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Is it time for immunopsychiatry in psychotic disorders?

Issue Title: Immune Influences on Brain & Behaviour: from Psychoneuroimmunology to Immunopsychiatry Introduction: Immune dysregulation is suggested to play an important aetiological role in schizophrenia (SZ) and bipolar disorder (BD) potentially driving neurodevelopmental pathways. Immune dysfuncti... Full description

Journal Title: Psychopharmacology 2016, Vol.233(9), pp.1651-1660
Main Author: Leboyer, Marion
Other Authors: Oliveira, José , Tamouza, Ryad , Groc, Laurent
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0033-3158 ; E-ISSN: 1432-2072 ; DOI: 10.1007/s00213-016-4266-1
Link: http://dx.doi.org/10.1007/s00213-016-4266-1
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recordid: springer_jour10.1007/s00213-016-4266-1
title: Is it time for immunopsychiatry in psychotic disorders?
format: Article
creator:
  • Leboyer, Marion
  • Oliveira, José
  • Tamouza, Ryad
  • Groc, Laurent
subjects:
  • Schizophrenia
  • Bipolar disorder
  • Immunopsychiatry
  • Immunogenetics
  • Gene-environment interactions
  • NMDA receptor
  • HERV-W
ispartof: Psychopharmacology, 2016, Vol.233(9), pp.1651-1660
description: Issue Title: Immune Influences on Brain & Behaviour: from Psychoneuroimmunology to Immunopsychiatry Introduction: Immune dysregulation is suggested to play an important aetiological role in schizophrenia (SZ) and bipolar disorder (BD) potentially driving neurodevelopmental pathways. Immune dysfunction may precede the onset of psychiatric disorders and parallel the development of multiaxial comorbidity, including suicidal behaviour and metabolic and autoimmune disorders. Depicting the source of the chronic low-grade inflammatory component in SZ and BD is thus a research priority. Strong environmental insults early in life, such as infections, acting on a background of genetic vulnerability, may induce potent and enduring inflammatory responses setting a state of liability to second-hit environmental encounters, namely childhood trauma, drug abuse or additional infectious exposures. The immunogenetic background of susceptibility, suggested to be not only lying within the HLA locus but also implicating inherited deficits of the innate immune system, may amplify the harmful biological effects of infections/psychosocial stress leading to the manifestation of a broad range of psychiatric symptoms. Objectives: The present review aims to discuss the following: (i) biological arguments in favour of a chronic low-grade inflammation in SZ and BD and its potential origin in the interaction between the immunogenetic background and environmental infectious insults, and (ii) the consequences of this inflammatory dysfunction by focusing on N-methyl-d-aspartate (NMDA) receptor antibodies and activation of the family of human endogenous retroviruses (HERVs). Conclusions: Specific therapeutic approaches targeting immune pathways may lead the way to novel personalized medical interventions, improvement of quality of life and average life expectancy of psychiatric patients, if not even prevent mood episodes and psychotic symptoms.
language: eng
source:
identifier: ISSN: 0033-3158 ; E-ISSN: 1432-2072 ; DOI: 10.1007/s00213-016-4266-1
fulltext: fulltext
issn:
  • 1432-2072
  • 14322072
  • 0033-3158
  • 00333158
url: Link


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titleIs it time for immunopsychiatry in psychotic disorders?
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descriptionIssue Title: Immune Influences on Brain & Behaviour: from Psychoneuroimmunology to Immunopsychiatry Introduction: Immune dysregulation is suggested to play an important aetiological role in schizophrenia (SZ) and bipolar disorder (BD) potentially driving neurodevelopmental pathways. Immune dysfunction may precede the onset of psychiatric disorders and parallel the development of multiaxial comorbidity, including suicidal behaviour and metabolic and autoimmune disorders. Depicting the source of the chronic low-grade inflammatory component in SZ and BD is thus a research priority. Strong environmental insults early in life, such as infections, acting on a background of genetic vulnerability, may induce potent and enduring inflammatory responses setting a state of liability to second-hit environmental encounters, namely childhood trauma, drug abuse or additional infectious exposures. The immunogenetic background of susceptibility, suggested to be not only lying within the HLA locus but also implicating inherited deficits of the innate immune system, may amplify the harmful biological effects of infections/psychosocial stress leading to the manifestation of a broad range of psychiatric symptoms. Objectives: The present review aims to discuss the following: (i) biological arguments in favour of a chronic low-grade inflammation in SZ and BD and its potential origin in the interaction between the immunogenetic background and environmental infectious insults, and (ii) the consequences of this inflammatory dysfunction by focusing on N-methyl-d-aspartate (NMDA) receptor antibodies and activation of the family of human endogenous retroviruses (HERVs). Conclusions: Specific therapeutic approaches targeting immune pathways may lead the way to novel personalized medical interventions, improvement of quality of life and average life expectancy of psychiatric patients, if not even prevent mood episodes and psychotic symptoms.
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