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A snapshot of the Mamu - B genes and their allelic repertoire in rhesus macaques of Chinese origin

The major histocompatibility complex class I gene repertoire was investigated in a large panel of rhesus macaques of Chinese origin. As observed in Indian animals, subjects of Chinese derivation display Mamu - B gene copy number variation, and the sum of expressed genes varies among haplotypes. In a... Full description

Journal Title: Immunogenetics 2008, Vol.60(9), pp.507-514
Main Author: Otting, Nel
Other Authors: Heijmans, Corrine , Wiel, Marit , Groot, Natasja , Doxiadis, Gaby , Bontrop, Ronald
Format: Electronic Article Electronic Article
Language: English
Subjects:
MHC
ID: ISSN: 0093-7711 ; E-ISSN: 1432-1211 ; DOI: 10.1007/s00251-008-0311-5
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recordid: springer_jour10.1007/s00251-008-0311-5
title: A snapshot of the Mamu - B genes and their allelic repertoire in rhesus macaques of Chinese origin
format: Article
creator:
  • Otting, Nel
  • Heijmans, Corrine
  • Wiel, Marit
  • Groot, Natasja
  • Doxiadis, Gaby
  • Bontrop, Ronald
subjects:
  • Nonhuman primates
  • MHC
  • Macaques
  • Evolution
ispartof: Immunogenetics, 2008, Vol.60(9), pp.507-514
description: The major histocompatibility complex class I gene repertoire was investigated in a large panel of rhesus macaques of Chinese origin. As observed in Indian animals, subjects of Chinese derivation display Mamu - B gene copy number variation, and the sum of expressed genes varies among haplotypes. In addition, these genes display differential transcription levels. The majority of the Mamu - B alleles discovered during this investigation appear to be unique for the population studied. Only one particular Mamu - B haplotype is shared between Indian and Chinese animals, and it must have been present in the progenitor stock. Hence, the data highlight the fact that most allelic polymorphism, and most of the Mamu - B haplotypes themselves, are of relatively recent origin and were most likely generated after the separation of the Indian and Chinese rhesus macaque populations.
language: eng
source:
identifier: ISSN: 0093-7711 ; E-ISSN: 1432-1211 ; DOI: 10.1007/s00251-008-0311-5
fulltext: fulltext_linktorsrc
issn:
  • 1432-1211
  • 14321211
  • 0093-7711
  • 00937711
url: Link


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titleA snapshot of the Mamu - B genes and their allelic repertoire in rhesus macaques of Chinese origin
creatorOtting, Nel ; Heijmans, Corrine ; Wiel, Marit ; Groot, Natasja ; Doxiadis, Gaby ; Bontrop, Ronald
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descriptionThe major histocompatibility complex class I gene repertoire was investigated in a large panel of rhesus macaques of Chinese origin. As observed in Indian animals, subjects of Chinese derivation display Mamu - B gene copy number variation, and the sum of expressed genes varies among haplotypes. In addition, these genes display differential transcription levels. The majority of the Mamu - B alleles discovered during this investigation appear to be unique for the population studied. Only one particular Mamu - B haplotype is shared between Indian and Chinese animals, and it must have been present in the progenitor stock. Hence, the data highlight the fact that most allelic polymorphism, and most of the Mamu - B haplotypes themselves, are of relatively recent origin and were most likely generated after the separation of the Indian and Chinese rhesus macaque populations.
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titleA snapshot of the Mamu - B genes and their allelic repertoire in rhesus macaques of Chinese origin
descriptionThe major histocompatibility complex class I gene repertoire was investigated in a large panel of rhesus macaques of Chinese origin. As observed in Indian animals, subjects of Chinese derivation display Mamu - B gene copy number variation, and the sum of expressed genes varies among haplotypes. In addition, these genes display differential transcription levels. The majority of the Mamu - B alleles discovered during this investigation appear to be unique for the population studied. Only one particular Mamu - B haplotype is shared between Indian and Chinese animals, and it must have been present in the progenitor stock. Hence, the data highlight the fact that most allelic polymorphism, and most of the Mamu - B haplotypes themselves, are of relatively recent origin and were most likely generated after the separation of the Indian and Chinese rhesus macaque populations.
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titleA snapshot of the Mamu - B genes and their allelic repertoire in rhesus macaques of Chinese origin
authorOtting, Nel ; Heijmans, Corrine ; Wiel, Marit ; Groot, Natasja ; Doxiadis, Gaby ; Bontrop, Ronald
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abstractThe major histocompatibility complex class I gene repertoire was investigated in a large panel of rhesus macaques of Chinese origin. As observed in Indian animals, subjects of Chinese derivation display Mamu - B gene copy number variation, and the sum of expressed genes varies among haplotypes. In addition, these genes display differential transcription levels. The majority of the Mamu - B alleles discovered during this investigation appear to be unique for the population studied. Only one particular Mamu - B haplotype is shared between Indian and Chinese animals, and it must have been present in the progenitor stock. Hence, the data highlight the fact that most allelic polymorphism, and most of the Mamu - B haplotypes themselves, are of relatively recent origin and were most likely generated after the separation of the Indian and Chinese rhesus macaque populations.
copBerlin/Heidelberg
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doi10.1007/s00251-008-0311-5
pages507-514
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