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Microchip-based cellular biochemical systems for practical applications and fundamental research: from microfluidics to nanofluidics

By combining cell technology and microchip technology, innovative cellular biochemical tools can be created from the microscale to the nanoscale for both practical applications and fundamental research. On the microscale level, novel practical applications taking advantage of the unique capabilities... Full description

Journal Title: Analytical and Bioanalytical Chemistry 2012, Vol.402(1), pp.99-107
Main Author: Xu, Yan
Other Authors: Jang, Kihoon , Yamashita, Tadahiro , Tanaka, Yo , Mawatari, Kazuma , Kitamori, Takehiko
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1618-2642 ; E-ISSN: 1618-2650 ; DOI: 10.1007/s00216-011-5296-5
Link: http://dx.doi.org/10.1007/s00216-011-5296-5
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recordid: springer_jour10.1007/s00216-011-5296-5
title: Microchip-based cellular biochemical systems for practical applications and fundamental research: from microfluidics to nanofluidics
format: Article
creator:
  • Xu, Yan
  • Jang, Kihoon
  • Yamashita, Tadahiro
  • Tanaka, Yo
  • Mawatari, Kazuma
  • Kitamori, Takehiko
subjects:
  • Extended-nano space
  • Tissue engineering
  • Cell-based assay
  • DNA detection
  • Single cell
  • Single molecule
ispartof: Analytical and Bioanalytical Chemistry, 2012, Vol.402(1), pp.99-107
description: By combining cell technology and microchip technology, innovative cellular biochemical tools can be created from the microscale to the nanoscale for both practical applications and fundamental research. On the microscale level, novel practical applications taking advantage of the unique capabilities of microfluidics have been accelerated in clinical diagnosis, food safety, environmental monitoring, and drug discovery. On the other hand, one important trend of this field is further downscaling of feature size to the 10 1 –10 3  nm scale, which we call extended-nano space. Extended-nano space technology is leading to the creation of innovative nanofluidic cellular and biochemical tools for analysis of single cells at the single-molecule level. As a pioneering group in this field, we focus not only on the development of practical applications of cellular microchip devices but also on fundamental research to initiate new possibilities in the field. In this paper, we review our recent progress on tissue reconstruction, routine cell-based assays on microchip systems, and preliminary fundamental method for single-cell analysis at the single-molecule level with integration of the burgeoning technologies of extended-nano space. Figure By combination of cell technology and microchip technology, innovative cellular biochemical tools can be created from the microscale to the nanoscale, for both practical applications and fundamental research. The image demonstrates a concept of analysis of a single cell at the singlemolecule level on a microchip with integration of extended-nano (101–103 nm) space.
language: eng
source:
identifier: ISSN: 1618-2642 ; E-ISSN: 1618-2650 ; DOI: 10.1007/s00216-011-5296-5
fulltext: fulltext
issn:
  • 1618-2650
  • 16182650
  • 1618-2642
  • 16182642
url: Link


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titleMicrochip-based cellular biochemical systems for practical applications and fundamental research: from microfluidics to nanofluidics
creatorXu, Yan ; Jang, Kihoon ; Yamashita, Tadahiro ; Tanaka, Yo ; Mawatari, Kazuma ; Kitamori, Takehiko
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subjectExtended-nano space ; Tissue engineering ; Cell-based assay ; DNA detection ; Single cell ; Single molecule
descriptionBy combining cell technology and microchip technology, innovative cellular biochemical tools can be created from the microscale to the nanoscale for both practical applications and fundamental research. On the microscale level, novel practical applications taking advantage of the unique capabilities of microfluidics have been accelerated in clinical diagnosis, food safety, environmental monitoring, and drug discovery. On the other hand, one important trend of this field is further downscaling of feature size to the 10 1 –10 3  nm scale, which we call extended-nano space. Extended-nano space technology is leading to the creation of innovative nanofluidic cellular and biochemical tools for analysis of single cells at the single-molecule level. As a pioneering group in this field, we focus not only on the development of practical applications of cellular microchip devices but also on fundamental research to initiate new possibilities in the field. In this paper, we review our recent progress on tissue reconstruction, routine cell-based assays on microchip systems, and preliminary fundamental method for single-cell analysis at the single-molecule level with integration of the burgeoning technologies of extended-nano space. Figure By combination of cell technology and microchip technology, innovative cellular biochemical tools can be created from the microscale to the nanoscale, for both practical applications and fundamental research. The image demonstrates a concept of analysis of a single cell at the singlemolecule level on a microchip with integration of extended-nano (101–103 nm) space.
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abstractBy combining cell technology and microchip technology, innovative cellular biochemical tools can be created from the microscale to the nanoscale for both practical applications and fundamental research. On the microscale level, novel practical applications taking advantage of the unique capabilities of microfluidics have been accelerated in clinical diagnosis, food safety, environmental monitoring, and drug discovery. On the other hand, one important trend of this field is further downscaling of feature size to the 10 1 –10 3  nm scale, which we call extended-nano space. Extended-nano space technology is leading to the creation of innovative nanofluidic cellular and biochemical tools for analysis of single cells at the single-molecule level. As a pioneering group in this field, we focus not only on the development of practical applications of cellular microchip devices but also on fundamental research to initiate new possibilities in the field. In this paper, we review our recent progress on tissue reconstruction, routine cell-based assays on microchip systems, and preliminary fundamental method for single-cell analysis at the single-molecule level with integration of the burgeoning technologies of extended-nano space. Figure By combination of cell technology and microchip technology, innovative cellular biochemical tools can be created from the microscale to the nanoscale, for both practical applications and fundamental research. The image demonstrates a concept of analysis of a single cell at the singlemolecule level on a microchip with integration of extended-nano (101–103 nm) space.
copBerlin/Heidelberg
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doi10.1007/s00216-011-5296-5
pages99-107
date2012-01