids; Mediterranean diet; Type 2 diabetes Abstract: Aims/hypothesis Branched-chain amino acids (BCAAs) and aromatic amino acids (AAAs) are associated with type 2 diabetes. However, repeated measurements of BCAA/AAA and their interactions with dietary interventions have not been evaluated. We investigated the associations between baseline and changes at 1 year in BCAA/AAA with type 2 diabetes in the context of a Mediterranean diet (MedDiet) trial. Methods We included 251 participants with incident type 2 diabetes and a random sample of 694 participants (641 participants without type 2 diabetes and 53 overlapping cases) in a case-cohort study nested within the PREvencion con DIeta MEDiterranea (PREDIMED) trial. Participants were randomised to a MedDiet+extra-virgin olive oil (n=273), a MedDiet+nuts (n=324) or a control diet (n=295). We used LC-MS/MS to measure plasma levels of amino acids. Type 2 diabetes was a pre-specified secondary outcome of the PREDIMED trial. Results Elevated plasma levels of individual BCAAs/AAAs were associated with higher type 2 diabetes risk after a median follow-up of 3.8 years: multivariable HR for the highest vs lowest quartile ranged from 1.32 for phenylalanine ([95% CI 0.90, 1.92], p for trend=0.015) to 3.29 for leucine ([95% CI 2.03, 5.34], p for trend<0.001). Increases in BCAA score at 1 year were associated with higher type 2 diabetes risk in the control group with HR per SD=1.61 (95% CI 1.02, 2.54), but not in the MedDiet groups (p for interaction <0.001). The MedDiet+extra-virgin olive oil significantly reduced BCAA levels after 1 year of intervention (p= 0.005 vs the control group). Conclusions/interpretation Our results support that higher baseline BCAAs and their increases at 1 year were associated with higher type 2 diabetes risk. A Mediterranean diet rich in extra-virgin olive oil significantly reduced the levels of BCAA and attenuated the positive association between plasma BCAA levels and type 2 diabetes incidence. Clinical trial number: SRCTN35739639 (www.controlled-trials.com) Author Affiliation: (1) 0000000419370271, grid.5924.a, Department of Preventive Medicine and Public Health, Facultad de Medicina, Universidad de Navarra, Irunlarrea 1, 31008, Pamplona, Spain (2) IdiSNA, Navarra Institute for Health Research, Pamplona, Spain (3) 0000 0000 9314 1427, grid.413448.e, CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain (4) 000000041936754X, grid.38142.3c, Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA (5) 0000 0001 2284 9230, grid.410367.7, Human Nutrition Unit, Faculty of Medicine and Health Sciences, Pere Virgili Health Research Institute, Rovira i Virgili University, Reus, Spain (6) 0000 0004 0378 8294, grid.62560.37, Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA (7) grid.66859.34, Broad Institute of MIT and Harvard University, Cambridge, MA, USA (8) 000000041936754X, grid.38142.3c, Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA (9) 0000 0001 2173 938X, grid.5338.d, Department of Preventive Medicine, University of Valencia, Valencia, Spain (10) Department of Internal Medicine, Biomedical Research Institute August Pi Sunyer (IDI- BAPS), Hospital Clinic, University of Barcelona, Barcelona, Spain (11) 0000 0004 1767 8811, grid.411142.3, Cardiovascular and Nutrition Research Group (Regicor Study Group), Hospital del Mar Research Institute (IMIM), Barcelona, Spain (12) 000000041936754X, grid.38142.3c, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA (13) 0000 0001 2298 7828, grid.10215.37, Department of Preventive Medicine, University of Malaga, Malaga, Spain (14) 0000000121671098, grid.11480.3c, Department of Cardiology, University Hospital, University of the Basque Country UPV/EHU, Vitoria-Gasteiz, Spain (15) 0000 0004 1796 5984, grid.411164.7, Health Research Institute of the Balearic Islands (IdISBa), University Hospital Son Espases, Mallorca, Spain (16) 0000 0004 1937 0247, grid.5841.8, Lipid Clinic, Department of Endocrinology and Nutrition Biomedical Research Institute August Pi Sunyer (IDIBAPS), Hospital Clinic, University of Barcelona, Barcelona, Spain (17) Department of Family Medicine, Research Unit, Primary Care Division of Sevilla, Sevilla, Spain (18) Research Institute of Biomedical and Health Sciences and Medical School University of Las Palmas de Gran Canarias, Las Palmas de Gran Canaria, Spain Article History: Registration Date: 28/03/2018 Received Date: 17/10/2017 Accepted Date: 12/03/2018 Online Date: 16/04/2018 Article note: Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00125-018-4611-5) contains peer-reviewed but unedited supplementary material, which is available to authorised users.
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